Thiolated chitosan hydrogel-embedded niosomes: A promising crocin delivery system toward the management of aphthous stomatitis

Taghizadeh, Fatemeh; Mehryab, Fatemeh; Mortazavi, Seyed Alireza; Rabbani, Shahram; Haeri, Azadeh

doi:10.1016/j.carbpol.2023.121068

Cited by 12 publications

(2 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, the thiolated chitosan hydrogel-encapsulated crocin loaded with thiolated chitosan NPs represents an option for treatment of aphthous stomatitis. 256…”

Section: Anti-inflammatory Polymeric Materials To Overcome the Oral I...mentioning

confidence: 99%

Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Jia,

Zhang,

et al. 2024

Chem. Soc. Rev.

View full text Add to dashboard Cite

show abstract

“…Overall, the thiolated chitosan hydrogel-encapsulated crocin loaded with thiolated chitosan NPs represents an option for treatment of aphthous stomatitis. 256…”

Section: Anti-inflammatory Polymeric Materials To Overcome the Oral I...mentioning

confidence: 99%

Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Jia,

Zhang,

et al. 2024

Chem. Soc. Rev.

View full text Add to dashboard Cite

show abstract

“…Therefore, there is a need to develop an effective delivery system to enhance crocin's physicochemical properties and overall efficacy. Previous research has explored various strategies, such as polymeric particles ( 6 ), nanoemulsions ( 7 ), liposomes ( 8 ), and niosomes ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Crocin-Phospholipid Complex: Molecular Docking, Molecular Dynamics Simulation, Preparation, Characterization, and Antioxidant Activity

Rezaee,

Karami

et al. 2024

Iran J Pharm Res

Self Cite

View full text Add to dashboard Cite

Background: Crocin is a water-soluble carotenoid compound present in saffron (Crocus sativus L.), known for its wide range of pharmacological activities, including cardioprotective, hepatoprotective, anti-tumorigenic, anti-atherosclerosis, and anti-inflammatory effects. Objectives: The instability of crocin, its low miscibility with oils, and poor bioavailability pose challenges for its pharmaceutical applications. This study aimed to design and prepare a crocin-phospholipid complex (CPC) and assess its physicochemical properties. Methods: The study investigated the formation of the complex and its binding affinity through molecular docking. Molecular dynamics (MD) simulations were conducted to find the optimal molar ratio of crocin to phospholipid for the complex's preparation. The CPC was produced using the solvent evaporation method. Techniques such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), field-emission scanning electron microscopy (FE-SEM), nuclear magnetic resonance (NMR), and solubility studies were utilized to characterize and confirm the formation of CPC. Additionally, the in vitro antioxidant activity of crocin and CPC was evaluated. Results: Molecular dynamic simulations explored molar ratios of 1: 1, 1: 1.5, and 1: 2 for crocin to phospholipid. The ratio of 1: 2 was found to be the most stable, exhibiting the highest probability of hydrogen bond formation. Molecular docking, FTIR, and NMR studies indicated hydrogen bond interactions between crocin and phospholipid, confirming CPC's formation. XRD and FE-SEM analyses showed a decrease in crocin's crystallinity within the phospholipid complex. Furthermore, the solubility of crocin in n-octanol was enhanced post-complexation, indicating an increase in crocin's lipophilic nature. Conclusions: Phospholipid complexation emerges as a promising technique for enhancing the physicochemical characteristics of crocin.

show abstract

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Yu,

Gao,

Liu

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, the efficient treatment of inflammation has always been the hot topic in the research of medicine. In the past decades, as a potential biomaterial, stimuli‐responsive hydrogels have been a focus of attention for the inflammation treatment due to their excellent biocompatibility and design flexibility. Recently, thanks to the rapid development of nanotechnology and material science, more and more efforts have been made to develop safer, more personal and more effective hydrogels for the therapy of some frequent but tough inflammations such as sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, and ulcerative colitis. Herein, from recent studies and articles, the conventional and emerging hydrogels in the delivery of anti‐inflammatory drugs and the therapy for various inflammations are summarized. And their prospects of clinical translation and future development are also discussed in further detail.

show abstract

Thiolated chitosan hydrogel-embedded niosomes: A promising crocin delivery system toward the management of aphthous stomatitis

Cited by 12 publications

References 60 publications

Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Crocin-Phospholipid Complex: Molecular Docking, Molecular Dynamics Simulation, Preparation, Characterization, and Antioxidant Activity

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Contact Info

Product

Resources

About