Three-Dimensional Cardiac Electrical Imaging From Intracavity Recordings

He, Bin; Liu, Chenguang; Zhang, Yingchun

doi:10.1109/tbme.2007.891932

Cited by 15 publications

(13 citation statements)

References 34 publications

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“…Although successful in the treatment of simple arrhythmias originating in and around the pulmonary veins, these devices are poorly suited for treating complex arrhythmias, such as persistent atrial fibrillation (10)(11)(12)(13), that arise from various sites inside the left atrium. Other classes of devices have demonstrated the utility of spatiotemporal voltage mapping using various modes of operation, including noninvasive surface mapping designs (14,15), epicardial voltage-mapping "socks" (16)(17)(18)(19)(20), and endocardial contact and noncontact catheters, with densities approaching 64 electrodes (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). These solutions all exploit arrays of passive metal wirebased electrodes integrated on wearable vests and socks (14)(15)(16)(17)(18)(19)(20) or catheter systems (21)(22)(23)(24)(25)(26) for mapping of complex arrhythmias.…”

mentioning

confidence: 99%

Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

Kim

Ghaffari

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

221

167

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Curved surfaces, complex geometries, and time-dynamic deformations of the heart create challenges in establishing intimate, nonconstraining interfaces between cardiac structures and medical devices or surgical tools, particularly over large areas. We constructed large area designs for diagnostic and therapeutic stretchable sensor and actuator webs that conformally wrap the epicardium, establishing robust contact without sutures, mechanical fixtures, tapes, or surgical adhesives. These multifunctional web devices exploit open, mesh layouts and mount on thin, bio-resorbable sheets of silk to facilitate handling in a way that yields, after dissolution, exceptionally low mechanical moduli and thicknesses. In vivo studies in rabbit and pig animal models demonstrate the effectiveness of these device webs for measuring and spatially mapping temperature, electrophysiological signals, strain, and physical contact in sheet and balloon-based systems that also have the potential to deliver energy to perform localized tissue ablation.flexible electronics | semiconductor nanomaterials | stretchable electronics | implantable biomedical devices | cardiac electrophysiology C ardiac arrhythmias occur in all component structures and 3D regions of the heart, resulting in significant challenges in diagnosis and treatment of precise anatomic targets (1). Many common arrhythmias, including atrial fibrillation and ventricular tachycardia, originate in endocardial substrates and then propagate in the transverse direction to affect epicardial regions (1, 2). Characterizing arrhythmogenic activity at specific regions of the heart is thus critical for establishing the basis for definitive therapies such as cardiac ablation (3). Advanced tools that offer sufficient spatial resolution (<1 mm) and intimate mechanical coupling with myocardial tissue, but without undue constraints on natural motions, would therefore be of great clinical importance (4-6). To date, cardiac ablation procedures have largely relied on point ablation catheters deployed in the endocardial space (1, 5, 7-9). Although successful in the treatment of simple arrhythmias originating in and around the pulmonary veins, these devices are poorly suited for treating complex arrhythmias, such as persistent atrial fibrillation (10-13), that arise from various sites inside the left atrium. Other classes of devices have demonstrated the utility of spatiotemporal voltage mapping using various modes of operation, including noninvasive surface mapping designs (14, 15), epicardial voltage-mapping "socks" (16-20), and endocardial contact and noncontact catheters, with densities approaching 64 electrodes (21-31). These solutions all exploit arrays of passive metal wirebased electrodes integrated on wearable vests and socks (14-20) or catheter systems (21-26) for mapping of complex arrhythmias. Building such mesh structures requires manual assembly and is only possible because the individual wires are millimeter scale in diameter and thus sufficiently large to be threaded to form a mesh.Fo...

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mentioning

confidence: 99%

Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

Kim

Ghaffari

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

221

167

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“…Thus the equivalent current densities at thousands of uniformly distributed locations inside the myocardium were calculated representing the ventricular activities during activation. Based on the bidomain theory, the field potential ϕ can be calculated from those current sources employing the Poisson’s equation [19],

\nabla \cdot [(σ_{i} + σ_{e}) \nabla ϕ] = \nabla \cdot j

where σ e is the extracellular conductivity tensor. Eq.…”

Section: Methodsmentioning

confidence: 99%

“…Based on the forward modeling described above, a heart-model-based estimation algorithm was optimized to derive the cardiac activation sequence from the raw ICPMs recorded by the MEA in the NCM system [19]. The parameters of the numerical heart model were initialized by using a preliminary classification system [23], and the corresponding ICPM was calculated by using FEM.…”

Section: Methodsmentioning

confidence: 99%

“…The heart model’s parameters were then iteratively adjusted in an attempt to minimize the dissimilarity between the measured and the heart-model-generated ICPMs. The details of the algorithm with which the locations of the initiation sites and the activation sequences were estimated were described in [19]. …”

Section: Methodsmentioning

confidence: 99%

“…In order to address this issue, we have proposed the three-dimensional cardiac electrical imaging (3DCEI) approach, a novel functional imaging method using intracavitary recordings, to reconstruct electrical activation in 3D myocardium from endocardium to epicardium [19]. In the present study, we report for the first time experimental data to image 3D activation sequence from intracavitary recordings.…”

Section: Introductionmentioning

confidence: 99%

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Three-Dimensional Imaging of Ventricular Activation and Electrograms From Intracavitary Recordings

Liu

Iaizzo

2011

IEEE Trans. Biomed. Eng.

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Three-dimensional mapping of the ventricular activation is of importance to better understand the mechanisms and facilitate management of ventricular arrhythmia. The goal of the present study was to develop and evaluate a three-dimensional cardiac electrical imaging (3DCEI) approach for imaging myocardial electrical activation from the intracavitary electrograms and heart-torso geometry information over the 3-dimensional (3D) volume of the heart. The 3DCEI was evaluated in a swine model undergoing intracavitary non-contact mapping (NCM). Each animal's preoperative MRI data were acquired to construct the heart-torso model. NCM was performed with the Ensite ® 3000 system during acute ventricular pacing. Subsequent 3DCEI analyses were performed on the measured intracavitary electrograms. The estimated initial sites (ISs) were compared to the precise pacing locations, and the estimated activation sequences (ASs) and electrograms (EGs) were compared to those recorded by the NCM system over the endocardial surface. In total, 6 ventricular sites from 2 pigs were paced. The averaged localization error of IS was 6.7 ± 2.6 mm. The endocardial ASs and EGs as a subset of the estimated 3-dimensional solutions were consistent with those reconstructed from the NCM system. The present results demonstrate that the intracavitary-recording-based 3DCEI approach can well localize the sites of initiation and can obtain physiologically reasonable activation sequences as well as electrograms in an in vivo setting; under control/paced conditions. The present study suggests the feasibility of tomographic imaging of 3D ventricular activation and 3D electrograms from intracavitary recordings.

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Cardiac Electrophysiological Imaging: Solving the Inverse Problem of Electrocardiography

Liu²

2010

Cardiac Electrophysiology Methods and Models

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Three-Dimensional Cardiac Electrical Imaging From Intracavity Recordings

Cited by 15 publications

References 34 publications

Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

Three-Dimensional Imaging of Ventricular Activation and Electrograms From Intracavitary Recordings

Cardiac Electrophysiological Imaging: Solving the Inverse Problem of Electrocardiography

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