Thiols: Role in Oxidative Stress-Related Disorders

Kükürt, Abdulsamed; Gelen, Volkan; Başer, Ömer Faruk; Deveci, Hacı; Karapehlivan, Mahmut

doi:10.5772/intechopen.96682

Cited by 55 publications

(48 citation statements)

References 154 publications

(157 reference statements)

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“…Antioxidants are defined as substances that, when present in low concentrations, significantly inhibit or delay oxidative processes while oxidizing themselves, usually in relation to oxidizable substrates. They neutralize free radicals and oxidize themselves by accepting highly reactive unpaired electrons [10,[27][28][29]. It has been indicated by experimental evidence that varied antioxidants play an important role against oxidants in many studies [30][31][32][33][34][35][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

“…For example, nitric oxide (NO•), which is an RNS, is produced from 1-arginine by nitric oxide synthase and then reacts with superoxide (O2•-) to form peroxynitrite (ONOO-) [9-12]. These reactive oxygen/nitrogen species (RONS), that is, hydroxyl, superoxide anion, nitric oxide, and nitrosyl anion molecules, are highly reactive due to their unpaired valence electrons [10]. Normally, RONS have involved in cell signaling (redox signaling) pathways, thiol switches, regulation of inflammatory cytokines, growth factors, etc.…”

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confidence: 99%

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Evaluation of Oxidative Stress Index and Some Biochemical Parameters in Neonatal Calves with Diarrhea

Akyüz¹

2021

Act Sci VetSci

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Diarrhea, which is one of the most important problems of cattle breeding in the world, is most common in calves in the neonatal period [1]. The neonatal period is used to define the 28 days following birth and is the period in which the most intense diseases and deaths occur in calves. Diseases occurring in calves during this period cause significant economic losses. These economic losses are the cost of treatment, loss of yield, and decrease in potential breeding stock, as well as newborn calf deaths [2][3][4]. It is known that many factors and factors play a role in the etiology of neonatal calf diarrhea. The most important of these are negative environmental factors, maternal reasons, unsuitable care/feeding conditions, and the calf's inability to receive colostrum. In addition, the main parasitic, viral, fungal, and bacterial agents among infectious agents constitute the source of neonatal diarrhea [5][6][7][8].Oxidative stress is defined as an imbalance between the number of antioxidants and reactive oxygen species or reactive nitrogen species in a biological system. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are byproducts of various cellular processes, including aerobic metabolism. For example, nitric oxide (NO•), which is an RNS, is produced from 1-arginine by nitric oxide synthase and then reacts with superoxide (O2•-) to form peroxynitrite (ONOO-) [9-12]. These reactive oxygen/nitrogen species (RONS), that is, hydroxyl, superoxide anion, nitric oxide, and nitrosyl anion molecules, are highly reactive due to their unpaired valence electrons [10]. Normally, RONS have involved in cell signaling (redox signaling) pathways, thiol switches, regulation of inflammatory cytokines, growth factors, etc. They have important biological roles in many cellular events such as [13].

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Evaluation of Oxidative Stress Index and Some Biochemical Parameters in Neonatal Calves with Diarrhea

Akyüz¹

2021

Act Sci VetSci

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“…Moreover, their metabolic activities in cell components are impaired. Known to tissue and organ pathologies occur in the presence of oxidative stress in the organism [27][28][29][30][31][32][33][34].…”

Section: Action Mechanisms Of Insecticidesmentioning

confidence: 99%

An Overview of the Biochemical and Histopathological Effects of Insecticides

Deveci¹,

Nur²,

Deveci³

et al. 2022

Insecticides - Impact and Benefits of Its Use for Humanity

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The number of studies on insecticides, which constitute an important class of pesticides, is increasing day by day. These chemicals used in the fight against pests in the field of agriculture; It is also used to fight mosquitoes and insects in homes, gardens and rural areas. Excessive use of insecticides has adversely affected many beneficial organisms besides target organisms. As a result of the negative effects of insecticides on non-target organisms, the normal balance of nature has been disturbed and this has led to the decline of some living species in the world. In many studies from the past to the present, it has been shown that these insecticides have negative effects on the environment, human and animal health. Some of these chemicals, which have many benefits in the fight against agricultural pests, have been banned due to their harmful effects on non-target organisms as a result of excessive use. Today, however, these chemicals are still used intensively against agricultural pests, threatening non-target organisms and human health. For this reason, in this book chapter we have prepared, the negative effects of insecticides on living things are examined by reviewing biochemical and histopathological studies.

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“…Total thiols-represented by both intracellular and extracellular thiols, as well as thiols bound to proteins-are part of the protective system to counteract oxidative injury. Changes in their status have been shown to coincide with the pathogenesis of stress-associated disorders [22]. To this purpose, the content of free and protein thiols was assessed via Ellman's method after different times of incubation (12,24, and 48 h) of cells in the presence of MPE.…”

Section: Mpe Treatment Promotes a Dramatic Decrease In Thiol Group Content Changes In Mnsod Enzyme And Mitochondrial Superoxide Anion Genmentioning

confidence: 99%

Redox Imbalance and Mitochondrial Release of Apoptogenic Factors at the Forefront of the Antitumor Action of Mango Peel Extract

et al. 2021

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Today, an improved understanding of cancer cell response to cellular stress has become more necessary. Indeed, targeting the intracellular pro-oxidant/antioxidant balance triggering the tumor commitment to cell demise could represent an advantageous strategy to develop cancer-tailored therapies. In this scenario, the present study shows how the peel extract of mango—a tropical fruit rich in phytochemicals with nutraceutical properties—can affect the cell viability of three colon cancer cell lines (HT29, Caco-2 and HCT116), inducing an imbalance of cellular redox responses. By using hydro-alcoholic mango peel extract (MPE), we observed a consistent decline in thiol group content, which was accompanied by upregulation of MnSOD—a mitochondrial scavenger enzyme that modulates the cellular response against oxidative damage. Such an effect was the consequence of an early production of mitochondrial superoxide anions that appeared after just 30 min of exposure of colon cancer cells to MPE. The effect was accompanied by mitochondrial injury, consisting of the dissipation of mitochondrial membrane potential and a decrease in the level of proteins localized in the mitochondrial membrane—such as voltage-dependent anion-selective channel (VDAC1), mitofilin, and some members of Bcl-2 family proteins (Mcl-1, Bcl-2 and Bcl-XL)—with the mitochondrial release of apoptogenic factors (cytochrome C and AIF). The analysis of the cytotoxic effects exerted by the different constituents of MPE (gallic acid, mangiferin, citric acid, quinic acid, pentagalloyl glucose, and methyl gallate) allowed us to identify those phytochemicals responsible for the observed anticancer effects, sustaining their future employment as chemopreventive or therapeutic agents.

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Thiols: Role in Oxidative Stress-Related Disorders

Cited by 55 publications

References 154 publications

Evaluation of Oxidative Stress Index and Some Biochemical Parameters in Neonatal Calves with Diarrhea

Evaluation of Oxidative Stress Index and Some Biochemical Parameters in Neonatal Calves with Diarrhea

An Overview of the Biochemical and Histopathological Effects of Insecticides

Redox Imbalance and Mitochondrial Release of Apoptogenic Factors at the Forefront of the Antitumor Action of Mango Peel Extract

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