Thermoresponsive and bioactive poly(vinyl ether)-based hydrogels synthesized by radiation copolymerization and photochemical immobilization

Current Understanding of the Applications of Photocrosslinked Hydrogels in Biomedical Engineering

“…At present, thevinyl molecules used in hydrogel preparations are mainly N-vinyl pyrrolidone (NVP). NVP itself has low viscosity, high reactivity, and limitedskin irritation [11], so it is widely used as a typical ethylene molecule [12]. Kao et al first reported NVP photocrosslinking with four different comonomers to prepare a series of UV-curable bioadhesives with a high water uptake ranging from 25 to 350 wt% [13].…”

Surface Chemoselective Phototransformation of C–H Bonds on Organic Polymeric Materials and Related High-Tech Applications

“…In this way, a photoreactive azide is first inserted into a C–H bond on a polymer surface, resulting in the grafting of NHS groups that can subsequently react with amine-terminated (usually at the N-terminus) functional peptides through NHS displacement. − For example, PDMS surface has been modified through phenylazide-induced C–H phototransformation to introduce NHS ester groups (Figure ), and then RGD peptides are conjugated on the reactive surface allowing a promotion of the adhesion, proliferation, and collagen production of human skin fibroblasts (HSFs) . In another approach, the linker is used to photochemically immobilize RGD in a thermosensitive hydrogel formed by copolymerization of ethylene glycol vinyl ether and butyl vinyl ether . The thermoresponsive character of the hydrogel enables this material to recover the attached viable cells from the surface of the hydrogel by a simple low-temperature treatment without the use of trypsin.…”

Electron beam immobilization of functionalized poly(vinyl methyl ether) thin films on polymer surfaces – Towards stimuli responsive coatings for biomedical purposes

“…The distinct thermo-responsive behavior with a LCST only a few Kelvin below the standard cell cultivation temperature predestines PVME as a coating for thermo-responsive cell culture carriers. However, there are only few studies on the application of polyvinylether based hydrogels for this purpose [11]. Contrary to PNiPAAm, PVME possesses a high affinity to electron beam cross-linking [12,13].…”