Thermoplastic polyurethane—The material used for the erlanger silver catheter

Hentschel, Thomas; Münstedt, Helmut

doi:10.1007/bf02561617

Cited by 18 publications

(10 citation statements)

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“…Thermoplastic polyurethane (TPU) is a biocompatible and biodegradable elastomer that has been approved by the FDA, and has been widely applied in biomedical science [ 9 , 10 ]. It has been reported that TPU can be used for catheters, vascular grafts and drug delivery carriers [ 11 – 13 ]. Moreover, TPU also exhibits remarkable chemical stability and good mechanical properties [ 10 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing

Liu

Chen

et al. 2018

J Nanobiotechnol

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BackgroundDeveloping an ideal wound dressing that meets the multiple demands of good biocompatibility, an appropriate porous structure, superior mechanical property and excellent antibacterial activity against drug-resistant bacteria is highly desirable for clinical wound care. Biocompatible thermoplastic polyurethane (TPU) membranes are promising candidates as a scaffold; however, their lack of a suitable porous structure and antibacterial activity has limited their application. Antibiotics are generally used for preventing bacterial infections, but the global emergence of drug-resistant bacteria continues to cause social concerns.ResultsConsequently, we prepared a flexible dressing based on a TPU membrane with a specific porous structure and then modified it with a biomimetic polydopamine coating to prepare in situ a nano-silver (NS)-based composite via a facile and eco-friendly approach. SEM images showed that the TPU/NS membranes were characterized by an ideal porous structure (pore size: ~ 85 μm, porosity: ~ 65%) that was decorated with nano-silver particles. ATR-FITR and XRD spectroscopy further confirmed the stepwise deposition of polydopamine and nano-silver. Water contact angle measurement indicated improved surface hydrophilicity after coating with polydopamine. Tensile testing demonstrated that the TPU/NS membranes had an acceptable mechanical strength and excellent flexibility. Subsequently, bacterial suspension assay, plate counting methods and Live/Dead staining assays demonstrated that the optimized TPU/NS2.5 membranes possessed excellent antibacterial activity against P. aeruginosa, E. coli, S. aureus and MRSA bacteria, while CCK8 testing, SEM observations and cell apoptosis assays demonstrated that they had no measurable cytotoxicity toward mammalian cells. Moreover, a steady and safe silver-releasing profile recorded by ICP-MS confirmed these results. Finally, by using a bacteria-infected (MRSA or P. aeruginosa) murine wound model, we found that TPU/NS2.5 membranes could prevent in vivo bacterial infections and promote wound healing via accelerating the re-epithelialization process, and these membranes had no obvious toxicity toward normal tissues.ConclusionBased on these results, the TPU/NS2.5 nanocomposite has great potential for the management of wounds, particularly for wounds caused by drug-resistant bacteria.

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Section: Introductionmentioning

confidence: 99%

Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing

Liu

Chen

et al. 2018

J Nanobiotechnol

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“…Bioresorbable PU scaffolds have attracted considerable attention and their great potential in tissue engineering has been reported [28,29]. Thermoplastic polyurethane (TPU) as a class of PU has been widely employed in medical applications due to its biocompatibility and flexibility, and has been used in medical devices such as catheters [30], pace-maker leads [31], skin [32], and vascular grafts [33]. TPUs offer high elongation, moderate tensile strength and Young’s modulus, and excellent abrasion and tear resistance [34].…”

Section: Introductionmentioning

confidence: 99%

Characterization of thermoplastic polyurethane/polylactic acid (TPU/PLA) tissue engineering scaffolds fabricated by microcellular injection molding

Salick

Jing

et al. 2013

Materials Science and Engineering: C

258

176

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Polylactic acid (PLA) and thermoplastic polyurethane (TPU) are two kinds of biocompatible and biodegradable polymers that can be used in biomedical applications. PLA has rigid mechanical properties while TPU possesses flexible mechanical properties. Blended TPU/PLA tissue engineering scaffolds at different ratios for tunable properties were fabricated via twin screw extrusion and microcellular injection molding techniques for the first time. Multiple test methods were used to characterize these materials. Fourier transform infrared spectroscopy (FTIR) confirmed the existence of the two components in the blends; differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) confirmed the immiscibility between the TPU and PLA. Scanning electron microscopy (SEM) images verified that, at the composition ratios studied, PLA was dispersed as spheres or islands inside the TPU matrix and that this phase morphology further influenced the scaffold’s microstructure and surface roughness. The blends exhibited a large range of mechanical properties that covered several human tissue requirements. 3T3 fibroblast cell culture showed that the scaffolds supported cell proliferation and migration properly. Most importantly, this study demonstrated the feasibility of mass producing biocompatible PLA/TPU scaffolds with tunable microstructures, surface roughnesses, and mechanical properties that have the potential to be used as artificial scaffolds in multiple tissue engineering applications.

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“…Therefore, zeolites have attracted interest for biomedical applications, including antidiarrheal agents, hemorrhage control, detoxicants, and antibacterial agents 10. In different applications, antibacterial PU is obtained by either the coating of PU with silver13, 14 or by silver particle impregnation 15–18. Using silver‐ion‐loaded zeolites as antibacterial agents offers an advantage over the other methods because silver ions are more effective than metallic silver atoms.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of antibacterial zeolite–polyurethane composites

Kamisoglu

Aksoy

Akata

et al. 2008

J of Applied Polymer Sci

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In this study, antibacterial properties were induced in polyurethane (PU) films by the incorporation of Ag þ -loaded zeolites as fillers. The mechanical and thermal properties of the prepared composites were also investigated. For this purpose, two different types of zeolite microparticles, high-silica zeolite beta crystals and low-silica zeolite A crystals, were synthesized. Ag þ was added by ion exchange, and these particles were incorporated into the PU prepolymer, which was prepared from its main components of toluene diisocyanate and polypropylene ethylene glycol (medical purity). Microbiological tests revealed that both types of composites, prepared by the addition of Ag þ -containing zeolite beta or zeolite A to the PU matrix, had antibacterial properties. It was demonstrated for the first time that a high-silica zeolite (zeolite beta) and its composite film could be effectively employed as antibacterial materials. Furthermore, mechanical and thermal characterization of the composites showed that the zeolites enhanced the mechanical properties of the polymer and did not cause any deterioration in its thermal properties.

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Thermoplastic polyurethane—The material used for the erlanger silver catheter

Cited by 18 publications

References 0 publications

Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing

Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing

Characterization of thermoplastic polyurethane/polylactic acid (TPU/PLA) tissue engineering scaffolds fabricated by microcellular injection molding

Preparation and characterization of antibacterial zeolite–polyurethane composites

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