Thin-section CT findings in peripheral lung cancer of 3 cm or smaller: are there any characteristic features for predicting tumor histology or do they depend only on tumor size?

Jiang, Binghu; Takashima, S; Miyake, Chie; Hakucho, Tomoaki; Takahashi, Yoshiyuki; Morimoto, Daisuke; Numasaki, Hodaka; Nakanishi, Katsuyuki; Tomita, Yoshihiro; Higashiyama, Masahiko

doi:10.1177/0284185113495834

Cited by 34 publications

(24 citation statements)

References 28 publications

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“…Similarly, spiculation is also more commonly seen in MIA (9.1%) and IAC (13.5%) lesions, compared with AIS (0%). These findings are consistent with previous studies showing that lobulation, spiculation and pleural tag are more prevalent in more advanced lung cancers (21). Air bronchogram on thin-section CT is thought to be a characteristic feature of solid adenocarcinoma of the lung.…”

Section: Discussionsupporting

confidence: 93%

Differentiating Preinvasive from Invasive Lung Adenocarcinoma Appearing as Part-Solid Ground-Glass Nodule Using CT Value and Solid-Part Diameter

Wang

Pan

et al. 2017

Iran J Radiol

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Objectives: To evaluate the differentiating roles of computed tomography (CT) for invasive adenocarcinomas (IACs) of the lung from preinvasive lesions or minimally invasive adenocarcinomas (MIAs) manifesting as part-solid ground-glass nodules (GGNs). Patients and Methods: All 230 lesions were pathologically confirmed. Their size, CT parameters and morphological features were compared among the three groups. Optimal cut-off values were calculated for parameters with diagnostic value. Results: The diameter of the GGN lesion and the maximum diameter of the solid part, as well as CT values of the ground-glass part and the solid part differed significantly among the three groups. Cut-off maximum diameter of the solid part was 2.5 and 5.5 mm to differentiate preinvasive vs. MIA and MIA vs. IAC, respectively. Cut-off mean CT value was -581 and -464 hounsfield unit (HU) to differentiate preinvasive vs. MIA and MIA vs. IAC, respectively. Cut-off CT value of the ground-glass part was -675 and -562 HU to differentiate the same three groups. Morphological characteristics such as lobulation, spiculation and air bronchograms were all more likely to occur in invasive lesions. Conclusion:The mean CT value, CT value of the ground glass part and maximum solid-part diameter of a GGN can help differentiate preinvasive from invasive lung adenocarcinomas.

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Section: Discussionsupporting

confidence: 93%

Differentiating Preinvasive from Invasive Lung Adenocarcinoma Appearing as Part-Solid Ground-Glass Nodule Using CT Value and Solid-Part Diameter

Wang

Pan

et al. 2017

Iran J Radiol

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“…Pleural indentation is a characteristic indicating a higher likelihood of malignancy not only for subsolid nodules [ 27 ], but also for solid nodules [ 28 – 30 ]. An air bronchogram is also useful for differentiating lung adenocarcinoma from benign solid nodules [ 4 , 31 ] and for predicting negative nodal involvement in solid lung cancer [ 32 ], whereas the interlobular septum is useful for differentiating intrapulmonary lymph nodes [ 33 ]. In the present study, the CT findings of pleural indentation, air bronchograms, and interlobular septa received higher scores on the U-HRCT images than on the C-HRCT images.…”

Section: Discussionmentioning

confidence: 99%

Ultra-High-Resolution Computed Tomography of the Lung: Image Quality of a Prototype Scanner

Kakinuma

Moriyama²,

Muramatsu³

et al. 2015

PLoS ONE

100

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PurposeThe image noise and image quality of a prototype ultra-high-resolution computed tomography (U-HRCT) scanner was evaluated and compared with those of conventional high-resolution CT (C-HRCT) scanners.Materials and MethodsThis study was approved by the institutional review board. A U-HRCT scanner prototype with 0.25 mm x 4 rows and operating at 120 mAs was used. The C-HRCT images were obtained using a 0.5 mm x 16 or 0.5 mm x 64 detector-row CT scanner operating at 150 mAs. Images from both scanners were reconstructed at 0.1-mm intervals; the slice thickness was 0.25 mm for the U-HRCT scanner and 0.5 mm for the C-HRCT scanners. For both scanners, the display field of view was 80 mm. The image noise of each scanner was evaluated using a phantom. U-HRCT and C-HRCT images of 53 images selected from 37 lung nodules were then observed and graded using a 5-point score by 10 board-certified thoracic radiologists. The images were presented to the observers randomly and in a blinded manner.ResultsThe image noise for U-HRCT (100.87 ± 0.51 Hounsfield units [HU]) was greater than that for C-HRCT (40.41 ± 0.52 HU; P < .0001). The image quality of U-HRCT was graded as superior to that of C-HRCT (P < .0001) for all of the following parameters that were examined: margins of subsolid and solid nodules, edges of solid components and pulmonary vessels in subsolid nodules, air bronchograms, pleural indentations, margins of pulmonary vessels, edges of bronchi, and interlobar fissures.ConclusionDespite a larger image noise, the prototype U-HRCT scanner had a significantly better image quality than the C-HRCT scanners.

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“…Aoki et al [ 13 ] showed that the frequencies of lymph node metastasis and vessel invasion in adenocarcinomas with GGO components of more than 50% were significantly lower than those in adenocarcinomas with GGO components of less than 10% obtained by thin-section CT findings. There have also been studies focusing on the relationship between CT morphologic characteristics as well as tumor size and TNM grade [ 14 - 17 ]. Bajard et al [ 18 ] showed that clinical T classification was significant for the development of brain metastasis in a cohort of 305 NSCLC patients.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis

Hwang

Park

et al. 2018

Korean J Intern Med

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Background/AimsBrain and bone metastases are common in patients with lung cancer. The development of metastasis is associated with poor survival in lung cancer patients. Although tumor morphologic features on radiographs are routinely assessed for differentiation between benign and malignant lung nodules, they are not used to predict metastasis. We assessed morphologic features of pulmonary adenocarcinomas with brain/bone metastasis on computed tomography (CT) to identify related factors for metastasis.MethodsWe performed a retrospective analysis of initial chest CT findings (size, type of contour, percentage of necrosis, enhancement, presence or absence of calcification, and air cavity) from 2009 to 2010 of patients with brain or bone metastasis and compared the findings with those of patients without metastases.ResultsIn total, 128 patients were included (78 men, 52 women; mean age 69 years; range, 36 to 87). Nineteen patients had brain metastases and 32 had bone metastases. Morphologic features associated with brain metastasis included size ≥ 50 mm (odds ratio [OR], 3.37; 95% confidence interval [CI], 1.24 to 9.17; p = 0.013), necrosis ≥ 30% (OR, 4.51; 95% CI, 1.62 to 12.55; p =0.002), and presence of calcification (OR, 3.97; 95% CI, 1.16 to 13.55; p = 0.035). Morphologic features associated with bone metastasis included necrosis ≥ 30% (OR, 4.639; 95% CI, 1.98 to 10.82; p < 0.001) and T 3 to 4 stage (OR, 2.53; 95% CI, 1.07 to 6.00; p = 0.031).ConclusionsWe found that necrosis ≥ 30% was associated with pulmonary adenocarcinoma with brain and bone metastasis at initial chest CT morphologic feature. To validate these results, further research should be conducted.

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Thin-section CT findings in peripheral lung cancer of 3 cm or smaller: are there any characteristic features for predicting tumor histology or do they depend only on tumor size?

Abstract: Air bronchogram on thin-section CT is characteristic feature of solid adenocarcinoma of the lung. However, other thin-section CT findings are irrelevant to tumor histology and related only to tumor size.

Cited by 34 publications

References 28 publications

Differentiating Preinvasive from Invasive Lung Adenocarcinoma Appearing as Part-Solid Ground-Glass Nodule Using CT Value and Solid-Part Diameter

Differentiating Preinvasive from Invasive Lung Adenocarcinoma Appearing as Part-Solid Ground-Glass Nodule Using CT Value and Solid-Part Diameter

Ultra-High-Resolution Computed Tomography of the Lung: Image Quality of a Prototype Scanner

Computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis

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