Thermosensitive Hydrogel Mask Significantly Improves Skin Moisture and Skin Tone; Bilateral Clinical Trial

Quattrone, Anna; Czajka, Anna; Sibilla, Sara

doi:10.3390/cosmetics4020017

Cited by 29 publications

(21 citation statements)

References 82 publications

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“…Although interest in using SDDS for skin application has already been demonstrated in the literature, for the moment, only a few of those systems have been marketed [ 72 ]. This slow incorporation of smart nanocarriers in the market could be explained by several factors: Most materials are synthesized under poorly reproducible conditions, and the methods to prepare smart SDDS are not standardized.…”

Section: Discussionmentioning

confidence: 99%

“…For cutaneous delivery, several strategies are available: Using the temperature difference between the formulation (usually at room temperature) and the skin surface (32 °C). For example, when thermoresponsive system is applied to the skin surface and reaches its temperature, it will quickly release the drug [ 72 , 73 ]. Using the thermal gradient of the skin (32–37 °C) to deliver drugs.…”

Section: Polymer-based Smart Drug Delivery Systems For Topical Applicationsmentioning

confidence: 99%

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Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

et al. 2021

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Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Polymer-based Smart Drug Delivery Systems For Topical Applicationsmentioning

confidence: 99%

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

et al. 2021

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“…It is claimed that these masks hydrate the skin, restore its elasticity, and promote anti-aging performance. Superabsorbent hydrogels, in particular acrylate-based materials, are extensively applied in hygiene products to absorb fluids as they are able to keep moisture away from skin, promote skin health, prevent diaper rash, and provide comfort [ 90 , 127 ].…”

Section: Polymeric Gels and Their Propertiesmentioning

confidence: 99%

Polymeric Gels and Their Application in the Treatment of Psoriasis Vulgaris: A Review

Kulawik‐Pióro

Miastkowska

2021

IJMS

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Psoriasis is a chronic skin disease, and it is especially characterized by the occurrence of red, itchy, and scaly eruptions on the skin. The quality of life of patients with psoriasis is decreased because this disease remains incurable, despite the rapid progress of therapeutic methods and the introduction of many innovative antipsoriatic drugs. Moreover, many patients with psoriasis are dissatisfied with their current treatment methods and the form with which the drug is applied. The patients complain about skin irritation, clothing stains, unpleasant smell, or excessive viscosity of the preparation. The causes of these issues should be linked with little effectiveness of the therapy caused by low permeation of the drug into the skin, as well as patients’ disobeying doctors’ recommendations, e.g., concerning regular application of the preparation. Both of these factors are closely related to the physicochemical form of the preparation and its rheological and mechanical properties. To improve the quality of patients’ lives, it is important to gain knowledge about the specific form of the drug and its effect on the safety and efficacy of a therapy as well as the patients’ comfort during application. Therefore, we present a literature review and a detailed analysis of the composition, rheological properties, and mechanical properties of polymeric gels as an alternative to viscous and greasy ointments. We discuss the following polymeric gels: hydrogels, oleogels, emulgels, and bigels. In our opinion, they have many characteristics (i.e., safety, effectiveness, desired durability, acceptance by patients), which can contribute to the development of an effective and, at the same time comfortable, method of local treatment of psoriasis for patients.

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“…A lack of hydration can lead to dry and scaly skin; causing irritation and inflammation conditions such as eczema and psoriasis . Decreased moisture can also reduce skin elasticity; hindering the skins ability to keep its shape . The complex structure and composition of the epidermis can affect the moisturisation levels of skin .…”

Section: Introductionmentioning

confidence: 99%

Engineering optimisation of commercial facemask formulations capable of improving skin moisturisation

Mehta

Picken

White

et al. 2019

Intern J of Cosmetic Sci

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Introduction The stratum corneum is the biggest obstacle in cosmetics with respect to skin moisturisation. Many approaches have been taken to overcome the barrier, one of which is incorporating natural cosmeceuticals into cosmetic products to enhance moisturisation effects. Here, a commercial facemask formulation was electrospun to develop dry facemasks capable of hosting cosmeceuticals within the pores of incorporated mesoporous silica. Methods Ethanolic solutions containing 40% w/w of the marketed facemask (7th Heaven Dead Sea peel‐off facemask) and mesoporous silica were prepared and electrically processed at 30 μL min−1 at an applied voltage of 12 ± 2 kV. In vitro characterisation and release studies using fluorescein dye as a model probe were carried out. Results SEM images confirmed the fibrous nature of the resulting matrix; showing an average fiber diameter of 298.32 nm. The electrospun mask was found to be advantageous due to this fibrous nature providing high active loading capacity whilst demonstrating 100% probe release within 60 min. Contact Angle hysteresis, thermal analysis and Fourier Transform Infrared Spectroscopy (FTIR) presented evidence of compatibility and stability of and within the formulation. Conclusion Adapting the formulation of a commercial polymeric facemask into an electrospun facemask has shown the versatility of the electrospinning process; now successfully crossing over into the cosmetic industry.

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Thermosensitive Hydrogel Mask Significantly Improves Skin Moisture and Skin Tone; Bilateral Clinical Trial

Cited by 29 publications

References 82 publications

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymeric Gels and Their Application in the Treatment of Psoriasis Vulgaris: A Review

Engineering optimisation of commercial facemask formulations capable of improving skin moisturisation

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