Thermogravimetric and calorimetric studies performed on memantine hydrochloride to determine its thermal behaviour and possible drug–excipient interactions

Formulation and Characterization of Alginate-Based Membranes for the Potential Transdermal Delivery of Methotrexate

“…Comparing the HF and TGA curves shown in Figure 9 it can be said that the thermal analysis performed in the case of ATG-MTX membrane contains the decomposition processes of the membrane and the active substance, the exothermic process of the active substance around 350 °C is also present in the membrane, is more extensive containing the process of membrane decomposition which leads us to the idea that the membrane contains the active principle intact [ 20 ]. Although in the study of the binary mixture between T w and MTX we noticed that MTX interacts with T w , in the case of alginate-based membrane and T w the conclusion is different, namely the addition of T w in the membrane blocks the interaction between MTX and T w because a copolymer is obtained between alginate and T w that does not interact with the active substance [ 21 , 22 ].…”

“…In the case of the MTX + PVP mixture, the bands characteristic of the active substance is visible next to the band from 1660 cm −1 attributed to the stretching vibration of C=O, as well as the peak at 2950 cm −1 attributed to the asymmetric stretching of the CH 2 vibration in the PVP skeleton chain. From the point of view of the FTIR study, we can say that there are no interactions between MTX and PVP in the binary mixture ( Figure 10 ) [ 14 , 21 , 22 ].…”

Dental Biopolymer Composites with Antibiotics, Bisphosphonate and Hydroxyapatite for Possible Use in Bone Tissue Regeneration

“…Several processes can be observed on the HF curve, namely, an exothermic process with a maximum at 230 °C with a loss of 69.26% of the sample mass, followed by an endothermic process with a maximum at 260 °C with a loss of 21.58%. Te literature suggests that ampicillin monohydrate exhibits a melting process that begins with the decomposition of the sample [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54].…”

“…During the obtaining new bone-grafting materials, it is very important to know the physicochemical properties of drugs and the individual components. Te studies presented in the literature prove that thermal analysis techniques are methods used for the physicochemical characterization of various materials used in pharmaceutical and other felds [37][38][39][40][41][42][43][44][45][46][47]. In the present paper, by combining the complementary physicochemical techniques, TG/DTG/HF, FTIR-UATR, UV-Vis ultraviolet-visible, and SEM-EDX, it is determined which is the best bone-grafting material that can be used to release the analyzed active ingredients individually and in the form of a mixture.…”

Preliminary Study for the Preparation of Transmucosal or Transdermal Patches with Acyclovir and Lidocaine

“…Literature proves that thermal analysis techniques are methods used in the physico-chemical characterization of various materials used in the pharmaceutical industry. Thermal analysis techniques such as differential scanning calorimetry (DSC), differential thermal analysis (DTA), and Thermogravimetry (TG) are widely used in studies of pre-formulation, drugs, and substance development of pharmaceutical interest [ 26 , 27 ]. Thermal analysis techniques are used in many studies to study incompatibilities between active substances: excipients [ 28 , 29 , 30 , 31 ] and also Pharmacopeias described the thermal analysis methods as general techniques.…”