Thiamine for Septic Shock: Take Your Vitamins?

The Challenges of Using and Measuring Thiamine in Critical Care

“…Finally, we concur with Fujii and Sevransky in their editorial that the “gold” measurement for thiamine is indeed whole blood ( 5 ). Thiamine diphosphate, as the bioactive form of thiamine, is present in negligible amounts in plasma, whereas whole-blood thiamine makes up 80% of total circulating thiamine and is therefore a good derivative of whole-body stores of thiamine ( 6 ).…”