Three-dimensional right-ventricular regional deformation and survival in pulmonary hypertension

Moceri, Pamela; Duchateau, Nicolás; Baudouy, Delphine; Schouver, Elie-Dan; Leroy, Sylvie; Squara, Fabien; Ferrari, Émile; Sermesant, Maxime

doi:10.1093/ehjci/jex163

Cited by 72 publications

(90 citation statements)

References 44 publications

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“…A similar response can be recognized in patients with pulmonary arterial hypertension, and the prognostic value of this phenomenon is well established. 24,25 Post-operative shift in right ventricular contraction pattern…”

Section: Adaptation To Chronic Primary Mitral Valve Regurgitationmentioning

confidence: 99%

Right ventricular mechanical pattern in patients undergoing mitral valve surgery: a predictor of post‐operative dysfunction?

et al. 2020

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Aims The PREPARE-MVR study (PRediction of Early PostoperAtive Right vEntricular failure in Mitral Valve Replacement/Repair patients) sought to investigate the alterations of right ventricular (RV) contraction pattern in patients undergoing mitral valve replacement/repair (MVR) and to explore the associations between pre-operative RV mechanics and early post-operative RV dysfunction (RVD). Methods and resultsWe prospectively enrolled 42 patients (63 ± 11 years, 69% men) undergoing open-heart MVR. Transthoracic three-dimensional (3D) echocardiography was performed pre-operatively, at intensive care unit discharge, and 6 months after surgery. The 3D model of the RV was reconstructed, and RV ejection fraction (RVEF) was calculated. We decomposed the motion of the ventricle to compute longitudinal ejection fraction (LEF) and radial ejection fraction (REF). Pulmonary artery catheterization was performed to monitor RV stroke work index (RVSWi). RVEF was slightly decreased after vs. 51 (46-54)%; P = 0.001], whereas RV contraction pattern changed notably. Before MVR, the longitudinal shortening was the main contributor to global systolic RV function [LEF/RVEF vs. REF/RVEF; 0.53 (0.47-0.58) vs. 0.33 (0.22-0.42); P < 0.001]. Post-operatively, the radial motion became dominant [0.33 (0.28-0.43) vs. 0.46 (0.37-0.51); P = 0.004].However, this shift was temporary as 6 months later the two components contributed equally to global RV function [0.44 (0.38-0.50) vs. 0.41 (0.36-0.49); P = 0.775]. Pre-operative LEF was an independent predictor of post-operative RVD defined as RVSWi < 300 mmHgÁmL/m 2 [OR = 1.33 (95% CI: 1.08-1.77), P < 0.05]. Conclusions MVR induces a significant shift in the RV mechanical pattern. Advanced indices of RV mechanics are associated with invasively measured parameters of RV contractility and may predict post-operative RVD.

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Section: Adaptation To Chronic Primary Mitral Valve Regurgitationmentioning

confidence: 99%

Right ventricular mechanical pattern in patients undergoing mitral valve surgery: a predictor of post‐operative dysfunction?

et al. 2020

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“…have shown that longitudinal strain measured from the entire RV fee wall correlates well with RV contractile function while the novel study from Moceri et al. found that right ventricular strain patterns worsen in pulmonary hypertension patients and provide independent prognostic information in that population …”

Section: Discussionmentioning

confidence: 99%

2D speckle tracking echocardiography of the right ventricle free wall in SCUBA divers after single open sea dive

Susilovic-Grabovac

Obad

Duplančić

et al. 2017

Clin Exp Pharma Physio

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The presence of circulating gas bubbles and their influence on pulmonary and right heart hemodynamics was reported after uncomplicated self-contained underwater breathing apparatus (SCUBA) dive(s). Improvements in cardiac imaging have recently focused great attention on the right ventricle (RV). The aim of our study was to evaluate possible effects of a single air SCUBA dive on RV function using 2D speckle tracking echocardiography in healthy divers after single open sea dive to 18 meters of seawater, followed by bottom stay of 47 minutes with a direct ascent to the surface. Twelve experienced male divers (age 39.5 ± 10.5 years) participated in the study. Echocardiographic assessment of the right ventricular function (free wall 2 D strain, tricuspid annular planes systolic excursion [TAPSE], lateral tricuspid annular peak systolic velocity [RV s`] and fractional area change [FAC]) was performed directly prior to and 30, 60, 90 and 120 minutes after surfacing. Two-dimensional strain of all three segments of free right ventricular wall showed a significant increase in longitudinal shortening in post-dive period for maximally 26% (basal), 15.4% (mid) and 16.3% (apical) as well as TAPSE (11.6%), RV FAC (19.2%), RV S` (12.7%) suggesting a rise in systolic function of right heart. Mean pulmonary arterial pressure (mean PAP) increased post-dive from 13.3 mmHg to maximally 23.5 mmHg (P = .002), indicating increased RV afterload. Our results demonstrated that single dive with significant bubble load lead to increase in systolic function and longitudinal strain of the right heart in parallel with increase in mean PAP.

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“…At present, most of the data in this area has investigated global longitudinal strain [15][16][17][18][19]. Area strain, a measure of relative area change that incorporates longitudinal and circumferential strain, holds promise as a useful clinical tool [20].…”

Section: Right Ventricular Systolic Functionmentioning

confidence: 99%

State-of-the-Art Review: Echocardiography in Pulmonary Hypertension

Cordina

Playford

Lang

et al. 2019

Heart, Lung and Circulation

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Three-dimensional right-ventricular regional deformation and survival in pulmonary hypertension

Abstract: Right ventricular strain patterns gradually worsen in PH patients and provide independent prognostic information in this population.

Cited by 72 publications

References 44 publications

Right ventricular mechanical pattern in patients undergoing mitral valve surgery: a predictor of post‐operative dysfunction?

Right ventricular mechanical pattern in patients undergoing mitral valve surgery: a predictor of post‐operative dysfunction?

2D speckle tracking echocardiography of the right ventricle free wall in SCUBA divers after single open sea dive

State-of-the-Art Review: Echocardiography in Pulmonary Hypertension

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