Three-dimensional Multistructural Quantitative Photoacoustic and US                     Imaging of Human Feet in Vivo

Choi, Wonseok; Park, Eun-Yeong; Jeon, Seungwan; Yang, Yeoree; Park, Byullee; Ahn, Jae-Sung; Cho, Seonghee; Lee, Changyeop; Seo, Dong-Kyo; Cho, Jae-Hyoung; Kim, Chulhong

doi:10.1148/radiol.211029

Cited by 74 publications

(58 citation statements)

References 31 publications

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“…In most cases, the quantification of sO 2 level has been used for detecting tumor hypoxia, which is one of the well-known characteristics of cancerous tissue [ 100 ]. Using the functional information of PAI, clinical trials have been conducted for visualizing, diagnosing, and analyzing tissue in various clinical applications including cancers [ 36 , 101 ], melanoma [ 52 , 53 ], and vascular diseases [ 102 ].…”

Section: Discussion and Outlookmentioning

confidence: 99%

Review on Multispectral Photoacoustic Analysis of Cancer: Thyroid and Breast

et al. 2022

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In recent decades, photoacoustic imaging has been used widely in biomedical research, providing molecular and functional information from biological tissues in vivo. In addition to being used for research in small animals, photoacoustic imaging has also been utilized for in vivo human studies, achieving a multispectral photoacoustic response in deep tissue. There have been several clinical trials for screening cancer patients by analyzing multispectral responses, which in turn provide metabolomic information about the underlying biological tissues. This review summarizes the methods and results of clinical photoacoustic trials available in the literature to date to classify cancerous tissues, specifically of the thyroid and breast. From the review, we can conclude that a great potential exists for photoacoustic imaging to be used as a complementary modality to improve diagnostic accuracy for suspicious tumors, thus significantly benefitting patients’ healthcare.

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Section: Discussion and Outlookmentioning

confidence: 99%

Review on Multispectral Photoacoustic Analysis of Cancer: Thyroid and Breast

et al. 2022

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“…The imaging speed can be significantly improved in array-based PAI systems compared to single-element PAI systems because multiple elements achieve PA signals simultaneously, thereby producing a larger imaging region with a single laser pulse. The spatial resolution and image quality may be degraded by mathematical image reconstruction procedures; however, the fast imaging speed and deep penetration depth of array-based PAI systems are beneficial for biomedical applications, especially in clinical human research [ 29 , 30 , 31 , 32 ].…”

Section: Photoacoustic Imaging With Array Transducermentioning

confidence: 99%

Whole-Body Photoacoustic Imaging Techniques for Preclinical Small Animal Studies

Kye

Song

Kim

et al. 2022

Sensors

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Photoacoustic imaging is a hybrid imaging technique that has received considerable attention in biomedical studies. In contrast to pure optical imaging techniques, photoacoustic imaging enables the visualization of optical absorption properties at deeper imaging depths. In preclinical small animal studies, photoacoustic imaging is widely used to visualize biodistribution at the molecular level. Monitoring the whole-body distribution of chromophores in small animals is a key method used in preclinical research, including drug-delivery monitoring, treatment assessment, contrast-enhanced tumor imaging, and gastrointestinal tracking. In this review, photoacoustic systems for the whole-body imaging of small animals are explored and summarized. The configurations of the systems vary with the scanning methods and geometries of the ultrasound transducers. The future direction of research is also discussed with regard to achieving a deeper imaging depth and faster imaging speed, which are the main factors that an imaging system should realize to broaden its application in biomedical studies.

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“…In the overlaid images, both the anatomical (from USI) and metabolomic (from PAI) information of biological tissue can be simultaneously visualized. Therefore, the combined PAUSI information has been applied to various clinical human studies, including thyroid cancer detection [ 9 , 61 , 62 ], prostate cancer imaging [ 63 , 64 ], skin disease assessment [ 13 , 14 ], inflammation detection [ 65 ], and peripheral vasculature imaging [ 66 , 67 ].…”

Section: Photoacoustic Computed Tomographymentioning

confidence: 99%

State of the Art in Carbon Nanomaterials for Photoacoustic Imaging

et al. 2022

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Photoacoustic imaging using energy conversion from light to ultrasound waves has been developed as a powerful tool to investigate in vivo phenomena due to their complex characteristics. In photoacoustic imaging, endogenous chromophores such as oxygenated hemoglobin, deoxygenated hemoglobin, melanin, and lipid provide useful biomedical information at the molecular level. However, these intrinsic absorbers show strong absorbance only in visible or infrared optical windows and have limited light transmission, making them difficult to apply for clinical translation. Therefore, the development of novel exogenous contrast agents capable of increasing imaging depth while ensuring strong light absorption is required. We report here the application of carbon nanomaterials that exhibit unique physical, mechanical, and electrochemical properties as imaging probes in photoacoustic imaging. Classified into specific structures, carbon nanomaterials are synthesized with different substances according to the imaging purposes to modulate the absorption spectra and highly enhance photoacoustic signals. In addition, functional drugs can be loaded into the carbon nanomaterials composite, and effective in vivo monitoring and photothermal therapy can be performed with cell-specific targeting. Diverse applied cases suggest the high potential of carbon nanomaterial-based photoacoustic imaging in in vivo monitoring for clinical research.

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Three-dimensional Multistructural Quantitative Photoacoustic and US Imaging of Human Feet in Vivo

Cited by 74 publications

References 31 publications

Review on Multispectral Photoacoustic Analysis of Cancer: Thyroid and Breast

Review on Multispectral Photoacoustic Analysis of Cancer: Thyroid and Breast

Whole-Body Photoacoustic Imaging Techniques for Preclinical Small Animal Studies

State of the Art in Carbon Nanomaterials for Photoacoustic Imaging

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