Thermosensitive selenium hydrogel boosts antitumor immune response for hepatocellular carcinoma chemoradiotherapy

Liu, Chang; Lin, Run; Lai, Haoqiang; Pi, Fen; Xue, Qian; Chen, Tianfeng; He, Weiling

doi:10.1016/j.nantod.2023.101823

Cited by 13 publications

(3 citation statements)

References 47 publications

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“…Selenium (Se) is a micronutrient acting as an inflammation, oxidant, and tumor suppressor in humans. , The paucity of selenium throughout the metabolism is bound up with Keshan disease, malignant tumors, and infertility. − Notably, prior studies have highlighted its extraordinary effects in abrogating hepatocellular carcinoma, colon cancer, prostate cancer, lung cancer, and even H1N1 virus infection through ROS-induced apoptosis. , Selenadiazole, a synthetic agent, exerts an antiproliferation function in human breast adrenocarcinoma MCF-7 cells and is also a radiosensitizer in melanoma A375 cell. , In MCF-7, selenadiazole elicits an overabundance of oxidants and DNA fragmentation, thus activating caspase, Bcl-2, and other pro-apoptosis proteins. Simultaneously, selenadiazole enhances the sensitivity of radiotherapy by eliciting G2/M cell cycle arrest and ascending the ROS level, which synergistically hinders cancerous activity.…”

Section: Introductionmentioning

confidence: 99%

“… 10 − 12 Notably, prior studies have highlighted its extraordinary effects in abrogating hepatocellular carcinoma, colon cancer, prostate cancer, lung cancer, and even H1N1 virus infection through ROS-induced apoptosis. 13 , 14 Selenadiazole, a synthetic agent, exerts an antiproliferation function in human breast adrenocarcinoma MCF-7 cells and is also a radiosensitizer in melanoma A375 cell. 15 , 16 In MCF-7, selenadiazole elicits an overabundance of oxidants and DNA fragmentation, thus activating caspase, Bcl-2, and other pro-apoptosis proteins.…”

Section: Introductionmentioning

confidence: 99%

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Selenadiazole-Induced Hela Cell Apoptosis through the Redox Oxygen Species-Mediated JAK2/STAT3 Signaling Pathway

Yuan,

Li,

Deng

et al. 2024

ACS Omega

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Cervical cancer is a significant global health concern, and novel therapeutic strategies are continually being sought to combat this disease. In recent years, selenadiazole found latent therapeutic effects on tumors. Herein, investigating the mechanism of selenadiazole in Hela cells holds promise for advancing cervical cancer treatment. Hela cells, a widely utilized model for studying cervical cancer, were treated with selenadiazole, and cell viability was assessed by using the cell counting kit-8 (CCK-8) assay. Changes in mitochondrial membrane potential were evaluated using JC-1 staining, while apoptosis induction was examined using AnnexinV−PI double staining. Intracellular ROS levels were measured by using specific fluorescent probes and the ELIASA system. Additionally, Western blotting was performed to assess the activation of related proteins in response to selenadiazole. Data analysis was performed using GraphPad. Exposure to selenadiazole led to a substantial increase in intracellular redox oxygen species (ROS) levels in Hela cells. Importantly, the induction of ROS by selenadiazole was associated with a marked increase in mitochondrial apoptosis, as evidenced by elevated levels of AnnexinV-positive cells, the JC-1 monomer, caspase-9, and Bcl-2. Furthermore, activation of the JAK2/STAT3 pathway was observed following the selenadiazole treatment. Selenadiazole holds the potential to suppress tumor growth in cervical cancer cells by increasing reactive oxygen species (ROS) levels and inducing mitochondrial apoptosis via the JAK2/STAT3 pathway. This study offers valuable insights into potential cervical cancer therapies and underscores the need for further research into the specific mechanisms of selenadiazole.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selenadiazole-Induced Hela Cell Apoptosis through the Redox Oxygen Species-Mediated JAK2/STAT3 Signaling Pathway

Yuan,

Li,

Deng

et al. 2024

ACS Omega

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“…[ 1–3 ] HCC has gradually been thought of as a death sentence due to its high incidence and mortality, however, mounting evidence indicates that this is indeed the case. [ 4–8 ] HCC results in nearly one million deaths annually all over the world since the majority of HCC patients can only be diagnosed at the late stage, missing the best treatment time. [ 9,10 ] Fortunately, numerous cancers can be cured with increased survival rates if diagnosed early.…”

Section: Introductionmentioning

confidence: 99%

Ketocyanine‐Based Fluorescent Probe Revealing the Polarity Heterogeneity of Lipid Droplets and Enabling Accurate Diagnosis of Hepatocellular Carcinoma

He,

Yan,

Sun

et al. 2024

Adv Healthcare Materials

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Hepatocellular carcinoma (HCC) has gradually become a pronoun for terrifying death owing to its high mortality rate. With the progression of HCC, lipid droplets (LDs) in HCC cells exhibit specific variations such as increased LDs number and decreased polarity, which can serve as the diagnostic target. However, developing an effective method to achieve HCC diagnosis and reveal LDs polarity heterogeneity is still a crucial challenge. Herein, we report the first high‐performance LDs‐targeting probe (1) based on ketocyanine strategy with ultrasensitive polarity‐responding ability and near‐infrared emission. Probe 1 shows excellent sensitivity to polarity parameter Δf (0.027 to 0.290) with 808‐fold fluorescence enhancement and the emission wavelength red‐shifts 91 nm. In HCC cells, probe 1 shows a 2.5‐ to 5.9‐fold fluorescence enhancement compared with normal and other cancer cells which exceeds clinical threshold of 2.0, indicating probe 1 can distinguish HCC cells. We have revealed the LDs polarity heterogeneity and it displays a sequence, HCC cells < other cancer cells < normal cells, which may provide useful insight to engineer LDs‐targeting probes for HCC cell discrimination. Finally, probe 1 realizes accurate HCC diagnosis on the cellular, organ, and in vivo levels, providing a satisfying tool for clinical HCC diagnosis and surgical navigation.This article is protected by copyright. All rights reserved

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Overheated Self‐Managing Cellulose Nanocage Dressing by Reconstructing Hydrogen Bonds Networks

Chen,

Lu,

Sun

et al. 2024

Adv Funct Materials

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Interfacing intelligent responsive molecules with biocompatible nanofibers is a promising strategy for developing overheated self‐managing photothermal dressings for convenient and cost‐effective clinical applications. Here, an anisotropic staggered cellulose nanocage dressing with overheated self‐managing properties is constructed by temperature‐responsive flexible triblock copolymer Pluronic® F‐127 interpenetrating with smart cellulose nanofiber network skeleton, which interfaced with white light (635 nm) responsive protoporphyrin IX, and NIR‐I (808 nm) responsive dopamine, NIR‐II (980 nm) responsive upconversion nanoparticles. Ingeniously, the dressing can release 1O2 and produce heat energy under the stimulation by continuous natural light and NIR‐I laser during the anti‐inflammation phase, respectively, and further promote the formation of new capillaries by producing NO during the epithelial formation stage under NIR‐II laser. Interestingly, the dressing, which resembled water droplets, can penetrate and adapt to irregular wounds via sol–gel transformation at 32 °C, while also facilitating intelligent management of the self‐cooling regulation via the reconstruction of its hydrogen bond network driven by overheating temperatures (>50 °C). The proposed method overcomes the shortcoming of requiring auxiliary strategies for temperature monitoring, providing new insights for guiding the design of practical dressings.

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Thermosensitive selenium hydrogel boosts antitumor immune response for hepatocellular carcinoma chemoradiotherapy

Cited by 13 publications

References 47 publications

Selenadiazole-Induced Hela Cell Apoptosis through the Redox Oxygen Species-Mediated JAK2/STAT3 Signaling Pathway

Selenadiazole-Induced Hela Cell Apoptosis through the Redox Oxygen Species-Mediated JAK2/STAT3 Signaling Pathway

Ketocyanine‐Based Fluorescent Probe Revealing the Polarity Heterogeneity of Lipid Droplets and Enabling Accurate Diagnosis of Hepatocellular Carcinoma

Overheated Self‐Managing Cellulose Nanocage Dressing by Reconstructing Hydrogen Bonds Networks

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