Thermosensitive polysaccharide particles for pulmonary drug delivery

Sato, Takumi; Takami, Taku; Saito, Hiromu; Murakami, Yoshihiko

doi:10.1016/j.colsurfa.2019.123720

Cited by 9 publications

(6 citation statements)

References 63 publications

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“…The CRG(CS(Ns), Mb) and CRG(PLL(Ns), Mb) microparticles were prepared according to a previously reported method [27]. Here, A(m, n) refers to microparticle A that contains nanoparticle m and compound n inside them.…”

Section: Preparation Of the Crg(cs(ns) Mb) And Crg(pll(ns) Mb) Microp...mentioning

confidence: 99%

“…An aqueous polysaccharide solution was prepared by dissolving κ-CRG (2.5 w/v%), ι-CRG (2.5 w/v%), potassium chloride (32 mM), and Mb (7.3 mM) in Milli-Q water (70 • C, 40 mL). A mixture of κ-CRG and ι-CRG was used instead of κ-CRG or ι-CRG alone because the mixture gelates rapidly with moderate rigidity [27]. The organic solvent was prepared by dissolving PEG-b-PCL (0.5 mM) in toluene (10 mL).…”

Section: Preparation Of the Crg(cs(ns) Mb) And Crg(pll(ns) Mb) Microp...mentioning

confidence: 99%

“…Furthermore, these cationic nanoparticles can contain anionic compounds, also through electrostatic interactions. Therefore, the previously developed carrageenan microparticles [27] can contain positively charged compounds, whereas the microparticles developed in this study facilitate the concurrent containment of negatively charged compounds through complexation with cationic nanoparticles. The carrageenan microparticles designed based on this idea should exhibit two-step release behavior; that is, the nanoparticles and compounds dispersed inside the microparticles are released in a temperature-responsive manner, followed by the release of another compound from within the nanoparticles (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…We previously developed temperature-responsive carrageenan microparticles that are efficiently delivered to the lungs [27]. These particles, which are readily prepared by the solgel transition of carrageenan, can rapidly release their inclusions by collapsing in response to temperature.…”

Section: Introductionmentioning

confidence: 99%

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Temperature-Responsive Polysaccharide Microparticles Containing Nanoparticles: Release of Multiple Cationic/Anionic Compounds

Sato

Murakami

2022

Materials

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Most drug carriers used in pulmonary administration are microparticles with diameters over 1 µm. Only a few examples involving nanoparticles have been reported because such small particles are readily exhaled. Consequently, the development of microparticles capable of encapsulating nanoparticles and a wide range of compounds for pulmonary drug-delivery applications is an important objective. In this study, we investigated the development of polysaccharide microparticles containing nanoparticles for the temperature-responsive and two-step release of inclusions. The prepared microparticles containing nanoparticles can release two differently charged compounds in a stepwise manner. The particles have two different drug release pathways: one is the release of nanoparticle inclusions from the nanoparticles and the other is the release of microparticle inclusions during microparticle collapse. The nanoparticles can be efficiently delivered deep into the lungs and a wide range of compounds are released in a charge-independent manner, owing to the suitable roughness of the microparticle surface. These polysaccharide microparticles containing nanoparticles are expected to be used as temperature-responsive drug carriers, not only for pulmonary administration but also for various administration routes, including transpulmonary, intramuscular, and transdermal routes, that can release multiple drugs in a controlled manner.

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Section: Preparation Of the Crg(cs(ns) Mb) And Crg(pll(ns) Mb) Microp...mentioning

confidence: 99%

Section: Preparation Of the Crg(cs(ns) Mb) And Crg(pll(ns) Mb) Microp...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Temperature-Responsive Polysaccharide Microparticles Containing Nanoparticles: Release of Multiple Cationic/Anionic Compounds

Sato

Murakami

2022

Materials

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“…Sato et al prepared temperature-responsive polysaccharide particles through the formation of an emulsion and the subsequent sol–gel transformation of polysaccharides. It was found that sunken κ-carrageenan particles may remain in the alveoli, and were likely to produce significant therapeutic effects in pulmonary administration [ 44 ].…”

Section: Carrageenan and Its Derivativesmentioning

confidence: 99%

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

et al. 2020

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In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed.

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Formulation strategies, preparation methods, and devices for pulmonary delivery of biologics

Berkenfeld,

Carneiro,

Corzo

et al. 2024

European Journal of Pharmaceutics and Biopharmaceutics

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Thermosensitive polysaccharide particles for pulmonary drug delivery

Cited by 9 publications

References 63 publications

Temperature-Responsive Polysaccharide Microparticles Containing Nanoparticles: Release of Multiple Cationic/Anionic Compounds

Temperature-Responsive Polysaccharide Microparticles Containing Nanoparticles: Release of Multiple Cationic/Anionic Compounds

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

Formulation strategies, preparation methods, and devices for pulmonary delivery of biologics

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