Thermoresponsive Shape‐Memory Hydrogel Actuators Made by Phototriggered Click Chemistry

Maiti, Binoy; Abramov, Alex; Franco, Lourdes; Puiggalı́, Jordi; Enshaei, Hamidreza; Alemán, Carlos; Díaz, David Díaz

doi:10.1002/adfm.202001683

Cited by 40 publications

(26 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the cysteine (Cys) containing disulfide bond ( Yang et al, 2015 ; Wang et al, 2020 ) was reasonably chosen to possess the GSH-responsive peculiarity. On the other hand, a polymer pre-monomer containing the photo-click functional groups, including methacryloyl (MA) ( Maiti et al, 2020 ) and tetrazolium (Tet) ( Wu et al, 2019 ; Liu et al, 2021 ), was designed and synthesized to obtain a controllable nano-delivery system.…”

Section: Resultsmentioning

confidence: 99%

Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis

Zheng

Long²,

Chen

et al. 2022

Front. Mol. Biosci.

View full text Add to dashboard Cite

Tuberculosis (TB) is a virulent form of an infectious disease that causes a global burden due to its high infectivity and fatality rate, especially the irrepressible threats of latent infection. Constructing an efficient strategy for the prevention and control of TB is of great significance. Fortunately, we found that granulomas are endowed with higher reducibility levels possibly caused by internal inflammation and a relatively enclosed microenvironment. Therefore, we developed the first targeted glutathione- (GSH-) responsive theranostic system (RIF@Cy5.5-HA-NG) for tuberculosis with a rifampicin- (RIF-) loaded near-infrared emission carrier, which was constructed by photoclick reaction-actuated hydrophobic-hydrophobic interaction, enabling the early diagnosis of tuberculosis through granulomas-tracking. Furthermore, the loaded rifampicin was released through the dissociation of disulfide bond by the localized GSH in granulomas, realizing the targeted tuberculosis therapy and providing an especially accurate treatment mapping for tuberculosis. Thus, this targeted theranostic strategy for tuberculosis exhibits the potential to realize both granulomas-tracking and anti-infection of tuberculosis.

show abstract

Section: Resultsmentioning

confidence: 99%

Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis

Zheng

Long²,

Chen

et al. 2022

Front. Mol. Biosci.

View full text Add to dashboard Cite

show abstract

“…Because of their unique shape-recovery function, SMPs have broad application prospects in many fields, including biological medical devices, aerospace engineering, textiles, and anti-counterfeiting [ 4 , 5 , 6 ]. Thermally induced SMP is an important branch of shape-memory polymer stimulation that has been widely studied and has many industrial applications [ 7 , 8 , 9 ]. As an important component of thermally induced SMPs, trans-1,4-polyisoprene (TPI) and its composites have been used in biomedical and protective equipment applications due to their fast deformation speed, high recovery rate, and high recovery accuracy [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Trans-1,4-Polyisoprene Shape-Memory Polymer Composites Reinforced with Carbon Nanotubes Modified by Polydopamine

Zhang

Xin

et al. 2021

Polymers

View full text Add to dashboard Cite

In this study, which was inspired by mussel-biomimetic bonding research, carbon nanotubes (CNTs) were interfacially modified with polydopamine (PDA) to prepare a novel nano-filler (CNTs@PDA). The structure and properties of the CNTs@PDA were studied using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). The CNTs and the CNTs@PDA were used as nanofillers and melt-blended into trans-1,4 polyisoprene (TPI) to create shape-memory polymer composites. The thermal stability, mechanical properties, and shape-memory properties of the TPI/CNTs and TPI/CNTs@PDA composites were systematically studied. The results demonstrate that these modifications enhanced the interfacial interaction, thermal stability, and mechanical properties of TPI/CNTs@PDA composites while maintaining shape-memory performance.

show abstract

“…In our previous report we have reported thermoresponsive hydrogel membranes by combining glycerol ethoxylate based trialkyne and different diazide monomers using photo‐ triggered Cu(I)‐catalysed click chemistry [22] . In this present work we tried to avoid the extra synthetic step which was followed in the previous report (to make different diazide and dialkyne) and showed a very easy and straightforward method to synthesize novel thermoresponsive polyurethane from glycerol ethoxylate, which is a tri‐arm PEG and dicyclohexyl diisocyanate in a one pot system.…”

Section: Introductionmentioning

confidence: 99%

Efficient One‐Pot Preparation of Thermoresponsive Polyurethanes with Lower Critical Solution Temperatures

et al. 2021

Self Cite

View full text Add to dashboard Cite

This work reports a simple and scalable strategy to prepare a series of thermoresponsive polyurethanes synthesized via copolymerization of dicyclohexyl diisocyanate with glycerol ethoxylate in a single one‐pot system. These polyurethanes exhibit lower critical solution temperatures (LCST) at 57 °C. The LCST of synthesized polyurethane was determined from Dynamic Scanning Calorimetry and UV‐vis measurements. Both the LCST and Tg of synthesized polyurethane was tuned by varying the ratio between hard segment (dicyclohexyl diisocyanate) and soft segment (glycerol ethoxylate). Thus, Tg values could be tuned from −54.6 °C to −19.9 °C for samples with different flexibility. The swelling and deswelling studies were done at room temperature and above the LCST respectively. The results showed that the swelling ratio increases with the increase of soft segment (glycerol ethoxylate) in synthesized polyurethanes. Furthermore, the mechanical properties of the membrane were studied by universal tensile testing measurements. Specifically, stress at break values varied from 0.35±0.07 MPa to 0.91±0.15 MPa for the tested membranes, whereas elongation at break data ranged from 101.9±20.9 % to 192.4±24.4 %, and Young's modulus varied from 0.35±0.03 MPa to 1.85±0.19 MPa. Tensile strength of the films increased with the increase of the hard segment and elongation at break decreased.

show abstract

Thermoresponsive Shape‐Memory Hydrogel Actuators Made by Phototriggered Click Chemistry

Cited by 40 publications

References 44 publications

Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis

Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis

Development of Trans-1,4-Polyisoprene Shape-Memory Polymer Composites Reinforced with Carbon Nanotubes Modified by Polydopamine

Efficient One‐Pot Preparation of Thermoresponsive Polyurethanes with Lower Critical Solution Temperatures

Contact Info

Product

Resources

About