Three alkaloids and one polyketide from Aspergillus cristatus harbored in Pinellia ternate tubers

Wang, Mingling; Chen, Rong; Sun, Fu–Juan; Cao, Peng-Ran; Chen, Xingru; Yang, Ming‐Hua

doi:10.1016/j.tetlet.2021.152914

Cited by 6 publications

(7 citation statements)

References 24 publications

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“…Aspergilline A (163) is the first example of a bicyclo[2.2.2] diazaoctane indole alkaloid where the diketopiperazine structure is constructed from tryp-tophan and alanine. Aspergillone A (163) exhibited average antibacterial activities against B. subtilis and S. aureus, with MIC 50 values of 8.5 and 32.2 µg/mL, respectively [85]. A new quinolone derivative, (22S)-aniduquinolone A (164) and its known isomer (22R)aniduquinolone A (165, Figure 10) were purified from the endophytic fungus Aspergillus versicolor strain Eich.5.2.2 from the petals of flowers of Eichhornia crassipes.…”

Section: Aspergillusmentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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Section: Aspergillusmentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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“…The antibacterial activity of the minimum inhibitory concentration (MIC) of 96 well plates was determined by the continuous dilution method [ 20 ]. Compounds 1 – 7 were dissolved in dimethyl sulfoxide (DMSO) to prepare 10 mg/ml.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Secondary metabolites of endophytic fungi of P. ternata have been shown to have outstanding antibacterial activity [ 18 – 20 ]. For instance, aspergillone A from endophytic Aspergillus cristatus of P. ternata exhibited remarkable antibacterial effects [ 20 ]. However, as far as we know, the diversity and antibacterial activity of its endophytic fungi have not been systematically studied.…”

Section: Introductionmentioning

confidence: 99%

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Diversity, antibacterial and phytotoxic activities of culturable endophytic fungi from Pinellia pedatisecta and Pinellia ternata

et al. 2023

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Background Endophytic fungi of medicinal plants, as special microorganisms, are important sources of antibacterial compounds. However, the diversity and antibacterial activity of endophytic fungi from Pinellia Tenore have not been systematically studied. Results A total of 77 fungi were isolated from roots, stems, leaves, and tubers of Pinellia ternata and P. pedatisecta. All fungi were belonged to five classes and twenty-five different genera. Biological activities tests indicated that 21 extracts of endophytic fungi exhibited antibacterial activities against at least one of the tested bacteria, and 22 fermentation broth of endophytic fungi showed strong phytotoxic activity against Echinochloa crusgalli with the inhibition rate of 100%. Furthermore, four compounds, including alternariol monomethyl ether (1), alternariol (2), dehydroaltenusin (3) and altertoxin II (4), and three compounds, including terreic acid (5), terremutin (6), citrinin (7), were isolated from Alternaria angustiovoidea PT09 of P. ternata and Aspergillus floccosus PP39 of P. pedatisecta, respectively. Compound 5 exhibited strong antibacterial activities against Escherichia coli, Micrococcus tetragenus, Staphylococcus aureus, and Pseudomonas syringae pv. actinidiae with the inhibition zone diameter (IZD) of 36.0, 31.0, 33.7, 40.2 mm and minimum inhibitory concentration (MIC) values of 1.56, 3.13, 1.56, 1.56 μg/mL respectively, which were better than or equal to those of positive gentamicin sulfate. The metabolite 7 also exhibited strong antibacterial activity against P. syringae pv. actinidiae with the IZD of 26.0 mm and MIC value of 6.25 μg/mL. In addition, the compound 7 had potent phytotoxic activity against E. crusgalli with the inhibition rate of 73.4% at the concentration of 100 μg/mL. Conclusions Hence, this study showed that endophytic fungi of P. ternata and P. pedatisecta held promise for the development of new antibiotic and herbicide resources.

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“…Alkaloids are one of the most important medicinal compounds in P. ternata, among which ephedrine is the main ingredient that belongs to phenylpropylamino alkaloids. Studies have shown that ephedrine plays an important role in clinical treatment, such as bronchial asthma, nasal mucosal congestion and nasal congestion [41,42]. Therefore, it is desirable to improve the quality of P. ternata by increasing the content of ephedrine.…”

Section: Lysine Crotonylation Contributes To the Biosynthesis Of Ephe...mentioning

confidence: 99%

Large-scale analysis of protein crotonylation reveals its diverse functions in Pinellia ternata

Guo

Han

et al. 2022

BMC Plant Biol

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Background Pinellia ternata is an important traditional medicine in China, and its growth is regulated by the transcriptome or proteome. Lysine crotonylation, a newly identified and important type of posttranslational modification, plays a key role in many aspects of cell metabolism. However, little is known about its functions in Pinellia ternata. Results In this study, we generated a global crotonylome analysis of Pinellia ternata and examined its overlap with lysine succinylation. A total of 2106 crotonylated sites matched on 1006 proteins overlapping in three independent tests were identified, and we found three specific amino acids surrounding crotonylation sites in Pinellia ternata: KcrF, K***Y**Kcr and Kcr****R. Gene Ontology (GO) and KEGG pathway enrichment analyses showed that two crucial alkaloid biosynthesis-related enzymes and many stress-related proteins were also highly crotonylated. Furthermore, several enzymes participating in carbohydrate metabolism pathways were found to exhibit both lysine crotonylation and succinylation modifications. Conclusions These results indicate that lysine crotonylation performs important functions in many biological processes in Pinellia ternata, especially in the biosynthesis of alkaloids, and some metabolic pathways are simultaneously regulated by lysine crotonylation and succinylation.

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Three alkaloids and one polyketide from Aspergillus cristatus harbored in Pinellia ternate tubers

Cited by 6 publications

References 24 publications

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Diversity, antibacterial and phytotoxic activities of culturable endophytic fungi from Pinellia pedatisecta and Pinellia ternata

Large-scale analysis of protein crotonylation reveals its diverse functions in Pinellia ternata

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