Think autoimmunity, breath autoimmunity, and learn autoimmunity

Toubi, Elias; Vadasz, Zahava

doi:10.1007/s10067-019-04540-2

Cited by 1 publication

(1 citation statement)

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“…This genetic association study was designed to determine the role of KIR genes in susceptibility to RA in the Lur population of Iran. Autoimmune diseases result from the failure of immune tolerance mechanisms to prevent reactions to self-antigens or unregulated activity of the immune system, both leading to tissue damage (38). NK cells detect class I HLA through their KIR cell surface receptors which, upon binding, can have different effects on the immune system in different individuals due to KIR gene polymorphism.…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid arthritis is associated with KIR2DS4-full among the KIR genes in Lur Population of Iran

et al. 2021

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Background:The pathophysiology underlying the progression and development of autoimmune conditions, such as Rheumatoid Arthritis (RA), is a result of dysregulations of the immune system. Research has explored the genetic alterations present in RA; however, limited studies have examined the role of Killer cell Immunoglobulin-like Receptors (KIR) and Human Leukocyte Antigen (HLA) molecules in RA. Therefore, the aim of this study was to examine KIR genes, their HLA ligands, and KIR-HLA compounds in patients with RA. Methods: In this case-control study, a total of 50 patients with RA and 100 healthy individuals were enrolled. DNA samples were evaluated using PCR with sequence specific Primers (PCR-SSP). Odds ratio (OR) with a 95% confidence interval (CI) were reported. Results: Among the KIR genes examined, KIR2DLA (p= 0.0255, OR= 0.389, 95% CI= 0.210-0.722) and KIR2DS4-full (p< 0.0001, OR= 6.163, 95% CI= 3.174-11.968) were observed to have a statistically significant correlation with disease susceptibility to RA. As an inhibitory gene, KIR2DLA was observed to have a protective effect against RA while KIR2DS4-full as an activating gene, was found to increase risk for RA. No significant associations were found between any of the other KIR genotypes, HLA ligands, or KIR-HLA compounds examined in this study to RA susceptibility. Conclusions: In this study of RA in the Lur population of Iran, KIR2DS4-full was observed to increase susceptibility to RA, while KIR2DL5A was found to act as a protecting factor based on both the cross Table and regression analyses. Further research should focus on repeating this study in additional populations.

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Section: Discussionmentioning

confidence: 99%