Three-Dimensional Hierarchical Wrinkles on Polymer Films: From Chaotic to Ordered Antimicrobial Topographies

Nguyen, Duy H. K.; Bazaka, Olha; Bazaka, Kateryna; Crawford, Russell J.; Ivanova, Elena P.

doi:10.1016/j.tibtech.2019.12.004

Cited by 15 publications

(14 citation statements)

References 75 publications

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“…However, E. coli contact killing was also improved using wrinkled surfaces, demonstrating the potentiality of this strategy. Different polymeric supports have previously discussed this synergic behavior between surface composition and topography [ 16 ], showing results similar to the obtained but without the pH responsiveness capacity of the AAc-based wrinkled hydrogel film presented in this study. Finally, these results demonstrate an apparent antibacterial effect for all evaluated wrinkled samples, suggesting their application as coatings for clinical devices or biomedical applications.…”

Section: Resultssupporting

confidence: 89%

“…Thus, the formation and characterization of wrinkles are tailored by regulating the prestretch of adherend and optimizing adhesive ingredients synergistically. Furthermore, the topographic characteristics of the wrinkled patterns of different scales of length and amplitude in polymeric materials have been used to selectively control the adherence and proliferation of various cells [ 16 ]. These micro-nano structures allow the development of surfaces with effective antibacterial activity by direct contact (bactericidal) or preventing bacterial fouling at the surface (antifouling) [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces

et al. 2021

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Biocompatible smart interfaces play a crucial role in biomedical or tissue engineering applications, where their ability to actively change their conformation or physico-chemical properties permits finely tuning their surface attributes. Polyelectrolytes, such as acrylic acid, are a particular type of smart polymers that present pH responsiveness. This work aims to fabricate stable hydrogel films with reversible pH responsiveness that could spontaneously form wrinkled surface patterns. For this purpose, the photosensitive reaction mixtures were deposited via spin-coating over functionalized glasses. Following vacuum, UV, or either plasma treatments, it is possible to spontaneously form wrinkles, which could increase cell adherence. The pH responsiveness of the material was evaluated, observing an abrupt variation in the film thickness as a function of the environmental pH. Moreover, the presence of the carboxylic acid functional groups at the interface was evidenced by analyzing the adsorption/desorption capacity using methylene blue as a cationic dye model. The results demonstrated that increasing the acrylic acid in the microwrinkled hydrogel effectively improved the adsorption and release capacity and the ability of the carboxylic groups to establish ionic interactions with methylene blue. Finally, the role of the acrylic acid groups and the surface topography (smooth or wrinkled) on the final antibacterial properties were investigated, demonstrating their efficacy against both gram-positive and gram-negative bacteria model strains (E. coli and S. Aureus). According to our findings, microwrinkled hydrogels presented excellent antibacterial properties improving the results obtained for planar (smooth) hydrogels.

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Section: Resultssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces

et al. 2021

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“…Au wrinkling is not responsible for the improvement of fouling properties, though structured surfaces can reduce and direct cell adhesion . Compared to flat (nonshrunken, nonwrinkled) Au surfaces for both 25 and 60 kDa PCB, only Graft-then-Shrink, and not Shrink-then-Graft, surfaces were significantly different.…”

Section: Resultsmentioning

confidence: 87%

Graft-Then-Shrink: Simultaneous Generation of Antifouling Polymeric Interfaces and Localized Surface Plasmon Resonance Biosensors

Jesmer

Huynh

Marple

et al. 2021

ACS Appl. Mater. Interfaces

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Antifouling polymer coatings that are simple to manufacture are crucial for the performance of medical devices such as biosensors. “Grafting-to”, a simple technique where presynthesized polymers are immobilized onto surfaces, is commonly employed but suffers from nonideal polymer packing leading to increased biofouling. Herein, we present a material prepared via the grafting-to method with improved antifouling surface properties and intrinsic localized surface plasmon resonance (LSPR) sensor capabilities. A new substrate shrinking fabrication method, Graft-then-Shrink, improved the antifouling properties of polymer-coated Au surfaces by altering graft-to polymer packing while simultaneously generating wrinkled Au structures for LSPR biosensing. Thiol-terminated, antifouling, hydrophilic polymers were grafted to Au-coated prestressed polystyrene (PS) followed by shrinking upon heating above the PS glass transition temperature. Interestingly, the polymer molecular weight and hydration influenced Au wrinkling patterns. Compared to Shrink-then-Graft controls, where polymers are immobilized post shrinking, Graft-then-Shrink increased the polymer content by 76% in defined footprints and improved the antifouling properties as demonstrated by 84 and 72% reduction in macrophage adhesion and protein adsorption, respectively. Wrinkled Au LSPR sensors had sensitivities of ∼200–1000 Δλ/ΔRIU, comparing favorably to commercial LSPR sensors, and detected biotin–avidin and desthiobiotin–avidin complexation in a concentration-dependent manner using a standard plate reader and a 96-well format.

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“…[27,104] Mechanically, the optimal hierarchical design of nacre could achieve flaw tolerance at all levels and thus maximize toughness. [104,124] More extensive discussions on the mechanics of structural hierarchy [18,115,167,124] and corresponding biomimetic synthesis [147,166,168,169] can be found in the corresponding references.…”

Section: Structural Organization: Large Scale and Hierarchical Arrang...mentioning

confidence: 99%

Biomineralized Materials as Model Systems for Structural Composites: 3D Architecture

Jia

Deng

2022

Advanced Materials

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Biomineralized materials are sophisticated material systems with hierarchical 3D material architectures, which are broadly used as model systems for fundamental mechanical, materials science, and biomimetic studies. The current knowledge of the structure of biological materials is mainly based on 2D imaging, which often impedes comprehensive and accurate understanding of the materials’ intricate 3D microstructure and consequently their mechanics, functions, and bioinspired designs. The development of 3D techniques such as tomography, additive manufacturing, and 4D testing has opened pathways to study biological materials fully in 3D. This review discusses how applying 3D techniques can provide new insights into biomineralized materials that are either well known or possess complex microstructures that are challenging to understand in the 2D framework. The diverse structures of biomineralized materials are characterized based on four universal structural motifs. Nacre is selected as an example to demonstrate how the progression of knowledge from 2D to 3D can bring substantial improvements to understanding the growth mechanism, biomechanics, and bioinspired designs. State‐of‐the‐art multiscale 3D tomographic techniques are discussed with a focus on their integration with 3D geometric quantification, 4D in situ experiments, and multiscale modeling. Outlook is given on the emerging approaches to investigate the synthesis–structure–function–biomimetics relationship.

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Three-Dimensional Hierarchical Wrinkles on Polymer Films: From Chaotic to Ordered Antimicrobial Topographies

Cited by 15 publications

References 75 publications

Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces

Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces

Graft-Then-Shrink: Simultaneous Generation of Antifouling Polymeric Interfaces and Localized Surface Plasmon Resonance Biosensors

Biomineralized Materials as Model Systems for Structural Composites: 3D Architecture

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