Third molar agenesis as a potential marker for craniofacial deformities

Abstract

The identification of clinical patterns of tooth agenesis in individuals born with craniofacial deformities may be a useful tool for risk determination of these defects. We hypothesize that specific craniofacial deformities are associated with third molar agenesis. Objective: The aim of this study was to identify if third molar agenesis could have a relation with other craniofacial structure alterations, such as cleft lip and palate, skeletal malocclusion, or specific growth patterns in humans. Design: Data were obtained from 550 individuals ascertained as part of studies aiming to identify genetic contributions to oral clefts. 831 dental records of patients aged over eight years seeking orthodontic treatment were also included. SN-GoGn angle were used to classify the growth pattern (hypo-divergent, normal and hyper-divergent), and the ANB angle was used to verify the skeletal malocclusion pattern (Class I, II and III). Panoramic radiographs were used to determine third molar agenesis. Results: A high frequency of third molar agenesis among individuals born with cleft lip with or without cleft palate (55%), as well as among their relatives (93.5%) was found. Third molar agenesis was not associated to skeletal malocclusion or growth pattern. Conclusion: It appears that third molar agenesis is associated with the disturbances that lead to cleft lip and palate.

Pulp enlargement in individuals born with cleft lip and palate pulp, a radiographic study from the cleft lip and palate service of paraiba, Brazil'

“…We and others have suggested that dental abnormalities outside the cleft area could serve as clinical markers for the definition of sub-phenotypes, suggesting a genetic background for such conditions (Aspinall et al 2014;Fernandez et al 2018;Küchler et al 2011;Letra et al 2007;Menezes et al 2008;Yildirim et al 2012).…”

Fisura Labio Palatina. Revisión de la Literatura

“…También se ha reportado asociación entre agenesia del tercer molar con fisura palatina y/o labio fisurado, donde Fernandez et al (2018), reportaron una alta prevalencia del 55 % en personas con agenesia de los terceros molares y nacidos con labio fisurado y/o fisura palatina, por lo que plantea que esto podría tener un alto valor predictivo de riesgo para desarrollar hendiduras.…”

Veleszületett csírahiánnyal társuló skeletalis eltérések vizsgálata

“…Ahhoz, hogy a harmadik nagyőrlő csírahiánya teljes bizonyossággal kórismézhető legyen, a csonton belüli mineralizálódása olyan szintet kell, hogy elérjen, hogy röntgenárnyék alapján ez lehetséges legyen. Későn fejlődő fogról van szó, eseteink egy része pedig 12 év alatti, amikor ez a kórisme kétséges [26,27].…”