Thiamine in excitable tissues: Reflections on a non-cofactor role

Bettendorff, Lucien

doi:10.1007/bf01991194

Cited by 65 publications

(44 citation statements)

References 176 publications

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“…Its involvement in these metabolic pathways and its intracellular abundance has made TPP a popular analyte for assessing thiamine status. However, there are also proposed non-cofactor roles of thiamine compounds within the immune system, gene regulation, oxidative stress response, cholinergic activity, chloride channels and neurotransmission [8,[56][57][58][59][60][61].…”

Section: Physiology Of Thiaminementioning

confidence: 99%

“…For the interested reader, papers by Betterndorf [56], Lonsdale [9] and Manzetti [8] provide excellent overviews of thiamine in both cofactor and non-cofactor roles. Recent discoveries have also identified thiamine containing adenine nucleotides, but as there is little known in regard to their function and mechanisms they will not be discussed further in this review [10].…”

Section: Physiology Of Thiaminementioning

confidence: 99%

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Vitamin B1 in critically ill patients: needs and challenges

Collie

Greaves

Jones

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Thiamine has a crucial role in energy production, and consequently thiamine deficiency (TD) has been associated with cardiac failure, neurological disorders, oxidative stress (lactic acidosis and sepsis) and refeeding syndrome (RFS). This review aims to explore analytical methodologies of thiamine compound quantification and highlight similarities, variances and limitations of current techniques and how they may be relevant to patients. Content: An electronic search of Medline, PubMed and Embase databases for original articles published in peerreviewed journals was conducted. MethodsNow was used to search for published analytical methods of thiamine compounds. Keywords for all databases included "thiamine and its phosphate esters", "thiamine methodology" and terms related to critical illness. Enquiries were also made to six external quality assurance (EQA) programme organisations for the inclusion of thiamine measurement.

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Section: Physiology Of Thiaminementioning

confidence: 99%

Section: Physiology Of Thiaminementioning

confidence: 99%

Vitamin B1 in critically ill patients: needs and challenges

Collie

Greaves

Jones

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…The structure of AThTP appears to closely resemble NAD ϩ . Although the biological role of AThTP is unknown, the existence of noncoenzyme functions of thiamine derivatives has been speculated (11)(12)(13)(14).In the context of 1) structural resemblance of AThTP to NAD ϩ , 2) the experimental evidence implicating PARP-1 as a causative factor in the pathogenesis of diabetes and diabetic complications in vitro and in vivo (reviewed in Szabó ( 8 )), and 3) beneficial effects of highdose thiamine on diabetic complications, we hypothesized that AThTP could interact with PARP-1 and mod-E-mail: t.tanaka.md@gmail.com Abbreviations: AThTP, adenosine thiamine triphosphate; NAD ϩ , nicotinamide adenine dinucleotide; PARP-1, poly (ADP-ribose) polymerase-1. …”

mentioning

confidence: 99%

mentioning

confidence: 99%

Adenosine Thiamine Triphosphate (AThTP) Inhibits Poly(ADP-Ribose) Polymerase-1 (PARP-1) Activity

Tanaka

Yamamoto

Sato

et al. 2011

J Nutr Sci Vitaminol

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Summary Overactivation of poly(ADP-ribose) polymerase-1 (PARP-1) has been demonstrated to result in various stress-related diseases, including diabetes mellitus. Deficiency of cellular nicotinamide adenine dinucleotide (NAD ϩ ) content, consumed by PARP-1 to add ADP-ribose moieties onto target proteins, contributes to pathophysiological conditions. Adenosine thiamine triphosphate (AThTP) exists in small amounts in mammals; however, the function(s) of this metabolite remains unresolved. The structure of AThTP resembles NAD Substantial recent experimental studies demonstrate beneficial impacts of high-dose thiamine on diabetic complications, such as diabetic retinopathy, diabetic nephropathy, diabetic neuropathy and diabetic cardiomyopathy ( 1-4 ). However, the pharmacological relevance of high-dose thiamine treatments remains unknown.Chronic hyperglycemia results in diabetic complications in target organs. The pathogenic effect of high glucose is, at least partially, mediated to a significant extent through increased production of reactive oxygen species and reactive nitrogen species and subsequent oxidative stress (reviewed in Evans et al. ( 5 )). Increased oxidative stress activates the nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP-1). PARP-1 activation depletes its substrate, nicotinamide adenine dinucleotide (NAD ϩ ), and also covalently attaches branched nucleic acid-like polymers of poly(ADP-ribose) to various acceptor proteins (reviewed in Kiss and Szabó ( 6 )). A covalently attached ADP-ribose polymer, poly(ADP-ribosylation, affects the function of target proteins. The involvement of PARP-1 activation in the pathogenesis of diabetes and its complications has recently been emphasized by both in vivo and in vitro studies (reviewed in Pacher and Szabó ( 7 ), and Szabó ( 8 )). NAD ϩ , used as substrate for PARP-1, consists of two nucleotides joined through their phosphate groups, with one nucleotide containing an adenine base and the other containing nicotinamide.Adenosine thiamine triphosphate (AThTP), a new thiamine derivative, was recently identified in Escherichia coli ( 9 ), followed by the identification in small amounts in mouse brain, heart, skeletal muscle, liver and kidneys ( 10 ). AThTP is composed of two molecules, an adenine base and thiamine, which are joined through phosphate groups. The structure of AThTP appears to closely resemble NAD ϩ . Although the biological role of AThTP is unknown, the existence of noncoenzyme functions of thiamine derivatives has been speculated (11)(12)(13)(14).In the context of 1) structural resemblance of AThTP to NAD ϩ , 2) the experimental evidence implicating PARP-1 as a causative factor in the pathogenesis of diabetes and diabetic complications in vitro and in vivo (reviewed in Szabó ( 8 )), and 3) beneficial effects of highdose thiamine on diabetic complications, we hypothesized that AThTP could interact with PARP-1 and mod-E-mail: t.tanaka.md@gmail.com Abbreviations: AThTP, adenosine thiamine triphosphate; NAD ϩ , nicotinamide adenine dinucleotide; PARP...

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“…Nearly 20 years ago, we have reviewed data concerning a possible non-coenzyme role of thiamine or its derivatives, particularly in relation to nerve function 9 . Here, we want to critically examine the new data that have been obtained since then.…”

Section: Introductionmentioning

confidence: 99%