Thread integrated smart-phone imaging facilitates early turning point colorimetric assay for microbes

Prabhu, Anusha; Nandagopal, M. S. Giri; Yegneswaran, Prakash Peralam; Prabhu, V.K.; Verma, Ujjwal; Mani, Naresh Kumar

doi:10.1039/d0ra05190j

Cited by 29 publications

(8 citation statements)

References 60 publications

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“…The capability of nascent textile-based electrophoretic platforms presented here could be further extended by integrating the system with smartphones and handheld or textile-based batteries, a roadmap towards wearable sensors down the track. 37,38…”

Section: Methodsmentioning

confidence: 99%

Tuning the electrophoretic separations on a surface-accessible and flexible fibre-based microfluidic devices

et al. 2023

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Section: Methodsmentioning

confidence: 99%

Tuning the electrophoretic separations on a surface-accessible and flexible fibre-based microfluidic devices

et al. 2023

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“…In resource-constrained settings, distance-based nucleic acid assays using microfluidic paper-based analytical devices (μPAD) and other cellulose-based assays [60][61][62][63][64][65][66] offer great potential for the rapid and early diagnosis of diseases and detecting analytes. These devices measure the distance as a digital readout to quantify the concentration of nucleic acids.…”

Section: Distance-based Assaymentioning

confidence: 99%

DNA compaction enhances the sensitivity of fluorescence-based nucleic acid assays: a game changer in point of care sensors?

Sudarsan

Prabhu

Prasad

et al. 2023

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“…The detection was based on the byproducts released by the pathogens as a result of the metabolic breakdown of the different sugars in the media in question. This method was highly scalable and could potentially differentiate between different attacking pathogens [69] (Table 1).…”

Section: Colorimetric Detectionmentioning

confidence: 99%

Paper and thread as media for the frugal detection of urinary tract infections (UTIs)

et al. 2021

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Urinary tract infections (UTIs) make up a significant proportion of the global burden of disease in vulnerable groups and tend to substantially impair the quality of life of those affected, making timely detection of UTIs a priority for public health. However, economic and societal barriers drastically reduce accessibility of traditional lab-based testing methods for critical patient groups in low-resource areas, negatively affecting their overall healthcare outcomes. As a result, cellulose-based materials such as paper and thread have garnered significant interest among researchers as substrates for so-called frugal analytical devices which leverage the material’s portability and adaptability for facile and reproducible diagnoses of UTIs. Although the field may be only in its infancy, strategies aimed at commercial penetration can appreciably increase access to more healthcare options for at-risk people. In this review, we catalogue recent advances in devices that use cellulose-based materials as the primary housing or medium for UTI detection and chart out trends in the field. We also explore different modalities employed for detection, with particular emphasis on their ability to be ported onto discreet casings such as sanitary products. Graphical abstract

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Thread integrated smart-phone imaging facilitates early turning point colorimetric assay for microbes

Abstract: A proof-of-concept unifying thread devices and smart-phone imaging for low-cost microbial detection based on simple colour change.

Cited by 29 publications

References 60 publications

Tuning the electrophoretic separations on a surface-accessible and flexible fibre-based microfluidic devices

Tuning the electrophoretic separations on a surface-accessible and flexible fibre-based microfluidic devices

DNA compaction enhances the sensitivity of fluorescence-based nucleic acid assays: a game changer in point of care sensors?

Paper and thread as media for the frugal detection of urinary tract infections (UTIs)

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