Three Coagulation Related Mutations and Increased Risk of Myoma in Women of Fars Province

Abstract

Background: Myoma is one of the most common benign tumor in the women's genital tract and causing some implications such as miscarriages, anemia or even infertility. Since tumorigenesis is associated with a hypercoagulant state, we investigate the role of coagulation related variations in methylene-tetra hydrofolate reductase (MTHFR) and endothelial protein C receptor (EPCR) genes in patients with uterine myoma. Methods: In this case-control study, genotyping was performed for rs867186, rs1801131 and rs1801133 by amplification-refractory mutation system-polymerase chain reaction (ARMS-PCR) method in 73 patients with myoma and 73 healthy women. Data was analyzed