Thienopyrimidines Exploring the Chemistry and Bioactivity

Abstract

Thienopyrimidine is a heterocyclic compound with a thiophene ring fused to a pyrimidine ring. Due to their diverse properties and applications, these compounds are found in pharmaceuticals, agrochemicals, and materials science. The potential biological activities of thienopyridine derivatives have been investigated and utilized in medicinal chemistry. It also has diverse pharmacological activity, including anti-Alzheimer, anti-cancer, anti-fungal, anti-microbial, anthelmintic, hypolipidaemic, and anti-diabetic activity. Many commercially available drugs, including pictilisib, relugolix, and olmutinib, contain thienopyrimidine rings. This chapter focuses on the chemistry, synthetic methods, and bioactivity of different thienopyrimidines. Moreover, this chapter includes a summary of the latest information on patents and clinical trials.