Three‐Dimensional Echocardiography in the Evaluation of Right Ventricular Global and Regional Systolic Function in Patients with Atrial Septal Defect before and after Percutaneous Closure

Kong, Dehong; Cheng, Leilei; Dong, Lili; Pan, Cuizhen; Yao, Haohua; Zhou, Daxin; Shu, Xianhong

doi:10.1111/echo.13134

Cited by 16 publications

(12 citation statements)

References 39 publications

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“…However, as CMR combines accurate volumetric assessment with accurate flow quantification and is moreover appealing for myocardial strain imaging, it is increasingly used to study the pathologic RV. Literature shows variable, often contradictory, results with regard to global RV systolic performance in ASD patients [22][23][24][25][26]. Our findings-indicative of impaired function-are in line with the work of Stephensen et al [27].…”

Section: Discussionsupporting

confidence: 89%

Assessment of long-term cardiac adaptation in adult patients with type II atrial septal defect

et al. 2020

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Section: Discussionsupporting

confidence: 89%

Assessment of long-term cardiac adaptation in adult patients with type II atrial septal defect

et al. 2020

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“…There was no change in the global RV systolic function but a high basal RV systolic function decreased after closure. Some patients had impaired diastolic function before closure of defect, which reversed to normal within 6 months after closure [ 15 ]. TAPSE is a standard RV parameter that gives quantitative information about RV function.…”

Section: Discussionmentioning

confidence: 99%

“…In our cohort, there was a significant increase in the LVEDV and GLS 6 months post-ASD closure. In contrast, it was previously published that circumferential strain was increased significantly 24 hours after ASD closure and might be used as an indicator of LV response to normalized loading conditions [ 14 , 15 ]. LVLS was not affected early after ASD closure may be due to later improvement after 6 months after closure [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Left and right ventricular speckle tracking study before and after percutaneous atrial septal defect closure in children

Agha¹,

Mohammed²,

Hassan³

et al. 2020

Journal of the Saudi Heart Association

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Objectives To analyze the acute and short-term deformation changes of both right (RV) and left (LV) ventricular wall before and after transcatheter closure of atrial septal defect (ASD) secundum in children. Outcome measures To determine the feasibility of tissue Doppler and myocardial deformation imaging for evaluating RV and LV functions in children undergoing transcatheter ASD closure. Patients and methods A prospective study was performed for 32 children with hemodynamic significant ASD secundum before and 6 months after percutaneous ASD closure in the Pediatric Cardiology Division of Specialized Pediatric Hospital, Cairo University. Speckle tracking echocardiography (STE) of LV and RV global analysis (longitudinal and circumferential strain) before and after ASD transcatheter closure was performed. Results The mean age of the patients was 6.01 ± 3.19 (range: 3–9) years with a female to male ratio of 1.3:1. There was an improvement in the RV and LV myocardial performance index (MPI) 6 months post-ASD closure (RVMPI = 0.46 ± 0.069 vs. 0.38 ± 0.05, p < 0.0001; LVMPI = 0.49 ± 0.12 vs. 0.38 ± 0.08, p < 0.0001, respectively). By 2D STE, there was a significant improvement in the RV global longitudinal strain (GLS) 6 months post-ASD closure (−20.17 ± 3.14% vs. −25.86 ± 5.02%, p < 0.0001). There was a significant increase in the LV end-diastolic volume (EDV) and LV end-systolic volume (ESV) using 4D STE after device closure (LVEDV = 32.96 ± 10.99 mL vs. 44.024 ± 14.9017 mL, p < 0.0001; LVESV = 15.16 ± 6.08 mL vs. 21.76 ± 8.34 mL, p < 0.0001, respectively). Additionally, there was a significant improvement in the LV GLS after device occlusion (−19.17 ± 3.67% vs. −22.36 ± 4.72%, p = 0.009) using 4D TomTec software. There was a significant decrease in the RVEDV (54.65 ± 10.05 mL vs. 15.73 ± 8.67 mL) and RV stroke volume (25.15 ± 6.36 vs. 20.06 ± 7.2) after device occlusion using 4D TomTec software. Conclusion By using 4D STE, the LV GLS was significantly improved; in contrast, by 2D STE, the RV volume overload decreased and the RV GLS was improved on short term after transcatheter ASD secundum closure in children.

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“…Following Starling's law of the heart, the increased preload results in high ventricular ejection function. e parameters of RV function such as RV ejection fraction, TAPSE, S, and RV FAC tend to be elevated in patients with ASD and are decreased after device closure [21][22][23]. e degree of RV ejection fraction depends on RV volume overload.…”

Section: Discussionmentioning

confidence: 99%

Impact of Right Ventricular Dilatation in Patients with Atrial Septal Defect

Nakayama

Takaya

Akagi

et al. 2020

Journal of Interventional Cardiology

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Objective. The aim of this study was to examine the relationship between right ventricular (RV) volume and exercise capacity in adult patients with atrial septal defect (ASD) and to determine the degree of RV dilatation for transcatheter ASD closure. Background. RV dilatation is an indication of transcatheter ASD closure; however, few studies have reported the clinical significance of RV dilatation. Methods. We enrolled 82 consecutive patients (mean age, 49 ± 18 years; female, 68%) who underwent cardiac magnetic resonance imaging and symptom-limited cardiopulmonary exercise test before ASD closure. The relationship between RV volume and peak oxygen uptake (VO2) was evaluated. Results. The mean RV end-diastolic volume index was 108 ± 27 ml/m2 (range, 46 to 180 ml/m2). The mean peak VO2 was 24 ± 7 ml/min/kg (range, 14 to 48 ml/min/kg), and the mean predicted peak VO2 was 90 ± 23%. There were significant negative relationships of RV end-diastolic volume index with peak VO2 (r = −0.28, p<0.01) and predicted peak VO2 (r = −0.29, p<0.01). The cutoff value of RV end-diastolic volume index <80% of predicted peak VO2 was 120 ml/m2, with the sensitivity of 49% and the specificity of 89%. Conclusions. There was a relationship between RV dilatation and exercise capacity in adult patients with ASD. RV end-diastolic volume index ≥120 ml/m2 was related to the reduction in peak VO2. This criterion of RV dilatation may be valuable for the indication of transcatheter ASD closure.

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Three‐Dimensional Echocardiography in the Evaluation of Right Ventricular Global and Regional Systolic Function in Patients with Atrial Septal Defect before and after Percutaneous Closure

Abstract: RV global and regional systolic functions are impaired in open and closed ASD. RT3DE-derived systolic function parameters are negatively correlated with RV after load. RT3DE has potential value in the evaluation of RV systolic function in patients with ASD.

Cited by 16 publications

References 39 publications

Assessment of long-term cardiac adaptation in adult patients with type II atrial septal defect

Assessment of long-term cardiac adaptation in adult patients with type II atrial septal defect

Left and right ventricular speckle tracking study before and after percutaneous atrial septal defect closure in children

Impact of Right Ventricular Dilatation in Patients with Atrial Septal Defect

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