Thoracic Aortic Mural Thrombus, Right Ventricular Clot and Pulmonary Embolism in a Patient With COVID-19 Pneumonia

Masana, Marc; Martínez, Laura Martínez; Gil, Miquel; Bueno, Gonzalo; Llagostera, Secundino

doi:10.1177/1538574420966106

Cited by 11 publications

(8 citation statements)

References 23 publications

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“…A total of 55 patients from the database research and 1 patient from our facility were included. 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 Of the included studies, 12 were case series and 26 were case reports. Essential characteristics of the included patients are outlined in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

Aortic Thrombosis following COVID-19: A Systematic Review

Petrov¹,

Romera²,

Wilbring³

et al. 2022

Thorac Cardiovasc Surg

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Background Arterial and venous thromboses associated with the coronavirus disease 2019 (COVID-19) have been well described. These events are caused by a hypercoagulable state due to endotheliopathy and infection-driven coagulopathy. There has been an ever-increasing number of documented cases of aortic thrombosis (AoT) in COVID-19 patients. We conducted a systematic review of current scientific literature to identify and consolidate evidence of AoT in COVID-19 patients. Methods A systematic review of literature was conducted between March 15, 2020, and May 1, 2021, on PubMed and Cochrane databases. Additionally, a case from our facility was included. Results A total of 38 studies (12 case series and 26 case reports) and a case from our facility describing AoT in 56 COVID-19 patients were included. Patients were aged 64.8 ± 10.5 years, were predominantly male (75%), and had several comorbidities. AoT was symptomatic in 82,14% of patients; however, when D dimers were reported, they were significantly elevated even in otherwise asymptomatic patients. Most patients had no previous history of aortic disease. Thrombosis was described in all parts of the aorta, with several cases reporting multiple locations. The median reported time until development of AoT was 10 days. Peripheral thrombosis occurred in 73.21% of cases, most commonly causing lower limb ischemia. Mortality rate was 30.4%. Conclusions AoT can occur with no clinical symptoms or as a primary symptom in otherwise asymptomatic COVID-19 patients. D dimers are a highly sensitive diagnostic tool. Diagnosis of this condition prior to development of complications could be instrumental in saving many lives.

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Section: Resultsmentioning

confidence: 99%

Aortic Thrombosis following COVID-19: A Systematic Review

Petrov¹,

Romera²,

Wilbring³

et al. 2022

Thorac Cardiovasc Surg

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“…The systematic review revealed thirty articles (17 case reports/series, 9 letters-to-journal-editors, 3 brief clinical imaging reports, and 1 retrospective study) detailing 52 SARS-CoV-2-positive patients with acute aortoiliac arterial thrombosis 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 . The available information from these cases were compiled and analyzed in addition to our institution's 7 cases.…”

Section: Resultsmentioning

confidence: 99%

Management of acute aortoiliac arterial thrombosis in patients with the novel coronavirus disease 2019: A case series and systematic review of the literature

Tohmasi

Kabutey

Maithel

et al. 2022

Annals of Vascular Surgery - Brief Reports and Innovations

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“…Since the beginning of the pandemic, most reports on thrombotic complications have focused on the problem of deep vein thrombosis and pulmonary embolism [ 19 , 20 , 21 ]. Although thrombus formation within the right atrium, right ventricle can lead to consecutive pulmonary embolism, this issue is under-reported in the scientific literature and clinical guidelines [ 22 , 23 , 24 , 25 ]. There are also few data on aortic thrombosis in COVID-19 and its combination with venous thrombosis [ 24 , 26 , 27 , 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Spectrum of Thrombotic Complications in Fatal Cases of COVID-19: Focus on Pulmonary Artery Thrombosis In Situ

Babkina

Yadgarov

Волков

et al. 2023

Viruses

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COVID-19-related thrombosis affects the venous and arterial systems. Data from 156 autopsies of COVID-19 patients were retrospectively analyzed to investigate the pattern of thrombotic complications and factors associated with pulmonary artery thrombosis and thromboembolism. Thrombotic complications were observed in a significant proportion (n = 68, 44%), with pulmonary artery thrombosis the most frequently identified thrombotic event (42, 27%). Multivariate analysis revealed that the length of hospital stay (OR 1.1, p = 0.004), neutrophil infiltration in the alveolar spaces (OR 3.6, p = 0.002), and the absence of hyaline membranes (OR 0.1, p = 0.01) were associated with thrombotic complications. Neutrophil infiltration in the alveolar spaces (OR 8, p < 0.001) and the absence of hyaline membranes (OR 0.1, p = 0.003) were also independent predictors of pulmonary artery thrombosis. The association of pulmonary artery thrombosis with an absence of hyaline membranes suggests it occurs later in the course of COVID-19 infection. As neutrophil infiltration in the alveolar spaces may indicate bacterial infection, our studies suggest the consideration of bacterial infections in these critically ill patients.

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Thoracic Aortic Mural Thrombus, Right Ventricular Clot and Pulmonary Embolism in a Patient With COVID-19 Pneumonia

Cited by 11 publications

References 23 publications

Aortic Thrombosis following COVID-19: A Systematic Review

Aortic Thrombosis following COVID-19: A Systematic Review

Management of acute aortoiliac arterial thrombosis in patients with the novel coronavirus disease 2019: A case series and systematic review of the literature

Spectrum of Thrombotic Complications in Fatal Cases of COVID-19: Focus on Pulmonary Artery Thrombosis In Situ

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