Three-component non-ionic oil-in-water microemulsions using polyoxyethylene ether surfactants

Malcolmson, Carole; Lawrence, M. Jayne

doi:10.1016/0927-7765(94)01160-7

Cited by 69 publications

(40 citation statements)

References 33 publications

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“…Systems were permitted to age overnight at 27-C under stirring before additional experiments were carried out. Phase diagrams of the three microemulsion systems in the absence of model steroids (not shown) were consistent with those published by Malcolmson and Lawrence (13). The choice of 27-C as the temperature of the study was dictated by the capability of the NMR spectrometer, outlined below.…”

Section: Formulationsmentioning

confidence: 79%

Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations

Land

Bummer

2006

Pharm Res

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In systems nearly saturated with drug, the microemulsion formulation leads to a greatly enhanced rate of steady-state mass transport while in systems with drug loading far from saturation, the microemulsion formulation appears to have a minimal ability to promote mass transport. The aqueous boundary layer diffusion model was successful in fitting progesterone results but was not successful for estradiol.

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Section: Formulationsmentioning

confidence: 79%

Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations

Land

Bummer

2006

Pharm Res

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“…Microemulsions are frequently defined as clear, isotropic, thermodynamically stable dispersions of two immiscible liquids brought about by the presence of a suitable surfactant, usually in conjunction with a cosurfactant (typically a short-chain alcohol) [30]. Microemulsions used in MEEKC are nanometer-sized oil droplets dispersed in an aqueous buffer.…”

Section: Introductionmentioning

confidence: 99%

Dual opposite injection electrokinetic chromatography: Nonionic microemulsion pseudostationary phase and novel approach to electrokinetic sampling bias

Zhou

Foley

2004

Electrophoresis

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Dual opposite injection capillary electrophoresis (DOI-CE) is a family of CE techniques in which the sample is introduced into both ends of the capillary. For the analysis of compounds with widely varying pKa values using a voltage-driven separation scheme, DOI-CE is superior to conventional CE with sample introduction at only one end of the capillary due to DOI-CE's broader elution window. To enhance the DOI-CE separation, a running buffer with a microemulsion system was developed. Since DOI-CE works best under conditions of low electroosmotic flow (EOF), the suppression of EOF via the addition of a multiply charged cation (e.g., Zn2+) to the buffer was investigated, and was found to suppress the EOF effectively at moderate concentrations (2.5-10 mM). Three different dual opposite injection modes were studied: simultaneous electrokinetic injection, sequential electrokinetic injection, and sequential hydrodynamic injection. The injection bias in the first two electrokinetic injection modes was compared with the sequential hydrodynamic injection. Corrections in the bias of the electrokinetic injections were discussed, and an improved approach was suggested. Finally, the effect of the relative concentration of the multiply charged cation in the sample plug and running buffer on the peak shape of co-electroosmotic and counter-electroosmotic ions was examined, and found to be much more influential on the latter.

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“…Brij 97, oleyl polyoxyethylene (10) ether, is a pharmaceutically accepted surfactant. For years, microemulsions formed by Brij 97 have been studied as drug delivery systems [1][2][3][4]. However, there are only limited investigations on the liquid crystals for such long-chain surfactants [5][6][7], though lamellar and hexagonal liquid crystals of this surfactant were found 20 years ago [8].…”

Section: Introductionmentioning

confidence: 99%

Microstructure and rheological properties of liquid crystallines formed in Brij 97/water/IPM system

Wang

Diao

Liu

et al. 2006

Journal of Colloid and Interface Science

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Three-component non-ionic oil-in-water microemulsions using polyoxyethylene ether surfactants

Cited by 69 publications

References 33 publications

Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations

Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations

Dual opposite injection electrokinetic chromatography: Nonionic microemulsion pseudostationary phase and novel approach to electrokinetic sampling bias

Microstructure and rheological properties of liquid crystallines formed in Brij 97/water/IPM system

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