Thiabendazolium Nitrate, an Anthelmintic Compound

Abstract

In the crystal structure of 2-(thiazol-4-yl)-lH-benzimidazolium nitrate, CIoH8N3S+.NOS, the benzimidazole moiety is protonated. The benzimidazole and thiazole systems are coplanar. Both N--H groups of the protonated benzimidazole are involved in N--H--.O hydrogen bonds with the nitrate anion.

Chloridobis[2-(1,3-thiazol-4-yl-κN)-1H-benzimidazole-κN3]cobalt(II) chloride dihydrate

“…For related structures, see: Devereux et al (2004,2007); Flores-Alamo et al (2010); Jean et al (2002); Mothilal et al (2004); Murugesan et al (1998); Ren et al (2010); Stanley et al (2002); Trus & Marsh (1973); Wisniewski et al (2001).…”

“…Thiabendazole had been studied for a long time. The crystal structures of thiabendazole (Trus & Marsh, 1973), thiabendazolium nitrate (Murugesan et al, 1998), thiabendazolium chlorate (Stanley et al, 2002), and a lot of its metal compounds (Devereux et al, 2004(Devereux et al, , 2007Flores-Alamo et al, 2010;Jean et al, 2002;Mothilal et al, 2004;Ren et al, 2010;Wisniewski et al, 2001) have been reported.…”

2-(1,3-Thiazol-4-yl)benzimidazolium nitrate monohydrate

“…For the antiviral action and anthelmintic activity of substituted benzimidazoles, see: Goodgame et al (1985). Related structures have been reported: thiabendazole (Trus & Marsh, 1973); thiabendazolium nitrate (Murugesan et al, 1998;Devereux et al, 2004); thiabendazolium perchlorate (Stanley et al, 2002); thiabendazolium halide dihydrates (Prabakaran et al, 2000). For structures of transition metal complexes bearing thiabendazole as ligand, see: Kowala & Wunderlich (1973); Udupa & Krebs (1979); Rong et al (1991).…”

“…The crystal structures of thiabendazole (Trus & Marsh, 1973), thiabendazolium nitrate (Murugesan et al, 1998;Devereux et al, 2004), thiabendazolium perchlorate (Stanley et al, 2002), thiabendazolium halide dihydrates (Prabakaran et al, 2000), and its complexes with cobalt (Kowala & Wunderlich, 1973), copper (Udupa & Krebs, 1979) and platinum (Rong et al, 1991) have been reported. The present paper deals with the crystal structure of a protonated thiabendazole moiety, namely, thiabendazolium nitrate hydrate.…”