Three-Dimensional 13C-Spectroscopic Imaging in the Isolated Infarcted Rat Heart

Weidensteiner, Claudia; Lanz, Titus; Horn, Michael; Neubauer, Stefan; Haase, Axel; Kienlin, Markus von

doi:10.1006/jmre.1999.1984

Cited by 8 publications

(1 citation statement)

References 20 publications

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“…Two slices were acquired by using 1 H‐MRSI, the first in the bihippocampal plane, and the second in the bicommissural plane (AC – PC + 8 mm) with an in‐house–designed acquisition‐weighted, hamming shape, 2D‐SE pulse sequence (TE/TR = 136 ms/1,500 ms, 15‐mm slice thickness, FOV = 240 mm, 21 × 21 encoding steps leading to 524 free induction decays acquired in 12 min (20,21). The spatial resolution was defined as the width of the spatial response function at 64% of maximum (22), leading to a spatial resolution of 5.7 ml and a cylindrical shape–like voxel. All radiofrequency pulses were optimized and generated by using the Matpulse software (23).…”

Section: Methodsmentioning

confidence: 99%

Metabolic and Electrophysiological Alterations in Subtypes of Temporal Lobe Epilepsy: A Combined Proton Magnetic Resonance Spectroscopic Imaging and Depth Electrodes Study

et al. 2002

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Summary:Purpose: This study compared the metabolic regional alterations, characterized by proton magnetic spectroscopic imaging ( 1 H-MRSI), with electrophysiological abnormalities recorded by using depth electrodes and with structural lesions, in patients with several subtypes of temporal lobe epilepsy (TLE).Methods: Twenty-five subjects were investigated, including 15 controls and 10 patients with drug-resistant unilateral TLE, nine of whom had structural abnormalities identified by MRI. All patients underwent noninvasive presurgical evaluation and then stereoelectroencephalography (SEEG). We performed an original metabolic exploration combining two 1 H-MRS imaging acquisitions associated with two single-voxel acquisitions (temporal poles) to map the most informative regions of interest (ROIs) including mesial and neocortical localizations. The N-acetyl aspartate/(choline+creatine) ratio was chosen as a metabolic index. SEEG analysis allowed the classification of each ROI as electrically normal or abnormal (i.e., involved in ictal and/or interictal discharges). Groups were compared by using a nonparametric Mann-Whitney U test.Results: N-Acetyl aspartate/(choline+creatine) was significantly lower in all regions involved in SEEG electrophysiological epileptic abnormalities than in controls (p < 0.05). In contrast, the regions without any electrophysiological abnormalities were not metabolically different from those in controls (p > 0.05) except in one ROI. No differences between the metabolic profiles of epileptogenic and irritative zones were found. The metabolic alterations included, but also extended beyond, the lesions. The presence of metabolic abnormalities in mesial structures was not specific for the mesial subtype and generally extended outside the mesial structures.Conclusions: These results indicate that metabolic abnormalities are linked to ictal and interictal epileptiform activities rather than to structural alterations in TLE.

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Section: Methodsmentioning

confidence: 99%