Thirty-second sit-to-stand test as an alternative for estimating peak oxygen uptake and 6-min walking distance in women with breast cancer: a cross-sectional study

Abstract

Purpose To determine whether the 30-s sit-to-stand (30STS) test can be a valid tool for estimating and stratifying peak oxygen uptake (VO2peak) and 6-min walking distance (6MWD) in women with breast cancer. Methods This cross-sectional study uses data from the ONCORE randomized controlled trial, including 120 women aged 18–70 years with early-stage breast cancer under treatment with anthracycline and/or anti-HER2 antibodies. Participant characteristics were collected at baseline and pooled data from functional assessment (30STS test, relative and absolute VO2peak, and 6MWD) were collected at baseline and post-intervention (comprehensive cardio-oncology rehabilitation program vs. usual care). Bivariate correlations and multivariate linear regression analyses were performed to study the relationship between functional test variables. Results The number of repetitions in the 30STS test showed (i) a moderate correlation with relative VO2peak (ml/kg/min) (r = 0.419; p < 0.001; n = 126), (ii) a weak correlation with absolute VO2peak (ml/min) (r = 0.241; p = 0.008; n = 120), and (iii) a moderate correlation with the 6MWD (r = 0.440; p < 0.001; n = 85). The ONCORE equations obtained from the multivariate regression models allowed the estimation of VO2peak and 6MWD (r2 = 0.390; r2 = 0.261, respectively) based on the 30STS test, and its stratification into tertiles (low, moderate, and high). Conclusion The 30STS test was found to be a useful tool to estimate VO2peak and/or 6MWD in women with early-stage breast cancer. Its use may facilitate the assessment and stratification of functional capacity in this population for the implementation of therapeutic exercise programs if cardiopulmonary exercise testing (CPET) or 6MWT are not available. Trial registration ClinicalTrials.gov Identifier: NCT03964142. Registered on 28 May 2019. Retrospectively registered. https://clinicaltrials.gov/ct2/show/NCT03964142

Reliability and validity of clinical tests of cardiorespiratory fitness: A systematic review and meta-analysis

“…Seventy participants completing the 1MSTS with a moderate to strong correlation with CRF. The single papers were contrasting in their correlation with GXT, such as that of Guo et al (130)(RDST) demonstrated the RDST has good validity (0.82) using the author’s predictive model, however Diaz-Balboa’s (135) paper (30STST) demonstrated poor to moderate correlation – perhaps highlighting squat tests’ perceived limitations of relying more heavily on patients functional status, and reliance on HR recovery (130, 135).…”

Keep calm and keep rowing: the psychophysical effects of dragon boat program in breast cancer survivors

“…The results of each test were then compared with the expected distance. The ONCORE equation was instead used to estimate VO2peak using the 30CST repetitions and body mass as per Díaz‑Balboa [ 37 ].…”

Case–control study of the correlation between the five times sit to stand and 6-min walk distance in patients with pancreatic cancer

“…In healthy adults, 6 MWD has been reported to correlate significantly with orthostatic sitting, indicating that the sit-to-stand test (STS) may be a quick surrogate measure of physical and functional capacity. Furthermore, a significant correlation between 6MWD and STS has been shown in patients with pulmonary disease [19] and breast cancer [20].…”

“…In a recent systematic review, FTSTS has been proven to be highly reliable in both healthy adults and those with pathologies [17]. Associations between 6 MWD and orthostatic testing have been reported in healthy adults [18] and in patients with pulmonary disease [19] and cancer [20]. In healthy adults, 6 MWD has been reported to correlate significantly with orthostatic sitting, indicating that the sit-to-stand test (STS) may be a quick surrogate measure of physical and functional capacity.…”