Thiolated poly(aspartic acid) as potential in situ gelling, ocular mucoadhesive drug delivery system

Horvát, Gabriella; Gyarmati, Benjámin; Berkó, Szilvia; Szabó‐Révész, Piroska; Szilágyi, Barnabas Áron; Szilágyi, András; Soós, Judit; Sandri, Giuseppina; Bonferoni, Maria Cristina; Rossi, Silvia; Ferrari, Franca; Caramella, Carla; Csányi, Erzsébet; Budai-Szűcs, Mária

doi:10.1016/j.ejps.2014.10.013

Cited by 70 publications

(65 citation statements)

References 41 publications

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“…Sustained release was observed for up to 24 hrs in the release study performed using franz diffusion cell. The results showed the importance of thiol group and the formulation can be used as in situ gels for a once daily dose administration for ocular drug delivery [69].…”

Section: Chitosan and Its Derivativesmentioning

confidence: 95%

“…Horvat et al [69], formulated sodium diclofenac containing mucoadhesive in situ gelling drug delivery system with thiolated poly (aspartic acid) (ThioPASP). ThioPASP increased the residence time of drug on ocular surface by forming disulphide linkage with glycoproteins of mucin and showed strong mucoadhesion at lower concentrations 3%, 5% w/w and addition of small amount of oxidants also improved the mucoadhesion.…”

Section: Chitosan and Its Derivativesmentioning

confidence: 99%

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Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Jain¹,

Kumar²,

Singh³

et al. 2016

JAPLR

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In situ -gelling systems has the great potential in the wide areas of drug delivery. The application areas of such systems are broad and these systems can be formulated not only as gels but also as in situ gelling nanospheres, microspheres and liposomes. To overcome the drawbacks associated with conventional drug delivery systems and take advantages of both solutions and gels, such as accurate dosing, ease of administration of the former and longer precorneal residence of the latter, a newer concept of in situ gelling drug delivery systems was came in light for the first time in the early 1980s. In situ gelling systems are the polymeric solutions which can be administered in solution form and immediately undergoes sol-gel phase transition in to a viscoelastic gel upon exposure to physiological conditions (e.g. pH, temperature and ionic concentration) or application of external triggers. In situ gelling systems seems to have wide applications in ocular therapy. A lot of research is going on in this area proves the fact that in situ gelling systems can be advantageous in the ocular drug delivery. In the present review we will discuss recent researches involving application of in situ gelling polymers, their applications in the various domains of drug delivery and marketed formulations based on in situ gelling systems.

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Section: Chitosan and Its Derivativesmentioning

confidence: 95%

Section: Chitosan and Its Derivativesmentioning

confidence: 99%

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Jain¹,

Kumar²,

Singh³

et al. 2016

JAPLR

View full text Add to dashboard Cite

show abstract

“…In recent years, various ophthalmic drug-delivery systems have been developed for ocular carriers, including liposomes (LPs), [6][7][8] nanoparticles, 9,10 microspheres, 11,12 nanostructured lipid carriers, 13,14 in situ gels, 15,16 and contact lenses. 17 Among these, LPs have proved to be a promising formulation for ocular drug transport in the last decade, because they include enclosed vesicles and bilayer structures.…”

Section: Huang Et Almentioning

confidence: 99%

A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride

Huang¹,

Qi²,

Hou³

et al. 2017

IJN

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As a novel ion-exchange carrier with high surface area and excellent exchangeability, montmorillonite (Mt) was intercalated with betaxolol hydrochloride (BH) to form a nanocomposite and then encapsulated by liposomes (Mt-BH-LPs) for an ophthalmic drug-delivery system. The Mt-BH and Mt-BH-LPs were prepared by an acidification process and ethanol injection combined with ammonium sulfate gradient methods. The successful formation of Mt-BH and Mt-BH-LPs was verified by thermogravimetric analysis, X-ray diffraction, Fourier-transform infrared spectra, and transmission electron microscopy. Mt-BH-LPs possessed the favorable physical characteristics of encapsulation efficiency, drug loading, mean particle size, and ζ-potential. In vitro release studies indicated Mt-BH-LPs effectively maintained a relatively sustained slow release. Immortalized human corneal epithelial cell cytotoxicity, in vivo rabbit eye-irritation tests, and chorioallantoic membrane–trypan blue staining all revealed that Mt-BH-LPs had no obvious irritation on ocular tissues. A new in vitro tear-turnover model, including inserts containing human corneal epithelial cells, was designed to evaluate the precorneal retention time of Mt-BH-LPs. The results showed that Mt-BH-LPs maintained a certain BH concentration in tear fluid for a longer period than the BH solution. In vivo precorneal retention studies also indicated Mt-BH-LPs prolonged drug retention on the ocular surface more than the BH solution. Furthermore, pharmacodynamic studies showed that Mt-BH-LPs had a prolonged effect on decreasing intraocular optical pressure in rabbits. Our results demonstrated that Mt-BH-LPs have potential as an ophthalmic delivery system.

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“…The water absorption capacity of the ThioPASP gels was determined gravimetrically by a method described previously (Horvát et al, 2015c). 20% w/w mixtures of ThioPASP with oxidant (1 M NaBrO 3, 20% w/w) were measured.…”

Section: Swellingmentioning

confidence: 99%

“…The measurements were performed by a method described previously (Horvát et al, 2015c). Ex vivo tests were made on excised porcine conjunctiva placed on the acceptor chamber and simulated lacrimal fluid was streamed through the donor chamber.…”

Section: 'Wash Away' Measurementmentioning

confidence: 99%

Mucoadhesive polymers in ophthalmic therapy

Horvát¹

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Thiolated poly(aspartic acid) as potential in situ gelling, ocular mucoadhesive drug delivery system

Cited by 70 publications

References 41 publications

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride

Mucoadhesive polymers in ophthalmic therapy

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