Thermosensitive hydrogel used in dual drug delivery system with paclitaxel-loaded micelles for in situ treatment of lung cancer

Wu, Zhi‐Ying; Zou, Xiaoyan; Yang, Linglin; Lin, Sheng; Fan, Juan; Yang, Bo; Sun, Xiaoyang; Wan, Qiang; Chen, Yue; Fu, Shaozhi

doi:10.1016/j.colsurfb.2014.06.052

Cited by 59 publications

(49 citation statements)

References 31 publications

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“…The rapid drug release by free PTX indicated that the dialysis membrane had no effect on retarding the release of the drug from nanoparticles, also underlining that PTX-NPs drug release mechanisms are diffusion, erosion and swelling of the polymer matrix, as well as its degradation (Zhang & Feng, 2006). The burst release of PTX in other studies (Wu et al, 2014) may be due to the dissolution and diffusion of the drug that was poorly entrapped in the polymer matrix. Some studies have reported that the NPs cumulative drug release within one month is usually 30-40% or less, which may be too slow to meet the therapeutic needs (Mu & Feng, 2002;Zhang & Feng, 2006).…”

Section: Discussionmentioning

confidence: 90%

“…Methyl alcohol/ acetonitrile/water (38.1/23.8/38.1, v/v/v) was used in its mobile phase with a flow rate of 1.0 ml/min. Drug-loading and EE were calculated using the following equations, as previously described (Wu et al, 2014):…”

Section: Drug-loading (Dl) and Encapsulation Efficiency (Ee) Of Ptx-npsmentioning

confidence: 99%

“…The solubilization of PTX is more effective in vitro and in vivo than Taxol Õ in many solid tumors (Passarella et al, 2010;Xin et al, 2010;Guo et al, 2011;Yang et al, 2011;Jung et al, 2012;Lv et al, 2012;Yoshizawa et al, 2012;Zhang et al, 2012Zhang et al, , 2014Lu et al, 2013b;Wu et al, 2014;You et al, 2016). In addition, with the development of nanotechnology, methoxy poly(ethylene glycol)-poly(e-caprolactone) (MPEG-PCL) polymeric micelle appears a promising drug carrier, since it is biodegradable, effective, and possesses sustained drug release properties (Wang C et al, 2011;Ding et al, 2012;Gong et al, 2013;Wu et al, 2014;You et al, 2016). Its hydrophobic surface (PCL chains) forms a core for attaching hydrophobic drugs, while the hydrophilic one (PEG chains) forms a shell to act as a stabilizing interface (Gong et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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In vivo synergistic anti-tumor effect of paclitaxel nanoparticles combined with radiotherapy on human cervical carcinoma

Yu¹,

Xu²,

You³

et al. 2017

Drug Delivery

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In this study, our purpose was to explore the synergistic anti-tumor effect and mechanism of paclitaxel nanoparticles (PTX-NPs) combined with radiotherapy (RT) on human cervical carcinoma (HeLa). PTX-NPs were prepared by a solid dispersion method using methoxy poly(ethylene glycol)-poly(e-caprolactone) (MPEG-PCL), which combined with RT exerted a potent and high efficient effect against cervical cancer. In vivo antitumor activity of PTX-NPs combined with RT, was estimated using nude mice carrying Hela cell xenograft tumor. The results were evaluated using microfluorine-18-deoxyglucose PET/computed tomography ( 18 F-FDG PET/CT) and immunohistochemistry. The results showed that PTX-NPs possessed a more efficient effect than PTX when combined with RT (p50.05). PTX-NPs in combination with RT might inhibit cell proliferation through its action on Ki-67, and decreased micro-vessel density (MVD) associated with CD31 and vascular endothelial growth factor (VEGF). These results suggested that PTX-NPs possessed a synergistic anti-tumor effect against cervical cancer when combined with RT.

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Section: Discussionmentioning

confidence: 90%

Section: Drug-loading (Dl) and Encapsulation Efficiency (Ee) Of Ptx-npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vivo synergistic anti-tumor effect of paclitaxel nanoparticles combined with radiotherapy on human cervical carcinoma

Yu¹,

Xu²,

You³

et al. 2017

Drug Delivery

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“…Wu et al 80 developed an interesting gel-based dual-drug delivery system by combining a cisplatin-containing thermosensitive hydrogel and paclitaxel-loaded polymeric micelles. In this study, the size distribution of the micelles loaded with paclitaxel was characterized by DLS and AFM.…”

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confidence: 99%

Physicochemical characterization of drug nanocarriers

Manaia

Abuçafy

Chiari-Andréo

et al. 2017

IJN

142

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Pharmaceutical design has enabled important advances in the prevention, treatment, and diagnosis of diseases. The use of nanotechnology to optimize the delivery of drugs and diagnostic molecules is increasingly receiving attention due to the enhanced efficiency provided by these systems. Understanding the structures of nanocarriers is crucial in elucidating their physical and chemical properties, which greatly influence their behavior in the body at both the molecular and systemic levels. This review was conducted to describe the principles and characteristics of techniques commonly used to elucidate the structures of nanocarriers, with consideration of their size, morphology, surface charge, porosity, crystalline arrangement, and phase. These techniques include X-ray diffraction, small-angle X-ray scattering, dynamic light scattering, zeta potential, polarized light microscopy, transmission electron microscopy, scanning electron microcopy, and porosimetry. Moreover, we describe some of the commonly used nanocarriers (liquid crystals, metal–organic frameworks, silica nanospheres, liposomes, solid lipid nanoparticles, and micelles) and the main aspects of their structures.

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“…Therefore, a novel drug delivery system that results in a higher concentration of drugs in the tumor, an increased retention time, and reduced side effects is clearly warranted. Due to their high local drug concentration and low levels of systemic toxicity, injectable in situ-forming hydrogels, such as poly(ethylene glycol)-poly(E-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) have been extensively studied as novel drug delivery systems (DDSs) in recent years (Fang et al, 2009;Na et al, 2012;Lin et al, 2014;Wu et al, 2014). Degradable polymers are of interest as DDSs because of their ability to increase water solubility and anti-tumor effects of hydrophobic chemotherapeutic agents, such as monomethyl poly(ethylene glycol)-poly(e-caprolactone) (mPEG-PCL) Wu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Novel composite drug delivery system as a novel radio sensitizer for the local treatment of cervical carcinoma

Tang

et al. 2017

Drug Delivery

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In this study, we investigated in vivo radiosensitizing effects of a gel-based dual drug delivery system (DDS) (PECE/DDP + mPEG-PCL/PTX, or PDMP) in a cervical cancer model, and determined its possible mechanisms of action. A xenograft cervical cancer model was used to investigate the radio sensitization effect of PDMP. Mice underwent paclitaxel (PTX) + cisplatin (DDP), PECE, or PDMP treatment followed by single radiation doses ranging from 0 Gy to 20 Gy. Radio sensitization was analyzed by tumor regrowth delay (TGD). The sensitization enhancement ratio (SER) was calculated by the doses needed to yield TGD when using radiation treatment alone and when using radiation plus drug treatment. The impact of irradiation and drugs on TGD was determined, and an optimum radiation dose was chosen for further evaluation of radio sensitizing effects. The data showed that PDMP yielded the highest radio sensitization (SER was 1.3) and a radiation dose of 12 Gy was chosen for further investigation. PDMP + radiotherapy treatment was most effective in inhibiting tumor growth, prolonging survival time, decreasing expression of CD31, CD133, and aldehyde dehydrogenase 1 (ALDH1), inducing G2/M phase arrest, apoptosis, and expression of Ataxia telangiectasia mutated (ATM) and histone H2AX phosphorylation (γ-H2AX). Thus, our data indicated that PDMP is a promising anti-tumor and radio sensitization reagent for the treatment of cervical carcinoma.

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Thermosensitive hydrogel used in dual drug delivery system with paclitaxel-loaded micelles for in situ treatment of lung cancer

Cited by 59 publications

References 31 publications

In vivo synergistic anti-tumor effect of paclitaxel nanoparticles combined with radiotherapy on human cervical carcinoma

In vivo synergistic anti-tumor effect of paclitaxel nanoparticles combined with radiotherapy on human cervical carcinoma

Physicochemical characterization of drug nanocarriers

Novel composite drug delivery system as a novel radio sensitizer for the local treatment of cervical carcinoma

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