Thermodynamic study on dynamic water and organic vapor sorption on amorphous valnemulin hydrochloride

Ouyang, Jinbo; Wang, Jingkang; Wang, Yongli; Yin, Qiuxiang; Hao, Hongxun

doi:10.1007/s11705-015-1460-3

Cited by 17 publications

(9 citation statements)

References 25 publications

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“…DVS is a technique capable of measuring mass changes in materials in an extremely controlled environment with excellent accuracy. It has been widely used in investigating the sorption and desorption properties of materials to explore, hydrate, and solvate formations, determining the amorphous contents in pharmaceutical materials, etc . Briefly, RH was raised in 10 steps (that is 10% ramp/step) from 0 to 95% RH.…”

Section: Methodsmentioning

confidence: 99%

“…It has been widely used in investigating the sorption and desorption properties of materials to explore, hydrate, and solvate formations, determining the amorphous contents in pharmaceutical materials, etc. 25,26 Briefly, RH was raised in 10 steps (that is 10% ramp/step) from 0 to 95% RH. The equilibration parameter set was 0.0005%/min for the rate of mass change per unit time (dm/dt).…”

Section: Water Sorptionmentioning

confidence: 99%

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Amelioration in physicochemical properties and single cell performance of sulfonated poly(ether ether ketone) block copolymer composite membrane using sulfonated carbon nanotubes for intermediate humidity fuel cells

2019

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Summary A composite membrane composed of a sulfonated diblock copolymer (SDBC) based on poly(ether ether ketone) blocks copolymerized with partially fluorinated poly(arylene ether sulfone) and sulfonated carbon nanotubes (SCNTs) was fabricated by simple solution casting. Addition of the SCNT filler enhanced the water absorption and proton conductivity of membranes because of the increased per‐cluster volume of sulfonic acid groups, at the same time reinforced the membranes' thermal and mechanical properties. The SDBC/SCNT‐1.5 membrane exhibited the most improved physicochemical properties among all materials. It obtained a proton conductivity of 10.1 mS/cm at 120°C under 20% relative humidity (RH) which was 2.6 times more improved than the pristine membrane (3.9 mS/cm). Moreover, the single cell performance of the SDBC/SCNT‐1.5 membrane at 60°C and 60% RH at ambient pressure exhibited a peak power density of 171 mW/cm2 at a load current density of 378 mA/cm2, while the pristine membrane exhibited 119 mW/cm2 at a load current density of 294 mA/cm2. Overall, the composite membrane exhibited very promising characteristics to be used as polymer electrolyte membrane in fuel cells operated at intermediate RH.

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Section: Methodsmentioning

confidence: 99%

Section: Water Sorptionmentioning

confidence: 99%

Amelioration in physicochemical properties and single cell performance of sulfonated poly(ether ether ketone) block copolymer composite membrane using sulfonated carbon nanotubes for intermediate humidity fuel cells

2019

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“…The noticeable increase in EMC values above 50% RH, signifies a change in mechanism of water sorption. Several mechanisms have been proposed for the interactions between water vapour and adsorbent molecules which mainly include: surface adsorption, bulk adsorption, hydration, gelation, and deliquescence (Ouyang et al, 2015). It has been suggested that, at low relative humidity values, water vapour sorption is an entropy-controlled process which is associated with the number of available sorption sites, as well as randomness of the motion of water molecules.…”

Section: Characteristics Of Moisture Sorptionmentioning

confidence: 99%

Evolution of surface micro-structure and moisture sorption characteristics of spray-dried detergent powders

Farshchi

Hassanpour

Ettelaie

et al. 2019

Journal of Colloid and Interface Science

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“…Many pharmaceuticals fail clinical trials, mostly due to pure physicochemical properties, including poor dissolution rate, low crystallinity, and strong hygroscopicity [1,2]. Thus, the discovery of methods that can improve the dissolution rate and stability of active pharmaceutical ingredient (API) is an important challenge in the pharmaceutical industry.…”

Section: Introductionmentioning

confidence: 99%

Effect of Solid Forms on Physicochemical Properties of Valnemulin

et al. 2019

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To improve the physicochemical properties of valnemulin (VLM), different solid forms formed by VLM and organic acids, including tartaric acid (TAR), fumaric acid (FUM), and oxalic acid (OXA), were successfully prepared and characterized by using differential scanning calorimetry (DSC), scanning electron microscope (SEM), X-ray powder diffraction (XRPD), and Fourier-transform infrared spectroscopy (FT-IR). The excess enthalpy Hex between VLM and other organic acids was calculated by COSMOthermX software and was used to evaluate the probability of forming multi-component solids between VLM and organic acids. By thermal analysis, it was confirmed that multi-component solid forms of VLM were thermodynamically more stable than VLM itself. Through dynamic vapor sorption (DVS) experiments, it was found that three multi-component solid forms of VLM had lower hygroscopicity than VLM itself. Furthermore, the intrinsic dissolution rate of VLM and its multi-component forms was determined in one kind of acidic aqueous medium by using UV-vis spectrometry. It was found that the three multi-component solid forms of VLM dissolved faster than VLM itself.

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Thermodynamic study on dynamic water and organic vapor sorption on amorphous valnemulin hydrochloride

Cited by 17 publications

References 25 publications

Amelioration in physicochemical properties and single cell performance of sulfonated poly(ether ether ketone) block copolymer composite membrane using sulfonated carbon nanotubes for intermediate humidity fuel cells

Amelioration in physicochemical properties and single cell performance of sulfonated poly(ether ether ketone) block copolymer composite membrane using sulfonated carbon nanotubes for intermediate humidity fuel cells

Evolution of surface micro-structure and moisture sorption characteristics of spray-dried detergent powders

Effect of Solid Forms on Physicochemical Properties of Valnemulin

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