Threat and sustainable technological solution for antineoplastic drugs pollution: Review on a persisting global issue

Yadav, Ankush; Rene, Eldon R.; Mandal, Mrinal Kanti; Dubey, Kashyap Kumar

doi:10.1016/j.chemosphere.2020.128285

Cited by 57 publications

(27 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The abuse of drugs has increased in some regions and the drugs enter the water environment through animal and human excretion, improper human medical waste operations. Due to the stability of certain drugs, the ecotoxicity of metabolites, the accumulation and amplification effect in the food chain and the low removal efficiency of wastewater treatment plants, drugs discharged into the environment will have adverse effects on aquatic organisms 6,13,14 . Tyrosine kinase inhibitors inhibit tumor growth by blocking intracellular protein phosphorylation signals 15 .…”

Section: Discussionmentioning

confidence: 99%

“…Due to the stability of certain drugs, the ecotoxicity of metabolites, the accumulation and amplification effect in the food chain and the low removal efficiency of wastewater treatment plants, drugs discharged into the environment will have adverse effects on aquatic organisms. 6,13,14 Tyrosine kinase inhibitors inhibit tumor growth by blocking intracellular protein phosphorylation signals. 15 Topoisomerase inhibitor irinotecan (IRI) can be detected in hospital wastewater, but it can be effectively removed by wastewater treatment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation

Liu

Huang

Wan

et al. 2022

Environmental Toxicology

View full text Add to dashboard Cite

Due to an increasing number of abused drugs dumped into the wastewater, more and more drugs are detected in the water environment, which may affect the survival of aquatic organisms. Lenvatinib is a multi-targeted tyrosine kinase inhibitor, and is clinically used to treat differentiated thyroid cancer, renal epithelial cell carcinoma and liver cancer. However, there are few reports on the effects of lenvatinib in embryos development. In this study, zebrafish embryos were used to evaluate the effect of lenvatinib on cardiovascular development. Well-developed zebrafish embryos were selected at 6 h post fertilization (hpf) and exposed to 0.05 mg/L, 0.1 mg/L and 0.2 mg/L lenvatinib up to 72 hpf. The processed embryos demonstrated cardiac edema, decreased heart rate, prolonged SV-BA distance, inhibited angiogenesis, and blocked blood circulation. Lenvatinib caused cardiac defects in the whole stage of cardiac development and increased the apoptosis of cardiomyocyte.Oxidative stress in the processed embryos was accumulated and inhibiting oxidative stress could rescue cardiac defects induced by lenvatinib. Additionally, we found that lenvatinib downregulated Notch signaling, and the activation of Notch signaling could rescue cardiac developmental defects and downregulate oxidative stress level induced by lenvatinib. Our results suggested that lenvatinib might induce cardiac developmental toxicity through inducing Notch mediated-oxidative stress generation, raising concerns about the harm of exposure to lenvatinib in aquatic organisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation

Liu

Huang

Wan

et al. 2022

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…Different international agencies have developed protocols for the handling and storing of pharmaceuticals to reduce their harmful effect on the environment ( Bernabeu-Martínez et al, 2018 ). One of the main concerns is that these drugs may suffer biomagnification ( Yadav et al, 2021 ).…”

Section: Common Pharmaceuticals Detected In Water (Surface and Ground...mentioning

confidence: 99%

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

et al. 2022

View full text Add to dashboard Cite

The presence of emerging contaminants in the environment, such as pharmaceuticals, is a growing global concern. The excessive use of medication globally, together with the recalcitrance of pharmaceuticals in traditional wastewater treatment systems, has caused these compounds to present a severe environmental problem. In recent years, the increase in their availability, access and use of drugs has caused concentrations in water bodies to rise substantially. Considered as emerging contaminants, pharmaceuticals represent a challenge in the field of environmental remediation; therefore, alternative add-on systems for traditional wastewater treatment plants are continuously being developed to mitigate their impact and reduce their effects on the environment and human health. In this review, we describe the current status and impact of pharmaceutical compounds as emerging contaminants, focusing on their presence in water bodies, and analyzing the development of bioremediation systems, especially mycoremediation, for the removal of these pharmaceutical compounds with a special focus on fungal technologies.

show abstract

“…Several approaches have been adapted to decontaminate polluted aquatic environments from HMs and organic pollutants (Ajiboye et al 2021) using techniques such as biochar , nano zero valent iron (Sliječpević et al 2021), and clays (Elshazly et al 2019). Other pollutants may cause serious threats to human health and ecosystems when they reach aquatic environments, including nanoparticles (Turan et al 2019;Souza et al 2021), antibiotics Xu et al 2021), microplastics (Ma et al 2020;Tang et al 2020;Pan et al 2021;Wang et al 2021), bisphenols Šauer et al 2021), retinoic acids (Yeung et al 2020), perfluoroalkylated acids (Groffen et al 2021), heavy metals (Aitta et al 2019;Karaouzas et al 2021), personal care products Lu et al 2021), antineoplastic agents (Yadav et al 2021) and COVID-19 (Kumar et al 2020a;Steffan et al 2020;Lachrich et al 2021). On the other hand, during lockdowns to combat COVID-19, the quality of surface water (Yunus et al 2020) and air (Guatam, 2020) are expected to improve.…”

Section: Aquatic Environments and Their Pollutionmentioning

confidence: 99%

New Pollution Challenges in Groundwater and Wastewater Due to COVID-19

El-Ramady

Eid

Brevik

2020

Journal of Sustainable Agricultural Sciences

View full text Add to dashboard Cite

Threat and sustainable technological solution for antineoplastic drugs pollution: Review on a persisting global issue

Cited by 57 publications

References 125 publications

Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation

Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

New Pollution Challenges in Groundwater and Wastewater Due to COVID-19

Contact Info

Product

Resources

About