Thermoanalytical methods applied to medicine

Abstract

Thermoanalytical methods have found increasing application in medicine due to the improved sensitivity and usability of the available instrumentation. Studies have identified important findings applied to medicine, including information on the thermal properties of the skin and the effect of insertion into body cavities of implants and prosthetics. These studies have explored the thermal stability of various materials to provide insight into drug penetration in order to design drug delivery systems, which are not only safe but capable of delivering improved and predictable therapeutic outcomes for patients. Differential scanning calorimetry (DSC) has also been applied to the study of disease states such as diabetes, where changes in the collagen structure of the skin, which may lead to long-term complications in these patients, can be detected. Although these results may at this stage not have significant clinical implications, they do provide medical researchers with a starting point for future investigations. The application of these techniques has been further extended to examinations of body systems and other disease states. The key for the future will be the ability of these techniques not only to provide information on alterations in these biological systems, but also to determine whether these alterations are clinically relevant.

In Melting Points We Trust: A Review on the Misguiding Characterization of Multicomponent Reactions Adducts and Intermediates

“…This property is crucial for mps measurements since different solid states phases and transitions associated with those phases are commonly observed in polymorphic crystals [ 29 , 30 ]. Thermoanalytical methods are therefore widely applied to investigate polymorphism [ 31 , 32 ]. Since mps measurements are typically affected by polymorphism [ 28 ], additional well-conducted XRD analysis is the least required for the proper characterization of polymorphs.…”

Thermal Analysis

“…Glass and Brown have provided an overview of the applications of thermal analysis methods in medicine. Clinical diagnostic applications of DSC has been reviewed by Garbett et al , who indicate that DSC curves of blood plasma are specific to a disease as well as to its progress.…”

“…Glass and Brown (246) have provided an overview of the applications of thermal analysis methods in medicine. Clinical diagnostic applications of DSC has been reviewed by Garbett et al.…”