Thermosensitive mucoadhesive gel formulation loaded with 5-Fu: cyclodextrin complex for HPV-induced cervical cancer

Bilensoy, Erem; Çirpanli, Yasemin; Şen, Murat; Doğan, Aydın; Çalış, Sema

doi:10.1007/s10847-006-9259-y

Cited by 72 publications

(32 citation statements)

References 33 publications

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“…Differential scanning calorimetric (DSC) analysis was generally performed to characterize inclusion complexes with β-CD by comparing the thermal behaviors of the individual components as well as their physical mixtures and inclusion compounds [20–22]. DSC is a rapid and reliable way to screen naringin and β-CD compatibility.…”

Section: Resultsmentioning

confidence: 99%

Effect of β-Cyclodextrin Complexation on Solubility and Enzymatic Conversion of Naringin

Cui

Zhang

Sun

et al. 2012

IJMS

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In the present paper, the effect of β-cyclodextrin (β-CD) inclusion complexation on the solubility and enzymatic hydrolysis of naringin was investigated. The inclusion complex of naringin/β-CD at the molar ratio of 1:1 was obtained by the dropping method and was characterized by differential scanning calorimetry. The solubility of naringin complexes in water at 37 ± 0.1 °C was 15 times greater than that of free naringin. Snailase-involved hydrolysis conditions were tested for the bioconversion of naringin into naringenin using the univariate experimental design. Naringin can be transformed into naringenin by snailase-involved hydrolysis. The optimum conditions for enzymatic hydrolysis were determined as follows: pH 5.0, temperature 37 °C, ratio of snailase/substrate 0.8, substrate concentration 20 mg·mL−1, and reaction time 12 h. Under the optimum conditions, the transforming rate of naringenin from naringin for inclusion complexes and free naringin was 98.7% and 56.2% respectively, suggesting that β-CD complexation can improve the aqueous solubility and consequently the enzymatic hydrolysis rate of naringin.

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Section: Resultsmentioning

confidence: 99%

Effect of β-Cyclodextrin Complexation on Solubility and Enzymatic Conversion of Naringin

Cui

Zhang

Sun

et al. 2012

IJMS

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“…Bilensoy et al [120] formulated 5-FU vaginal gel using the thermosensitive polymer Pluronic F127 together with alternative mucoadhesive polymers, e.g. hyaluronic acid, Carbopol 934, and hydroxypropyl methylcellulose, to achieve a better therapeutic efficacy and patient compliance for the treatment of HPV-induced cervical cancers.…”

Section: Localized Drug Delivery Systemsmentioning

confidence: 99%

“…No.Drug/therapy/functional groupType/Composition of gelCell lines /animal models/neoplasmReferences1.PaclitaxelPoly- N -isopropylacrylamide, tert-butyl 2-acrylamidoethyl carbamate and N -hydroxyethyl acrylamideMCF7, T47D, and HeLa cells[115]2.DoxorubicinFe 3 O 4 magnetic nanoparticle-incorporated poly-( N -isopropylacrylamide)-chitosan-based nanohydrogelsHeLa cells[116]3.Photothermal therapyHydrogel system containing polyacrylamide-based nanoparticlesHeLa cells[117]4.DoxorubicinCryogel formulations based on chitosan-gelatin, chitosan-agarose and chitosan-agarose gelatinHeLa cells[118]5.Arginine-glycine-aspartic acid-serineMagnetic iron oxide nanoparticles coated with polyethylene glycol hydrogelHeLa cells[119]6.5-fluorouracilPluronic F127 together with alternative mucoadhesive polymers, e.g. hyaluronic acid, Carbopol 934, and hydroxypropyl methylcelluloseHeLa cells[120]7.PaclitaxelTemperature-sensitive poly(organophosphazene)–PTX conjugateHeLa cells and nude mice[121]8.Doxorubicin, cyclophosphamide and cisplatinChitosan hydrogelMice containing TC-1 cervical cells[122]9.5-aminolevulinic acid (5-ALA) ester hexylamionolevulinatePoloxamer 407Cervical intraepithelial neoplasia[123,124] …”

Section: Localized Drug Delivery Systemsmentioning

confidence: 99%

Possible role of nanocarriers in drug delivery against cervical cancer

Gupta

2017

Nano Reviews & Experiments

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Introduction: Cervical cancer is the second most common cancer and the largest cancer killer among women in most developing countries including India. Although, various drugs have been developed for cervical cancer, treatment with these drugs often results in a number of undesirable side effects, toxicity and multidrug resistance (MDR). Also, the outcomes for cervical cancer patients remain poor after surgery and chemo radiation. Methods: A literature search (for drugs and delivery systems against cervical cancer) was performed on PubMed and through Google. The present review discuss about various methods including its current conventional treatment with special reference to recent advances in delivery systems encapsulating various anticancer drugs and natural plant products for targeting towards cervical cancer. The role of photothermal therapy, gene therapy and radiation therapy against cervical cancer is also discussed. Results: Systemic/targeted drug delivery systems including liposomes, nanoparticles, hydrogels, dendrimers etc. and localized drug delivery systems like cervical patches, films, rings etc. are safer than the conventional chemotherapy which has further been proved by the several drug delivery systems undergoing clinical trials. Conclusion: Novel approaches for the aggressive treatment of cervical cancer will optimistically result in decreased side effects as well as toxicity, frequency of administration of existing drugs, to overcome MDR and to increase the survival rates.

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“…DSC analysis was performed to characterize inclusion complexes with α-CD by comparing the thermal behavior of the individual components as well as their individual components [12][13][14].…”

Section: Dsc Studiesmentioning

confidence: 99%

INCLUSION STUDIES ON Α-Cyclodextrin COMPLEXES OF GLIPIZIDE AND GLICLAZIDE WITH EFFECT OF PH

Simon

Kumari²

2016

Asian J Pharm Clin Res

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Objective: To synthesize inclusion complexes of oral antidiabetic drugs, i.e., Glipizide (GP) and Gliclazide (Glc) with a-cyclodextrin (α-CD) and varying the pH which will enhance the solubility and thereby oral bioavailability of the drugs.Methods: Liquid inclusion complexes were prepared and characterized by ultraviolet-visible (UV-VIS) spectroscopic studies, and fluorescent studies solid inclusion complexes of GP and Glc with α-CD were prepared by co-evaporation method and characterized by differential scanning calorimetric studies (DSC) and 1 H nuclear magnetic resonance spectroscopic studies ( 1 H NMR). Results:The inclusion complexes of both GP and Glc with α-CD showed high binding constant values for pH 2 from the UV-VIS spectroscopy studies and fluorescent studies. DSC and 1 H NMR spectroscopic studies confirmed the inclusion of GP and Glc inside the α-CD cavity. Conclusion:Formed with more stable inclusion complexes, with α-CD are GP and Glc at pH 2, along with pH modulation could be a suitable strategy to enhance the solubility and oral bioavailability of both the drugs.

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Thermosensitive mucoadhesive gel formulation loaded with 5-Fu: cyclodextrin complex for HPV-induced cervical cancer

Cited by 72 publications

References 33 publications

Effect of β-Cyclodextrin Complexation on Solubility and Enzymatic Conversion of Naringin

Effect of β-Cyclodextrin Complexation on Solubility and Enzymatic Conversion of Naringin

Possible role of nanocarriers in drug delivery against cervical cancer

INCLUSION STUDIES ON Α-Cyclodextrin COMPLEXES OF GLIPIZIDE AND GLICLAZIDE WITH EFFECT OF PH

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