“…1,4,5 The addition of the frontomaxillary angle, maxillary and mandibular bone lengths, prefrontal diameter, and 3D ultrasonographic retronasal triangle, emphasizing the evaluation of the nasal bones, are other feasible soft markers for an early diagnosis of chromosomal abnormalities. 2,6,7 Therefore, further studies with a larger number of cases and longer range of gestational age to confirm the results we have presented and establish an accurate reference range for the Taiwanese population are warranted. …”