Three-dimensional dose accumulation in pseudo-split-field IMRT and brachytherapy for locally advanced cervical cancer

Accumulation of rectum dose‐volume metrics for prostate external beam radiotherapy combined with brachytherapy: Evaluating deformably registered dose distribution addition using parameter‐based addition

“…This study improved upon these studies by including a larger sample size of 82 patients, applying deformable image registration and comparing parameter‐adding and distribution‐adding. The context of this study is also important as it should not be assumed the comparisons of parameter‐adding and distribution‐adding reported for non‐prostate cancer treatments set a precedent for prostate cancer treatments, as the contouring, registration, anatomy, protocol and treatment circumstances are different and require verification.…”

“…Given this is the first study to compare the choice of methods for combined EBRT/HDR‐BT prostate cancer treatments, we encourage more centres to undertake more prostate cancer studies to assess the accuracy of dose accumulation using similar methods to those applied for combined EBRT/HDR‐BT cervical cancer treatment . Software developers and treatment‐planning vendors have the opportunity to contribute considerably to this advanced accumulation‐based EBRT/HDR‐BT treatment by customising registrations for this context.…”

“…Given this is the first study to compare the choice of methods for combined EBRT/HDR-BT prostate cancer treatments, we encourage more centres to undertake more prostate cancer studies to assess the accuracy of dose accumulation using similar methods to those applied for combined EBRT/HDR-BT cervical cancer treatment. 2,7,11 Software developers and treatment-planning vendors have the opportunity to contribute considerably to this advanced accumulation-based EBRT/HDR-BT treatment by customising registrations for this context. Studies at other institutions regarding the choice of methods for prostate cancer treatments would be useful for assessing the influence of confounding factors on the discrepancies between the methods and reporting the comparisons for a variety of registration algorithms.…”

Dose-Volume Histogram Analysis in Point A-based Dose Prescription of High-dose-rate Brachytherapy for Cervical Carcinoma

“…According to a report by Macdonald et al 18 , a combination of pseudo-split-field IMRT and brachytherapy delivers a significantly higher dose to the primary tumor and lymph nodes compared to a four-field box plan or IMRT not using a split field. Sun et al 19 demonstrated the possibility of performing 2 Gy-per-fraction equivalent dose accumulation by combined split-field IMRT and brachytherapy. These findings support the next transition to using IMRT for cervical cancer.…”

Computerized triplet beam orientation optimization for MRI‐guided Co‐60 radiotherapy

“…The MRI-guided tri-Co-60 system uses a simpler radiation source and was able to gain early clinical access that is extremely valuable for accumulating knowledge about MRI-guided RT. [19][20][21][22][23][24][25][26][27][28] There are several known limitations with Co-60 sources, including lower energy and penetration, compared to the 6 MV and above x-ray energies used by a conventional linac and large source size (2 cm) compared to the linac source (∼2 mm). T V. Largest, smallest, and average values found for (FROST-CLN) dose differences for D max and D mean .…”