Thermosensitive Cotton Textile Loaded with Cyclodextrin-complexed Curcumin as a Wound Dressing

Sun, Xiaozhu; Wu, Junzi; Wang, Haidong; Chang, Guan Jun

doi:10.1007/s12221-021-0334-1

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…Hydrogel wound dressings hold great potential in eliminating bacteria and accelerating the healing process [5][6][7]. To tackle bacterial infections at the wound site and create a better pro-healing microenvironment, various antibacterial agents (i.e., curcumin [8], polypeptide nisin [9]) and antibiotics (i.e., penicillin, vancomycin, and gentamicin) were integrated into hydrogel wound dressings to achieve efficient antibacterial effects, which would inevitably lead to unpredictable side effects. In addition, drug activity cannot be ensured during the entire complex woundhealing process [10,11].…”

Section: Introductionmentioning

confidence: 99%

Cotton Fabric-Reinforced Hydrogels with Excellent Mechanical and Broad-Spectrum Photothermal Antibacterial Properties

Yuan,

Zhang,

Shi

et al. 2024

Polymers

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Antibacterial hydrogel wound dressings hold great potential in eliminating bacteria and accelerating the healing process. However, it remains a challenge to fabricate hydrogel wound dressings that simultaneously exhibit excellent mechanical and photothermal antibacterial properties. Here we report the development of polydopamine-functionalized graphene oxide (rGO@PDA)/calcium alginate (CA)/Polypyrrole (PPy) cotton fabric-reinforced hydrogels (abbreviated as rGO@PDA/CA/PPy FHs) for tackling bacterial infections. The mechanical properties of hydrogels were greatly enhanced by cotton fabric reinforcement and an interpenetrating structure, while excellent broad-spectrum photothermal antibacterial properties based on the photothermal effect were obtained by incorporating PPy and rGO@PDA. Results indicated that rGO@PDA/CA/PPy FHs exhibited superior tensile strength in both the warp (289 ± 62.1 N) and weft directions (142 ± 23.0 N), similarly to cotton fabric. By incorporating PPy and rGO@PDA, the swelling ratio was significantly decreased from 673.5% to 236.6%, while photothermal conversion performance was significantly enhanced with a temperature elevated to 45.0 °C. Due to the synergistic photothermal properties of rGO@PDA and PPy, rGO@PDA/CA/PPy FHs exhibited excellent bacteria-eliminating efficiency for S. aureus (0.57%) and E. coli (3.58%) after exposure to NIR for 20 min. We believe that the design of fabric-reinforced hydrogels could serve as a guideline for developing hydrogel wound dressings with improved mechanical properties and broad-spectrum photothermal antibacterial properties for infected-wound treatment.

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Section: Introductionmentioning

confidence: 99%

Cotton Fabric-Reinforced Hydrogels with Excellent Mechanical and Broad-Spectrum Photothermal Antibacterial Properties

Yuan,

Zhang,

Shi

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

“…Hydrogel wound dressings hold great potential in eliminating bacteria and accelerating the healing process [3][4][5]. To tackle bacterial infections at the wound site and create a better pro-healing microenvironment, various antibacterial agents (i.e., curcumin [6], polypeptide nisin [7]) and 2 antibiotics (i.e., penicillin, vancomycin, and gentamicin) were integrated into hydrogel wound dressings to achieve efficient antibacterial effects, which would inevitably lead to unpredictable side effects. In addition, drug activity cannot be ensured during the entire complex wound-healing process [8,9].…”

Section: Introductionmentioning

confidence: 99%

Cotton Fabric-Reinforced Hydrogels with Excellent Mechanical and Broad-Spectrum Photothermal Antibacterial Properties

Yuan,

Zhang,

Shi

et al. 2024

Preprint

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Hydrogel wound dressings hold great potential in eliminating bacteria and accelerating the healing process. However, it remains a challenge to fabricate hydrogel wound dressings that simultaneously exhibit excellent mechanical and photothermal antibacterial properties. Here we report the development of polydopamine-functionalized graphene oxide/calcium alginate/Polypyrrole cotton fabric-reinforced hydrogels (abbreviated as rGO@PDA/CA/PPy FHs) for tackling bacterial infections. The mechanical properties of hydrogels were greatly enhanced by cotton fabric reinforcement and an interpenetrating structure, while excellent broad-spectrum photothermal antibacterial properties based on the photothermal effect were obtained by incorporating PPy and rGO@PDA. Results indicated that rGO@PDA/CA/PPy FHs exhibited superior tensile strength in both the warp (289±62.1N) and weft directions (142±23.0N) similar to cotton fabric. By incorporating PPy and rGO@PDA, the swelling ratio was significantly decreased from 673.5% to 236.6%, while photothermal conversion performance was significantly enhanced with a temperature elevated to 45.0 ℃. Due to the synergistic photothermal properties of rGO@PDA and PPy, rGO@PDA/CA/PPy FHs exhibited excellent bacteria-eliminating efficiency for S. aureus (0.57%) and E. coli (3.58%) after exposure to NIR for 20 min. We believe that the design of fabric-reinforced hydrogels could serve as a guideline for developing hydrogel wound dressings with improved mechanical properties and broad-spectrum photothermal antibacterial properties for infected wound treatment.

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“…Sol–gel-transformed hydrogels are proposed to attract many researchers for wound dressing materials . Among them, thermosensitive gels are special in dressings, which respond to an environmental temperature at a critical transition temperature and make the dressing hydrogels easy to bandage and remove. , PNIPAM is a well-known polymer for temperature-sensitive hydrogel in the biomedical field . The low critical solution temperature (LCST) of poly( N -isopropylacrylamide) (PNIPAM) is 32 °C, close to human body temperature .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Low-Temperature Fast Gelation β-Cyclodextrin-Based Hydrogel-Loaded Medicine for Wound Dressings

Shen,

Fu,

Liu

et al. 2023

Biomacromolecules

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β-Cyclodextrin (β-CD) is often used as a drug carrier for biomedical materials due to its unique cavity structure. Herein, β-CD was modified by acryloyl chloride and further copolymerized with N-isopropylacrylamide (NIPAM) and acrylic acid (AA) to obtain PNIPAM-co-β-CD-AC. The results showed that the critical phase transition temperature of PNIPAM/β-CD-AC could be controlled at 19 °C, and the fast sol−gel phase transition was realized in 2−10 s. The hydrophobic drug carried in this hydrogel can constantly be released for more than 6 days at pH values (pH 5.5−8), and the duration may match the recovery of the wound. As a dressing hydrogel, its rapid gel formation and inversion as well as shearthinning behavior prevent secondary wound damage. The β-CD-based hydrogel also has good biocompatibility and antioxidant properties, which provide a good potential choice for wound dressings, especially for exposed wounds in winter.

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Thermosensitive Cotton Textile Loaded with Cyclodextrin-complexed Curcumin as a Wound Dressing

Cited by 6 publications

References 44 publications

Cotton Fabric-Reinforced Hydrogels with Excellent Mechanical and Broad-Spectrum Photothermal Antibacterial Properties

Cotton Fabric-Reinforced Hydrogels with Excellent Mechanical and Broad-Spectrum Photothermal Antibacterial Properties

Cotton Fabric-Reinforced Hydrogels with Excellent Mechanical and Broad-Spectrum Photothermal Antibacterial Properties

Fabrication of Low-Temperature Fast Gelation β-Cyclodextrin-Based Hydrogel-Loaded Medicine for Wound Dressings

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