Three-dimensional macro/micro-porous curcumin releasing polycaprolactone/chitosan nanofiber scaffolds as wound dressing

Donkey Gelatin and Keratin Nanofibers Loaded with Antioxidant Agents for Wound Healing Dressings

“…The high dissolution of curcumin at 10 min can be explained by the transformation of curcumin in the electrospinning process from a crystalline to an amorphous state, leading to an increase in its free energy [ 52 ]. In other studies, due to the low solubility of curcumin in aqueous media, in vitro curcumin release investigations were conducted in PBS (pH 7.4) containing Tween 80 (0.4–0.5% ( wt / v )) and ethanol (10% v / v ) [ 19 , 59 ]. The release of antimicrobial and antioxidant agents was also reported in 90:10 water:ethanol at different temperatures for polyelectrolyte multilayer (PEM) thin films loaded with 5% ( wt / v ) curcumin for transdermal drug delivery applications [ 60 ] and 70% ethanol in the case of clotrimazole-loaded fabric testing [ 61 ].…”

“…For instance, curcumin (diferuloylmethane), a naturally derived polyphenol found in turmeric root, demonstrated anti-inflammatory and antioxidant characteristics, promoting keratinocyte migration and proliferation and showing potential benefits during the maturation phase of wound treatment [ 15 , 16 , 17 , 18 ]. To overcome the challenges associated with the low solubility of curcumin in aqueous solutions and limited bioavailability, researchers have investigated its incorporation into different carriers, such as chitosan/hyaluronic acid (HA)/poly(vinyl alcohol) (PVA)-magnetic montmorillonite (mMMt2) [ 15 ] and PCL-chitosan [ 19 ]. These prepared nanofibers demonstrated effectiveness in inhibiting the growth of E. coli and S. aureus bacteria [ 15 ] and had a positive impact on the viability and proliferation of human dermal fibroblasts (HDFs) [ 19 ].…”

“…To overcome the challenges associated with the low solubility of curcumin in aqueous solutions and limited bioavailability, researchers have investigated its incorporation into different carriers, such as chitosan/hyaluronic acid (HA)/poly(vinyl alcohol) (PVA)-magnetic montmorillonite (mMMt2) [ 15 ] and PCL-chitosan [ 19 ]. These prepared nanofibers demonstrated effectiveness in inhibiting the growth of E. coli and S. aureus bacteria [ 15 ] and had a positive impact on the viability and proliferation of human dermal fibroblasts (HDFs) [ 19 ]. Additionally, nanofibers containing curcumin, γ-polyglutamic acid, and gum arabic exhibited therapeutic potential in wound healing by accelerating the re-epithelialization process, enhancing wound contraction, and promoting the regeneration of new blood vessels and hair follicles [ 20 ].…”

Fabrication and Optimisation of Alumina Nanoporous Membranes for Drug Delivery Applications: A Comparative Study

“…From Table 6, it was found that the Higuchi model provided the most accurate representation of the release kinetics of donepezil from the calcined membranes. The Higuchi model is a commonly employed mathematical model for drug release from matrix systems, in which the rate of release is directly related to the square root of time [52]. This implies that the primary factor controlling the release of the medicine is the process of diffusion across the nanoporous membranes.…”