Three-Dimensional-Printed Bioengineered Tracheal Grafts: Preclinical Results and Potential for Human Use

Rehmani, Sadiq; Al-Ayoubi, Adnan M.; Ayub, Adil; Barsky, M.; Lewis, Eric; Flores, Raja M.; Lebovics, Robert S.; Bhora, Faiz Y.

doi:10.1016/j.athoracsur.2017.03.051

Cited by 50 publications

(35 citation statements)

References 48 publications

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“…The animals had to be euthanized prior to the end of the study due to respiratory distress secondary to tracheal narrowing at the reconstruction site (Townsend et al, 2018). On the other hand, Rehmani et al reconstructed a 40 × 16 mm defect in 7 pigs with a PCL implant covered with an extracellular matrix and found that 5 pigs had well-sized tracheal lumen with minimal stenosis and granulation tissue after 3 months (Rehmani et al, 2017).…”

Section: Non-circumferential Reconstructionmentioning

confidence: 99%

“…They are simple to manage, extensively available, and cost-effective for interventional studies (Park et al, 2018a). Nevertheless, dog, sheep, and pig models might be better to reproduce the size of teenagers with adult sized tracheas, but these large animals are difficult to manage post-operatively and are more expensive (Zopf et al, 2014;Townsend et al, 2018;Rehmani et al, 2017).…”

Section: Animal Modelsmentioning

confidence: 99%

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3D-bioprinted tracheal reconstruction: an overview

Frejo

Grande

2019

Bioelectron Med

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Congenital tracheomalacia and tracheal stenosis are commonly seen in premature infants. In adulthood, are typically related with chronic obstructive pulmonary disease, and can occur secondarily from tracheostomy, prolong intubation, trauma, infection and tumors. Both conditions are life-threatening when not managed properly. There are still some surgical limitations for certain pathologies, however tissue engineering is a promising approach to treat massive airway dysfunctions. 3D-bioprinting have contributed to current preclinical and clinical efforts in airway reconstruction. Several strategies have been used to overcome the difficulty of airway reconstruction such as scaffold materials, construct designs, cellular types, biologic components, hydrogels and animal models used in tracheal reconstruction. Nevertheless, additional long-term in vivo studies need to be performed to assess the efficacy and safety of tissue-engineered tracheal grafts in terms of mechanical properties, behavior and, the possibility of further stenosis development.

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Section: Non-circumferential Reconstructionmentioning

confidence: 99%

Section: Animal Modelsmentioning

confidence: 99%

3D-bioprinted tracheal reconstruction: an overview

Frejo

Grande

2019

Bioelectron Med

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“…After 3D segmentation of the animals' airways, a custom tracheal segment was designed and then printed. The additional use of an extracellular matrix provided a substratum for mucosal coverage and epithelialization of the graft [14].…”

Section: D Bioprintingmentioning

confidence: 99%

Integration of 3D printing and additive manufacturing in the interventional pulmonologist's toolbox

Guibert

Mhanna

Didier

et al. 2018

Respiratory Medicine

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New 3D technologies are rapidly entering into the surgical landscape, including in interventional pulmonology. The transition of 2D restricted data into a physical model of pathological airways by three-dimensional printing (3DP) allows rapid prototyping and fabrication of complex and patient-specific shapes and can thus help the physician to plan and guide complex procedures. Furthermore, computer-assisted designed (CAD) patient-specific devices have already helped surgeons overcome several therapeutic impasses and are likely to rapidly cover a wider range of situations. We report herein with a special focus on our clinical experience: i) how additive manufacturing is progressively integrated into the management of complex central airways diseases; ii) the appealing future directions of these new technologies, including the potential of the emerging technique of bioprinting; iii) the main pitfalls that could delay its introduction into routine care.

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“…In addition, they demonstrated that safe and clinically used material can be processed to create customized anatomically precise tracheal grafts. These outstanding initial results will help shape reconstructive surgery in both adult and pediatric populations with congenital and malignant disease processes (7,8).…”

mentioning

confidence: 99%

Confronting the fundamental challenges of airway surgery: a paradigm shift is practically upon us

Lazar

2017

J. Thorac. Dis.

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Three-Dimensional-Printed Bioengineered Tracheal Grafts: Preclinical Results and Potential for Human Use

Cited by 50 publications

References 48 publications

3D-bioprinted tracheal reconstruction: an overview

3D-bioprinted tracheal reconstruction: an overview

Integration of 3D printing and additive manufacturing in the interventional pulmonologist's toolbox

Confronting the fundamental challenges of airway surgery: a paradigm shift is practically upon us

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