Three-Dimensional Multi-Frequency Shear Wave Absolute Vibro-Elastography (3D S-WAVE) With a Matrix Array Transducer: Implementation and Preliminary <i>In Vivo</i> Study of the Liver

Zeng, Qi; Honarvar, Mohammad; Schneider, Charles L.; Mohammad, Shahed Khan; Lobo, Julio; Pang, Emily; Lau, Kirby T.; Hu, Changhong; Jago, James; Erb, Siegfried R.; Rohling, Robert; Salcudean, Septimiu E.

doi:10.1109/tmi.2020.3034065

Cited by 27 publications

(16 citation statements)

References 69 publications

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“…Velacur (Sonic Incytes Medical Corp.) is a point-of-care liver assessment device based on Shear Wave Absolute Vibro-Elastography that incorporates elastography and a greater liver volume visualization. 168,169 LiverMultiScan uses multiparametric MRI to noninvasively quantify liver fat 170 and cT1 signal maps of the liver to assess disease activity (NAFLD activity score [NAS]) and potentially outcomes. 171,172 These techniques are currently being used largely in research for screening studies 5,173 or to assess primary end points in clinical trials for investigational drugs in development for the treatment of NASH.…”

Section: Q23 What Imaging Studies Can Be Used To Diagnose Nafld Withmentioning

confidence: 99%

American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings

et al. 2022

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Section: Q23 What Imaging Studies Can Be Used To Diagnose Nafld Withmentioning

confidence: 99%

American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings

et al. 2022

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“…This work represents a necessary step for extending the abilities of the ExactVu microUS system. The ability to image in 3D will allow for the implementation of cutting-edge 3D elastography methods [17], improved mpUS methods for prostate cancer diagnosis and biopsy guidance [27], or robotic surgery guidance [18].…”

Section: Future Workmentioning

confidence: 99%

“…The ExactVu microUS probe, on the other hand, does not have parallel axes between the handle of the probe and the element array, so rotating about the handle's principal axis will result in an incorrect 3D image with incorrect spatial geometry. The ability to acquire reliable 3D images using microUS will (i) allow for its inclusion in already-defined imaging workflows, such as 3D elastography [17], (ii) better facilitate MRI-to-US registration for fusion biopsies, (iii) allow for more accurate microUS-guided biopsies or brachytherapy without the necessity of MRI for volumetric information, and (iv) serve as an important tool in robotic surgery guidance [18].…”

Section: Introductionmentioning

confidence: 99%

Robotically-controlled three-dimensional micro-ultrasound for prostate biopsy guidance

Vassallo

Aleef

Zeng

et al. 2022

Preprint

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Purpose: Prostate imaging to guide biopsy remains unsatisfactory, with current solutions suffering from high complexity and poor accuracy and reliability. One novel entrant into this field is micro-ultrasound (microUS), which uses a high frequency imaging probe to achieve very high spatial resolution, and achieves prostate cancer detection rates equivalent to multiparametric magnetic resonance imaging (mpMRI). However, the ExactVu transrectal microUS probe has a unique geometry that makes it challenging to acquire controlled, repeatable three-dimensional (3D) transrectal ultrasound (TRUS) volumes. We describe the design, fabrication, and validation of a 3D acquisition system that allows for the accurate use of the ExactVu microUS device for volumetric prostate imaging. Methods: The design uses a motorized, computer-controlled brachytherapy stepper to rotate the ExactVu transducer about its axis. We carry geometric validation using a phantom with known dimensions and we compare performance with magnetic resonance imaging (MRI) using a commercial quality assurance anthropomorphic prostate phantom. Results: Our geometric validation shows accuracy of 1 mm or less in all three directions, and images of an anthropomorphic phantom qualitatively match those acquired using MRI and show good agreement quantitatively. Conclusion: We describe the first system to acquire robotically-controlled 3D microUS images using the ExactVu microUS system. The reconstructed 3D microUS images are accurate, which will allow for applications of the ExactVu microUS system in prostate specimen and in vivo imaging.

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“…While 3D S-WAVE data acquisition time is much shorter than that of MRE, it can still take up to 12 s for each patient. 1 During this acquisition time, patients need to hold their breath which is not practical for some elderly people, some sick patients, and children. The acquisition time is long because volumes are acquired by sectors whose size is limited by the number of input channels of the ultrasound machine.…”

Section: Introductionmentioning

confidence: 99%

Real-time 3D ultrafast shear wave absolute vibro-elastography

Hashemi

Mohammed

Azar³

et al. 2023

Medical Imaging 2023: Ultrasonic Imaging and Tomography

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3D ultrasound elastography has the potential to be a fast and accurate approach for estimating tissue shear modulus from the wave equation. One of the drawbacks of 3D imaging is the long data acquisition time which reduces practicality and can introduce artifacts from unwanted tissue motion such as from breathing. This paper presents a novel imaging technique for real-time 3D data collection with a volume rate of 2000 volumes/s and total acquisition time of 0.05 s. Plane wave imaging is used with Shear Wave Absolute Vibro-Elastography (S-WAVE) where an external mechanical vibration source generates multi-frequency shear waves in tissue. A matrix array transducer is used to collect volumes of radio frequency (RF) data. Axial, lateral and elevational displacements are then estimated over 3D volumes. The curl of the displacements is used in a local frequency estimation technique to estimate elasticity in the acquired volumes. The S-WAVE excitation frequency is substantially extended up to 500 Hz by using a high volume rate imaging. Therefore, the method can be applied on a wide range of applications such as prostate, breast, liver, and thyroid elastography. Results on liver fibrosis phantoms using several excitation frequencies are presented and compared with the manufacturer elasticity values for validation. The estimated elasticities by the proposed method fall within the manufacturer’s elasticity range for all frequencies.

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Three-Dimensional Multi-Frequency Shear Wave Absolute Vibro-Elastography (3D S-WAVE) With a Matrix Array Transducer: Implementation and Preliminary In Vivo Study of the Liver

Cited by 27 publications

References 69 publications

American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings

American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings

Robotically-controlled three-dimensional micro-ultrasound for prostate biopsy guidance

Real-time 3D ultrafast shear wave absolute vibro-elastography

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