Thin-Section CT in Patients with Cystic Fibrosis: Correlation with Peak Exercise Capacity and Body Mass Index

Abstract

In patients with CF, the correlation between thin-section CT score and exercise limitation is stronger than that between spirometry results or BMI and exercise limitation.

Is Lung Clearance Index (LCI) Affected by the Severity of Lung Disease in CF?

“…It has been more sensitive than FEV 1 for early detection of CF lung disease [5,23,24,[27][28][29][30]. HRCT detects structural airways damages, but its use has been restricted due to high levels of radiation exposure [57] and it has been suggested not to perform CT scans more than once every 2 or 3 years, especially in patients without respiratory symptoms [3].…”

“…It can identify early and advanced structural damages [5,23,[27][28][29] that correlate with the disease severity and progression among CF patients [23,24,30]. Various methods have been used to quantify structural abnormalities [25,31].…”

Early oxygen uptake recovery following exercise testing in children with chronic chest diseases

“…38 Furthermore, in patients with CF the correlation between thin section computed tomographic (CT) findings of lung parenchymal damage and exercise limitation is stronger than that between spirometry results, or BMI and exercise limitation. 44 The CF genotype has also been reported to be related to exercise tolerance. 45 The aim of this study was to investigate if early The lung function data from the present study showed that FEV 1 , FVC, PEF and FEF were all significantly reduced in children with CCD compared to controls.…”

Statement on Exercise Testing in Cystic Fibrosis

“…Some evidence suggests that peak oxygen uptake determined during an incremental exercise test may better predict structural lung changes visible on thin-section CT imaging [44] and mortality [7] than FEV 1 or BMI, and that data from exercise testing may even provide information in addition to FEV 1 with respect to future decline in FEV 1 and hospitalizations [42]. …”