Thiacloprid impairs honeybee worker learning and memory with inducing neuronal apoptosis and downregulating memory-related genes

Li, Airui; Yin, Linghong; Li, Ke; Diao, Qingyun; Wu, Yanyan; Dai, Pingli; Liu, Yongjun

doi:10.1016/j.scitotenv.2023.163820

Cited by 15 publications

(12 citation statements)

References 129 publications

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“…We showed that chronic larval exposure to thiacloprid impaired honey bee response to sucrose in emerged bees along with olfactory associative learning and memory performance. The results are consistent with previous research that indicated thiacloprid adversely affected honey bee cognitive performance [ 17 , 24 ]. Sucrose sensitivity was used as an important indicator of foraging efficiency.…”

Section: Discussionsupporting

confidence: 93%

“…Our results showed larval thiacloprid exposure affected the learning acquisition and memory retention of emerged bees. Similar adverse effects on learning and memory have been mentioned in previous research on adult bees (honey bee or stingless bees) exposed to thiacloprid [11,16,24]. Furthermore, these findings demonstrated that despite surviving to adulthood, honey bee larvae exposed to thiacloprid experience cognitive disorders after emerging, which aligns with the impaired olfactory associative behavior identified in honey bees exposed to imidacloprid or thiacloprid [17].…”

Section: Thiacloprid Impaired Honey Bee Learning and Memory Abilitysupporting

confidence: 85%

“…Our study aimed to assess the response of adult honey bees to thiacloprid contamination in their early larval stage, even though the toxicity of thiacloprid has been extensively studied in adult bees. We provided evidence supporting the chronic toxicity of thiacloprid in honey bees [ 14 , 23 , 24 ]. Exposure to thiacloprid during the larval stage resulted in reduced survival rates and body weight.…”

Section: Introductionmentioning

confidence: 69%

“…The maximum DMSO concentration used in our thiacloprid exposure dose was 0.01%, which should not affect the physiological status of honey bees. Additionally, our previous results [ 24 ] showed that 0.02% DMSO had no impact on cell apoptosis. Therefore, we did not include a solvent control (DMSO group) in this study.…”

Section: Methodsmentioning

confidence: 90%

“…Honey bee decline is correlated with the use of neonicotinoid insecticides [ cloprid, a widely used neonicotinoid, has been found at high field-realistic levels pollen and nectar [30]. Studies have shown the adverse effects of thiacloprid on ho health [12,17,24], foraging [16], homing [31], social abilities [32], and cognitive b [33].…”

Section: Discussionmentioning

confidence: 99%

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Early-Life Sublethal Thiacloprid Exposure to Honey Bee Larvae: Enduring Effects on Adult Bee Cognitive Abilities

Chen,

Li,

Yin

et al. 2023

Toxics

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Honey bees have significant ecological and economic value as important pollinators, but they are continuously exposed to various environmental stressors, including insecticides, which can impair their health and cause colony decline. (1) Background: Cognitive abilities are vital for the functional maintenance of honey bees; however, it remains unknown if chronic, low-dose exposure to thiacloprid during the larval stage impairs the cognitive abilities of emerged adult honey bees. (2) Methods: To explore this question, honey bee larvae were fed 0, 0.5, and 1.0 mg/L thiacloprid during their developmental phase. Then, the cognitive (i.e., olfactory learning and memory) abilities of adult honey bees were quantified to assess the delayed impacts of early-stage thiacloprid exposure on adult honey bee cognition. Neural apoptosis and transcriptomic level were also evaluated to explore the neurological mechanisms underlying these effects. (3) Results: Our results revealed that chronic larval exposure to sublethal thiacloprid impaired the learning and memory abilities of adult honey bees by inducing neuronal apoptosis and transcriptomic alterations. (4) Conclusions: We highlighted a previously unknown impairment caused by thiacloprid in honey bees.

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Section: Discussionsupporting

confidence: 93%

Section: Thiacloprid Impaired Honey Bee Learning and Memory Abilitysupporting

confidence: 85%

Section: Introductionmentioning

confidence: 69%

Section: Methodsmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Early-Life Sublethal Thiacloprid Exposure to Honey Bee Larvae: Enduring Effects on Adult Bee Cognitive Abilities

Chen,

Li,

Yin

et al. 2023

Toxics

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The effects of anthropogenic toxins on honey bee learning: Research trends and significance

DesJardins,

Harrison,

Smith

2023

Apidologie

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Managed honey bees are experiencing high rates of colony loss, in part due to widespread exposure to agrochemicals and other environmental toxins. The ability to learn about relevant environmental stimuli is an important skill necessary for foraging and navigation, although it is sometimes impaired in bees that have been exposed to toxins or other stressors. Here, we review the effects of anthropogenic toxins (which we divide into five major classes: insecticides, acaricides, biopesticides, other agrochemicals, and other toxins) on learning performance in European honey bees. We discuss the general trends of these studies, including that neurotoxic insecticides are overwhelmingly the most well-studied, and that most studies focus on acute exposure of individual, adult bees to a single toxin. Protocols for field-relevant exposure vary widely among labs, and we make suggestions to aid in the standardization of future studies. We review the relevance of learning studies for toxicological risk assessment, concluding that they are valuable tools for assessing sublethal behavioral effects of toxins. Their inclusion in risk assessment studies would be an improvement over current procedures, which focus largely on lethality.

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Thiacloprid-silica nano-delivery system enhances toxicity against Aphis gossypii and improves non-target biosafety

Yan,

Shan,

et al. 2024

Chemosphere

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Thiacloprid impairs honeybee worker learning and memory with inducing neuronal apoptosis and downregulating memory-related genes

Cited by 15 publications

References 129 publications

Early-Life Sublethal Thiacloprid Exposure to Honey Bee Larvae: Enduring Effects on Adult Bee Cognitive Abilities

Early-Life Sublethal Thiacloprid Exposure to Honey Bee Larvae: Enduring Effects on Adult Bee Cognitive Abilities

The effects of anthropogenic toxins on honey bee learning: Research trends and significance

Thiacloprid-silica nano-delivery system enhances toxicity against Aphis gossypii and improves non-target biosafety

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