Thermodynamic computational calculations for preparation 5-fluorouracil magnetic moleculary imprinted polymers and their application in controlled drug release

Talavat, Laleh; Güner, Ali̇

doi:10.1016/j.inoche.2019.02.009

Cited by 11 publications

(15 citation statements)

References 28 publications

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“…However, the employment of MMIPs as carriers of anticancer agents is emerging. Only a few publications reported the development of MMIPs with the aim of smart delivery of anticancer drugs local to the tumor [ 3 , 50 , 54 , 61 , 65 , 68 , 77 , 78 , 79 , 80 , 81 ] that shed light on the development of a novel generation of multifunctional hybrid DDSs and future perspectives in this field.…”

Section: State Of the Artmentioning

confidence: 99%

“…5-FU, DOX and EPI with a broad antineoplastic spectrum are used to treat many different types of cancer as colon or rectum, breast, liver, bladder and brain [ 50 , 61 , 79 , 80 ]. The main drawbacks of direct chemotherapy with these agents can be listed as severe depression of hematopoiesis (anemia, leucopenia, thrombopenia), infection and cardiotoxicity regarding EPI [ 50 ], 5-FU resistance and rapid clearance from the body [ 6 ] and DOX cumulative cardiotoxicity and nephrotoxicity [ 82 ].…”

Section: State Of the Artmentioning

confidence: 99%

“…The combination of a magnetic core covered by a thin MIP shell leads to the generation of smart hybrid structures, namely magnetic MIPs (MMIPs) that provides the possibility of high drug loading and low off-target drug release followed by remote guidance, rapid distribution and local accumulation of the obtained MMIPs by using an external magnetic field [ 59 ]. Due to the good biocompatibility and chemical, thermal and mechanical stability, high sorption capacity, high selectivity, reusability, low cost and facile preparation method of the available magnetic materials, especially magnetic NPs (MNPs), the design of MMIPs as DDSs is recently become favorable [ 60 , 61 ]. Due to the high surface-to-volume-ratio of MNP, compared to MIPs, imprinting position of the polymer at the surface is increased leading to MMIPs with more accessible imprinted positions, rapid mass transfer and hence, fewer permeability issues, as well as strong anti-interference ability [ 62 ].…”

Section: Introductionmentioning

confidence: 99%

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Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Sanadgol

Wackerlig

2020

Pharmaceutics

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Cancer therapy is still a huge challenge, as especially chemotherapy shows several drawbacks like low specificity to tumor cells, rapid elimination of drugs, high toxicity and lack of aqueous solubility. The combination of molecular imprinting technology with magnetic nanoparticles provides a new class of smart hybrids, i.e., magnetic molecularly imprinted polymers (MMIPs) to overcome limitations in current cancer therapy. The application of these complexes is gaining more interest in therapy, due to their favorable properties, namely, the ability to be guided and to generate slight hyperthermia with an appropriate external magnetic field, alongside the high selectivity and loading capacity of imprinted polymers toward a template molecule. In cancer therapy, using the MMIPs as smart-drug-delivery robots can be a promising alternative to conventional direct administered chemotherapy, aiming to enhance drug accumulation/penetration into the tumors while fewer side effects on the other organs. Overview: In this review, we state the necessity of further studies to translate the anticancer drug-delivery systems into clinical applications with high efficiency. This work relates to the latest state of MMIPs as smart-drug-delivery systems aiming to be used in chemotherapy. The application of computational modeling toward selecting the optimum imprinting interaction partners is stated. The preparation methods employed in these works are summarized and their attainment in drug-loading capacity, release behavior and cytotoxicity toward cancer cells in the manner of in vitro and in vivo studies are stated. As an essential issue toward the development of a body-friendly system, the biocompatibility and toxicity of the developed drug-delivery systems are discussed. We conclude with the promising perspectives in this emerging field. Areas covered: Last ten years of publications (till June 2020) in magnetic molecularly imprinted polymeric nanoparticles for application as smart-drug-delivery systems in chemotherapy.

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Section: State Of the Artmentioning

confidence: 99%

Section: State Of the Artmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Sanadgol

Wackerlig

2020

Pharmaceutics

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“…To simplify the empirical design space in paring the appropriate functional monomer to the drug template, thermodynamic computational calculations may be employed for the prescreening of functional monomer candidates likely to form stable complexes with the drug molecule in the pre-polymerization step. As such, 4-vinylpyridine (4-VPy) and acrylic acid (AA) were selected as optimal functional monomers for the preparation of MIPs for the controlled release of 5-FU [71]. The polymerization was performed in a mixture of ACN/methanol 80:20 (v/v), using EDMA as crosslinker.…”

Section: Non-covalent Imprintingmentioning

confidence: 99%

“…Therefore, in order to exploit this approach in designing pH-responsive MIPs, polymers bearing basic functionalities on their structure should be employed, which will become protonated in the acidic pH of tumor environment, however currently reported results show modest to moderate success. In one such attempt, a pH sensitive MIP-based DDS was recently developed for 5-FU delivery [71] and was prepared with a basic monomer, 4-VPy. At both pH 5.8 and 7.4, respectively, the release profiles showed an initial burst (of five days) and then a slow release (up to 30 days) of the imprinted drug.…”

Section: Stimuli Responsive Imprinted Dds For Cancer Treatmentmentioning

confidence: 99%

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

2019

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Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics' release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.Polymers 2019, 11, 2085 2 of 33 normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.Polymers 2019, 11, x FOR PEER REVIEW 2 of 34 of both normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.

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Stimuli‐Responsive Molecularly Imprinted Polymers: Mechanism and Applications

Li,

Deng,

et al. 2024

J of Separation Science

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Molecularly imprinted polymers (MIPs) are very suitable for extraction, drug delivery systems, and sensors due to their good selective adsorption ability, but the difficulty of eluting templates during synthesis and the limitation of application scenarios put higher demands on MIPs. Stimuli‐responsive MIPs (SR‐MIPs) can actively respond to changes in external conditions to realize various functions, which provides new ideas for the further development of MIPs. This paper reviews the multiple response modes of MIPs, including the common temperature, pH, photo, magnetic, redox‐responsive and rare gas, biomolecule, ion, and solvent‐responsive MIPs, and explains the mechanism, composition, and applications of such SR‐MIPs. These SR‐MIPs and the resulting dual/multiple‐responsive MIPs have good selectivity, and controllability, and are very promising for isolation and extraction, targeted drug delivery, and electro‐sensor.

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Thermodynamic computational calculations for preparation 5-fluorouracil magnetic moleculary imprinted polymers and their application in controlled drug release

Cited by 11 publications

References 28 publications

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

Stimuli‐Responsive Molecularly Imprinted Polymers: Mechanism and Applications

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