Three-dimensional magnetic resonance-based morphometrics and ventricular dysmorphology in schizophrenia

Buckley, Peter F.; Dean, David; Bookstein, Fred L.; Friedman, Lee; Kwon, David; Lewin, Jonathan S.; Kamath, Janardhan; Lys, Christine

doi:10.1016/s0006-3223(98)00067-5

Cited by 32 publications

(20 citation statements)

References 28 publications

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“…However, we also found differences in the central part of the lateral ventricle in the region of the corpus callosum. Although [2] also report differences in the temporal horn of male schizophrenics, they did not find differences in the pooled groups of male and females as we have reported here. Schizophrenia is a complex disease and, as the results of the linear discriminant analysis shows, there is a considerable overlap in the ventricles of schizophrenics and normals.…”

Section: Discussioncontrasting

confidence: 68%

“…Buckley et al [2] use 48 manually defined landmarks corresponding to curvature extrema on the surface of the ventricles of 20 schizophrenic patients and 20 control subjects to investigate shape differences. They considered the whole ventricular system and reported no overall shape differences between the entire patient group and the entire schizophrenic group.…”

Section: Related Workmentioning

confidence: 99%

“…Our approach has aspects in common with [2] and [5]. We build PDMs based on corresponding landmark points across a training set.…”

Section: Related Workmentioning

confidence: 99%

“…The landmark points are used to generate a small number of shape parameters controlling the modes of variation of the shapes. The use of this parametric description distinguishes our approach from that of [2]. However, the parameters are devised from the training data, unlike those of [5].…”

Section: Related Workmentioning

confidence: 99%

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An Investigation of Morphometric Changes in the Lateral Ventricles of Schizophrenic Subjects

Babalola

Graham

Honer

et al. 2003

Lecture Notes in Computer Science

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Abstract. We present results of morphometric analysis of the lateral ventricles of a group of schizophrenic and control subjects to investigate possible shape differences associated with schizophrenia. Our results show shape changes localised to three regions : the temporal horn (its tip near the amygdala, and along its body near the parahippocampal fissure), the central part of the lateral ventricles around the corpus callosum, and the tip of the anterior horn in the region of the frontal lobe. The differences in the temporal and anterior horns are in regions close to structures thought to be implicated in schizophrenia. The changes observed are the most significant changes (p < 10 −13 ) in shape parameters calculated using a 3D statistical shape descriptor (point distribution model). Corresponding points on the surface of the ventricles in the training set were obtained using an transportation-based method to match high curvature points.

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Section: Discussioncontrasting

confidence: 68%

Section: Related Workmentioning

confidence: 99%

“…Our approach has aspects in common with [2] and [5]. We build PDMs based on corresponding landmark points across a training set.…”

Section: Related Workmentioning

confidence: 99%

Section: Related Workmentioning

confidence: 99%

See 2 more Smart Citations

An Investigation of Morphometric Changes in the Lateral Ventricles of Schizophrenic Subjects

Babalola

Graham

Honer

et al. 2003

Lecture Notes in Computer Science

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“…Magnotta et al, 1999); (2) landmark based shape analysis (e.g. Arndt et al, 1996;Bookstein, 1991Bookstein, , 1997aBuckley et al,1999;Casanova et al,1990;Corson et al,1999a;DeQuardo et al, 1996DeQuardo et al, , 1999Tibbo et al, 1998); (3) surface parametrization techniques for shape extraction (e.g. Brechbühler et al, 1995;Narr et al, 2000); (4) skeletonization techniques for extracting shape (e.g.…”

Section: Summary Of Mri Findings and Future Directions For Researchmentioning

confidence: 99%

A review of MRI findings in schizophrenia

Shenton

Dickey

Frumin

et al. 2001

Schizophrenia Research

2,146

121

1,332

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After more than 100 years of research, the neuropathology of schizophrenia remains unknown and this is despite the fact that both Kraepelin (1919/1971: Kraepelin,E., 1919/1971. Dementia praecox. Churchill Livingston Inc., New York) and Bleuler (1911/1950: Bleuler, E., 1911/1950. Dementia praecox or the group of schizophrenias. International Universities Press, New York), who first described 'dementia praecox' and the ' schizophrenias', were convinced that schizophrenia would ultimately be linked to an organic brain disorder. Alzheimer (1897: Alzheimer, A., 1897. Beitrage zur pathologischen anatomie der hirnrinde und zur anatomischen grundlage einiger psychosen. Monatsschrift fur Psychiarie und Neurologie. 2, 82-120) was the first to investigate the neuropathology of schizophrenia, though he went on to study more tractable brain diseases. The results of subsequent neuropathological studies were disappointing because of conflicting findings. Research interest thus waned and did not flourish again until 1976, following the pivotal computer assisted tomography (CT) finding of lateral ventricular enlargement in schizophrenia by Johnstone and colleagues. Since that time significant progress has been made in brain imaging, particularly with the advent of magnetic resonance imaging (MRI), beginning with the first MRI study of schizophrenia by Smith and coworkers in 1984 (Smith, R.C., Calderon, M., Ravichandran, G. K., et al. (1984). Nuclear magnetic resonance in schizophrenia: A preliminary study. Psychiatry Res. 12, 137-147). MR in vivo imaging of the brain now confirms brain abnormalities in schizophrenia.The 193 peer reviewed MRI studies reported in the current review span the period from 1988 to August, 2000. This 12 year period has witnessed a burgeoning of MRI studies and has led to more definitive findings of brain abnormalities in schizophrenia than any other time period in the history of schizophrenia research. Such progress in defining the neuropathology of schizophrenia is largely due to advances in in vivo MRI techniques. These advances have now led to the identification of a number of brain abnormalities in schizophrenia. Some of these abnormalities confirm earlier postmortem findings, and most are small and subtle, rather than large, thus necessitating more advanced and accurate measurement tools. These findings include ventricular enlargement (80% of studies reviewed) and third ventricle enlargement (73% of studies reviewed). There is also preferential involvement of medial temporal lobe structures (74% of studies reviewed), which include the amygdala, hippocampus, and parahippocampal gyrus, and neocortical temporal lobe regions (superior temporal gyrus) (100% of studies reviewed). When gray and white matter of superior temporal gyrus was combined, 67% of studies reported abnormalities. There was also moderate evidence for frontal lobe abnormalities (59% of studies reviewed), particularly prefrontal gray matter and orbitofrontal regions. Similarly, there was moderate evidence for parietal lobe ab...

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Shape and Texture

Crum

2003

Quantitative MRI of the Brain

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Three-dimensional magnetic resonance-based morphometrics and ventricular dysmorphology in schizophrenia

Cited by 32 publications

References 28 publications

An Investigation of Morphometric Changes in the Lateral Ventricles of Schizophrenic Subjects

An Investigation of Morphometric Changes in the Lateral Ventricles of Schizophrenic Subjects

A review of MRI findings in schizophrenia

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