Three Dimensional Quantitative Coronary Angiography Can Detect Reliably Ischemic Coronary Lesions Based on Fractional Flow Reserve

Chung, Woo-Young; Choi, Byoung‐Joo; Lim, Seong Hoon; Matsuo, Yoshiki; Lennon, Ryan J.; Gulati, Rajiv; Sandhu, Gurpreet S.; Holmes, David R.; Rihal, Charanjit S.; Lerman, Amir

doi:10.3346/jkms.2015.30.6.716

Cited by 13 publications

(2 citation statements)

References 27 publications

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“…41 Characteristic for such angiography is that vessels branch off large primary vessels to subsequently smaller ones, and typically without collaterals. 42 The outflow tract of the eyes is different and has a much more diffuse and connected nexus of vessels with variable caliber.…”

Section: Discussionmentioning

confidence: 99%

Quantification of Focal Outflow Enhancement Using Differential Canalograms

Loewen

Brown

Scott

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PurposeTo quantify regional changes of conventional outflow caused by ab interno trabeculectomy (AIT).MethodsGonioscopic, plasma-mediated AIT was established in enucleated pig eyes. We developed a program to automatically quantify outflow changes (R, package eye-canalogram, github.com) using a fluorescent tracer reperfusion technique. Trabecular meshwork (TM) ablation was demonstrated with fluorescent spheres in six eyes before formal outflow quantification with two-dye reperfusion canalograms in six additional eyes. Eyes were perfused with a central, intracameral needle at 15 mm Hg. Canalograms and histology were correlated for each eye.ResultsThe pig eye provided a model with high similarity to AIT in human patients. Histology indicated ablation of TM and unroofing of most Schlemm's canal segments. Spheres highlighted additional circumferential and radial outflow beyond the immediate area of ablation. Differential canalograms showed that AIT caused an increase of outflow of 17 ± 5-fold inferonasally, 14 ± 3-fold superonasally, and also an increase in the opposite quadrants with a 2 ± 1-fold increase superotemporally, and 3 ± 3 inferotemporally. Perilimbal specific flow image analysis showed an accelerated nasal filling with an additional perilimbal flow direction into adjacent quadrants.ConclusionsA quantitative, differential canalography technique was developed that allows us to quantify supraphysiological outflow enhancement by AIT.

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Section: Discussionmentioning

confidence: 99%

Quantification of Focal Outflow Enhancement Using Differential Canalograms

Loewen

Brown

Scott

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…The absence of an automated, standardized method to quantify aqueous humor outflow at a discrete anatomic location, analogous to quantitative coronary angiography,[ 11 , 12 ] has been an obstacle in glaucoma research. Such a technique would be especially useful for investigations into outflow resistance elements that may be downstream of the trabecular meshwork implicated in glaucoma,[ 13 ] and have been suggested to be the cause for late failure of canal-based microincisional glaucoma surgeries.…”

Section: Introductionmentioning

confidence: 99%

Regionally Discrete Aqueous Humor Outflow Quantification Using Fluorescein Canalograms

et al. 2016

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PurposeTo visualize and quantify conventional outflow directly in its anatomic location.MethodsWe obtained fluorescein canalograms in six porcine whole eyes and six porcine anterior segment cultures. Eyes were perfused with a constant pressure of 15 mmHg using media containing 0.017 mg/ml fluorescein. Flow patterns were visualized using a stereo dissecting microscope equipped for fluorescent imaging. Images were captured every 30 seconds for 20 minutes for time lapse analysis. Anterior chamber cultures were imaged again on day three of culture. Canalograms were first analyzed for filling time per quadrant. We then wrote a program to automatically compute focal flow fits for each macropixel and to detect convergent perilimbal flow patterns with macropixels grouped into 3 equal-radial width rings around the cornea. A generalized additive model was used to determine fluorescence changes of individual macropixels.ResultsThe resulting imaging algorithm deployed 1024 macropixels that were fit to determine maximum intensity and time to fill. These individual fits highlighted the focal flow function. In whole eyes, significantly faster flow was seen in the inferonasal (IN) and superonasal (SN) quadrants compared to the superotemporal (ST) and inferotemporal (IT) ones (p<0.05). In anterior chamber cultures, reduced flow on day 1 increased in all quadrants on day 3 except in IT (p<0.05). Perilimbal ring analysis uncovered convergent perilimbal flow.ConclusionsAn algorithm was developed that analyzes regional and circumferential outflow patterns. This algorithm found flow patterns that changed over time and differ in whole eyes and anterior segment cultures.

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A systematic review of imaging anatomy in predicting functional significance of coronary stenoses determined by fractional flow reserve

Chu

Yang

Westra

et al. 2017

Int J Cardiovasc Imaging

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Fractional flow reserve (FFR) is the current gold standard to assess the physiological significance of coronary stenoses. With the development of coronary imaging techniques, several anatomic parameters have been investigated in vivo and their associations with FFR have been studied. The aim of this review is to summarize the accuracy of anatomic parameters derived by the present coronary imaging techniques including invasive coronary angiography, coronary computed tomography angiography, intravascular ultrasound and optical coherence tomography, in predicting a significant FFR. The impact of patient characteristics, lesion locations, variability of FFR and imaging resolution on the predictive ability are discussed.

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Three Dimensional Quantitative Coronary Angiography Can Detect Reliably Ischemic Coronary Lesions Based on Fractional Flow Reserve

Cited by 13 publications

References 27 publications

Quantification of Focal Outflow Enhancement Using Differential Canalograms

Quantification of Focal Outflow Enhancement Using Differential Canalograms

Regionally Discrete Aqueous Humor Outflow Quantification Using Fluorescein Canalograms

A systematic review of imaging anatomy in predicting functional significance of coronary stenoses determined by fractional flow reserve

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