2020
DOI: 10.21203/rs.2.23105/v1
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Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis

Abstract: KEYWORDSbrain angiogenesis; induced pluripotent stem cells; brain microvascular endothelial cells; microvascular tissue engineering; blood-brain barrier; brain capillaries 2 Abstract Background: During brain development, chemical cues released by developing neurons, cellular signaling with pericytes, and mechanical cues within the brain extracellular matrix (ECM) promote angiogenesis of brain microvascular endothelial cells (BMECs). Angiogenesis is also associated with diseases of the brain due to pathological… Show more

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