Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy

Purushotham, S.; Ramanujan, R.V.

doi:10.1016/j.actbio.2009.07.004

Cited by 237 publications

(170 citation statements)

References 55 publications

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“…Except for the abovementioned MNC devices, drug encapsulated magnetic cationic liposome (MCL) and thermoresponsive core-shell MNPs are also under intensive investigation for the bi-modal therapy of combined hyperthermia with chemotherapy (Shinkai 2004;Purushotham 2010). The nanocomposite devices exhibit advantageous feature for a facilitated drug delivery from the nano-carriers and the magnetic mediated heating potential is adequate for hyperthermic treatments.…”

Section: Resultsmentioning

confidence: 99%

Magnetic Nanocomposite Devices for Cancer Thermochemotherapy

Zhao¹,

Wang²,

Yang³

et al. 2011

Advances in Nanocomposites - Synthesis, Characterization and Industrial Applications

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Section: Resultsmentioning

confidence: 99%

Magnetic Nanocomposite Devices for Cancer Thermochemotherapy

Zhao¹,

Wang²,

Yang³

et al. 2011

Advances in Nanocomposites - Synthesis, Characterization and Industrial Applications

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“…After removal of free polymer from the reaction mixture, the polymer coated cubic-IONPs were observed to be soluble in water or phosphate buffered saline (PBS) (pH 7.4) at room temperature. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 As we sought to prepare thermo-responsive IONPs for cancer treatment with thermal response significant for hyperthermia (41-47 o C) , 15,32 we targeted coil-globule response temperatures above body temperature (37 o C) and maintaining this behavior in physiological conditions (saline buffer solutions at 155 mM of...…”

Section: Polymerization Reaction Of Thermo-responsive Shell On the Ramentioning

confidence: 99%

Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)Responsive Coating and Their Application in Hyperthermia and Heat-Triggered Drug Delivery

Kakwere

Leal

Materia

et al. 2015

ACS Appl. Mater. Interfaces

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Herein we prepare nanohybrids by incorporating iron oxide nanocubes (cubic-IONPs) within a thermo-responsive polymer shell that can act as drug carriers for doxorubicin(doxo). The cubic-shaped nanoparticles employed are at the interface between superparamagnetic and ferromagnetic behavior and have an exceptionally high specific absorption rate (SAR) but their functionalization is extremely challenging compared to bare superparamagnetic iron oxide nanoparticles as they strongly interact with each other. By conducting the polymer grafting reaction using reversible addition-fragmentation chain transfer (RAFT) polymerization in a viscous solvent medium, we have here developed a facile approach to decorate the nanocubes with stimuli-responsive polymers. When the thermo-responsive shell is composed of poly(N-isopropyl acrylamide-co-polyethylene glycolmethylether acrylate), nanohybrids have a phase transition temperature, the lower critical solution temperature (LCST), above 37 °C in physiological conditions. Doxo loaded nanohybrids exhibited a negligible drug release below 37 °C but showed a consistent release of their cargo on demand by exploiting the capability of the nanocubes to generate heat under an alternating magnetic field (AMF). Moreover, the drug free nanocarrier does not 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 exhibit cytotoxicity even when administered at high concentration of nanocubes (1g/L of iron) and internalized at high extent (260 pg of iron per cell). We have also implemented the synthesis protocol to decorate the surface of nanocubes with poly(vinylpyridine) polymer and thus prepare pH-responsive shell coated nanocubes.

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“…From the combination strategy, advantage can be taken from the already observed additive effect of hyperthermia in combination with chemotherapy, in comparison to respective single treatments [14,37]. Few examples reported up to now represent the design of cisplatin- [2,21] or doxorubicin- [28,29] loaded MNPs. Apart from that, the largest number of studies are dealing with drugs coupled to MNPs exclusively for magnetic drug targeting purposes.…”

Section: Design Of Mnps As Multifunctional Tools For Magnetic Hyperthmentioning

confidence: 99%

Means to increase the therapeutic efficiency of magnetic heating of tumors

Kettering

Grau

Pömpner

et al. 2015

Biomedical Engineering / Biomedizinische Technik

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Abstract:The treatment of tumors via hyperthermia has gained increased attention in the last years. Among the different modalities available so far, magnetic hyperthermia has the particular advantage of offering the possibility of depositing the heating source directly into the tumor. In this study, we summarized the present knowledge we gained on how to improve the therapeutic efficiency of magnetic hyperthermia using magnetic nanoparticles (MNPs), with particular consideration of the intratumoral infiltration of the magnetic material. We found that (1) MNPs will be mainly immobilized at the tumor area and that this aspect has to be considered when estimating the heating potential of MNPs, (2) the intratumoral distribution patterns via slow infiltration might well be modulated by specific MNP coating and magnetic targeting, (3) imaging of the nanoparticle depositions within the tumor might allow to correct the distribution pattern via multiple applications, (4) multiple therapeutic sessions are feasible because MNPs are not delivered from the tumor site during the heating process, (5) the utilization of MNPs that internalize into cells will favor the production of intracellular heating spots rather than extracellular ones, (6) utilization of MNPs functionalized with chemotherapeutic agents will allow us to exploit the additive effects of both therapeutic modalities, and (7) distinct cytopathological and histopathological alterations in target tissues are induced as a result of magnetic hyperthermia. However, the accumulation at the tumor via intravenous application remains a matter of challenge.

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Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy

Cited by 237 publications

References 55 publications

Magnetic Nanocomposite Devices for Cancer Thermochemotherapy

Magnetic Nanocomposite Devices for Cancer Thermochemotherapy

Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)Responsive Coating and Their Application in Hyperthermia and Heat-Triggered Drug Delivery

Means to increase the therapeutic efficiency of magnetic heating of tumors

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