Three‐Dimensional Speckle Tracking Echocardiography Allows Detailed Evaluation of Left Atrial Function in Hypertrophic Cardiomyopathy–Insights from the <scp>MAGYAR</scp>‐Path Study

Domsik, Péter; Kalapos, Anita; Chadaide, Számi; Sepp, Róbert; Hausinger, Péter; Forster, Tamás; Nemes, Attila

doi:10.1111/echo.12568

Cited by 39 publications

(55 citation statements)

References 42 publications

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“…3): [1] Reservoir function (LA inflow during LA systole), [2] Conduit function (LA passive emptying during LV relaxation and diastasis, when blood transiting from the pulmonary veins to the LV during early diastole), [3] Active contraction or booster pump function (LA active emptying, when LA works like an active contractile chamber that augments LV filling in late diastole). There are several ways for functional assessment of LA including calculation of volumebased and strain parameters by 3DSTE as demonstrated before (4,7,8,11,13,15,18). With these parameters detailed characterization of all three LA functions possible: [1] Reservoir function by total atrial SV and total atrial EF together with global and mean segmental peak strain parameters, [2] Conduit function by passive atrial SV and passive atrial EF, and [3] Active contraction (booster pump) by active atrial SV and active atrial EF together with global and mean segmental pre-atrial contraction strain parameters.…”

Section: Discussionmentioning

confidence: 99%

“…In the AP4CH and AP2CH views, the LA endocardial boundaries were manually traced by setting multiple reference points starting at the mitral valve level going toward the LA apex. Regarding to the literature LA appendage and pulmonary veins were not considered as the part of the LA cavity during 3DSTE assessments (7,18). The epicardial border was adjusted manually or by setting a default thickness for the myocardium.…”

Section: Dste-derived Volumetric Measurementsmentioning

confidence: 99%

“…The user could manually adjust endocardial and epicardial LA surface when it was necessary. The following volumes have been calculated (7,8,11,15,18):…”

Section: Dste-derived Volumetric Measurementsmentioning

confidence: 99%

“…From the same 3D echocardiographic dataset the following LA deformation parameters were calculated (4,7,13,14) (Fig. 2): [1] Longitudinal strain (strain in the direction parallel to the endocardial contour), [2] Circumferential strain (fiber shortening along the circular perimeter, strain in the circumferential direction),…”

Section: Dste-derived Strain Measurementsmentioning

confidence: 99%

“…Arterial stiffness was found to be associated with LA size in different patient populations (12). Three-dimensional (3D) speckle-tracking echocardiography (STE) seems to be an optimal choice for non-invasive quantification of LV and LA volumes and deformation parameters by 3D volumetric and strain analysis (1,4,7,8,11,13,15,(17)(18)(19)22). The aim of the present study was to determine whether correlations exist between 3DSTE-derived LA volume-based and strain parameters characterizing all phasic functions of the LA and echocardiographic aortic elastic properties in healthy subjects.…”

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confidence: 99%

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Correlations between three-dimensional speckle-tracking echocardiography-derived left atrial functional parameters and aortic stiffness in healthy subjects – Results from the MAGYAR-Healthy Study

Nemes

Piros

Domsik

et al. 2015

Acta Physiologica Hungarica

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Left atrial (LA) distension has been demonstrated to be linked with aortic stiffness in different patient populations. Three-dimensional (3D) speckle-tracking echocardiography (STE) seems to be a promising tool for volumetric and functional evaluation of the LA. The aim of the present study was to determine whether correlations exist between 3DSTE-derived LA volume-based and strain parameters characterizing all phasic functions of the LA and echocardiographic aortic elastic properties in healthy subjects. The study included 19 healthy volunteers (mean age: 37.9 ± 11.4 years, 11 men) who had undergone complete two-dimensional (2D) Doppler transthoracic echocardiography extended with the assessment of aortic elastic properties and 3DSTE. Results: None of LA volumes correlated with echocardiographic aortic elastic properties. Active atrial stroke volume correlated with aortic stiffness index (ASI, r = 0.45, p = 0.05). None of other volume-based functional properties significantly correlated with aortic stiffness parameters. Global peak 3D strain correlated with aortic strain (r = -0.46, p = 0.05). Global radial pre-atrial contraction strain correlated with ASI (r = -0.49, p = 0.04) and AS (r = -0.50, p = 0.04). Conclusions:Correlations exist between 3DSTE-derived LA functional parameters and eschocardiographic aortic elastic properties in healthy subjects.Keywords: aortic, distensibility, echocardiography, function, left atrium, speckle-tracking, stiffness, threedimensionalThere is a strong interplay between vascular and cardiac mechanics including arterialventricular coupling. Left ventricular (LV) remodeling is a powerful determinant of left atrial (LA) size, therefore arterial stiffness could influence LA dimensions, as well (5, 6, 12). Arterial stiffness was found to be associated with LA size in different patient populations (12). Three-dimensional (3D) speckle-tracking echocardiography (STE) seems to be an optimal choice for non-invasive quantification of LV and LA volumes and deformation parameters by 3D volumetric and strain analysis (1,4,7,8,11,13,15,(17)(18)(19)22). The aim of the present study was to determine whether correlations exist between 3DSTE-derived LA volume-based and strain parameters characterizing all phasic functions of the LA and echocardiographic aortic elastic properties in healthy subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Dste-derived Volumetric Measurementsmentioning

confidence: 99%

“…The user could manually adjust endocardial and epicardial LA surface when it was necessary. The following volumes have been calculated (7,8,11,15,18):…”

Section: Dste-derived Volumetric Measurementsmentioning

confidence: 99%

Section: Dste-derived Strain Measurementsmentioning

confidence: 99%

mentioning

confidence: 99%

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Correlations between three-dimensional speckle-tracking echocardiography-derived left atrial functional parameters and aortic stiffness in healthy subjects – Results from the MAGYAR-Healthy Study

Nemes

Piros

Domsik

et al. 2015

Acta Physiologica Hungarica

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Assessment of subclinical left atrial myocardial dysfunction in essential hypertension patients with normal left ventricle function by two‐dimensional strain and volume‐derived variables

Huang

Yang

et al. 2021

J of Clinical Ultrasound

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Purpose: To investigate subclinical left atrial (LA) myocardial dysfunction in essential hypertension (EHT) patients by using volume-derived and two-dimensional strain.Methods: We enrolled in this study 51 normal subjects and 95 EHT patients. The LA volume-derived index was measured in apical 4-and 2-chamber views. LA strain and strain rate, reservoir, conduit, and booster pump functions were measured by twodimensional speckle tracking echocardiography (STE).Results: LA ejection fraction (LAEF) and absolute strain-derived values were significantly lower in EHT patients than in controls. LAEF (total, passive), absolute values of LA strain (S-reservoir and S-conduit), and strain rate (Sr-reservoir and Sr-conduit) were significantly lower in EHT patients with left ventricular hypertrophy (LVH) than in patients without LVH and in controls. However, there were no significant difference in active LAEF or S-booster pump and Sr-booster pump functions between EHT patients without LVH and normal subjects. The areas under the curves of the combination of volume-derived values, LA strain, and strain rate were significantly higher than those of individual indices. Conclusion:In our population, EHT patients showed impaired LA functions and greater stiffness than normal subjects. EHT patients with LVH showed greater impairment of LA reservoir and conduit functions than patients without LVH. EHT patients without LVH had normal LA booster pump function, which was impaired in patients with LVH. Volume-derived and 2D strain values could provide a sensitive and reproducible method for detecting subclinical LA myocardial dysfunction in EHT.

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Modulation of signal transduction through the cellular prion protein is linked to its incorporation in lipid rafts

Hugel

Martínez

Kunzelmann

et al. 2004

CMLS, Cell. Mol. Life Sci.

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Because expressed at a significant level at the membrane of human T cells, we made the hypothesis that the cellular prion protein (PrPc) could behave as a receptor, and be responsible for signal transduction. PrPc engagement by specific antibodies was observed to induce an increase in cytosolic calcium concentration and led to enhanced activity of Src protein tyrosine kinases. Antibodies to CD4 and CD59 did not influence calcium fluxes or signaling. The effect was maximal after the formation of a network involving avidin and biotinylated antibody to PrPc and was inhibited after raft disruption. PrPc localization was not restricted to rafts in resting cells but engagement was a prerequisite for signaling induction, with concomitant PrPc recruitment into rafts. These results suggest a role for PrPc in signaling pathways, and show that lateral redistribution of the protein into rafts is important for subsequent signal transduction.

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Three‐Dimensional Speckle Tracking Echocardiography Allows Detailed Evaluation of Left Atrial Function in Hypertrophic Cardiomyopathy–Insights from the MAGYAR‐Path Study

Abstract: Three-dimensional speckle tracking echocardiography allows detailed evaluation of LA (dys) function in HCM by volumetric and strain measurements.

Cited by 39 publications

References 42 publications

Correlations between three-dimensional speckle-tracking echocardiography-derived left atrial functional parameters and aortic stiffness in healthy subjects – Results from the MAGYAR-Healthy Study

Correlations between three-dimensional speckle-tracking echocardiography-derived left atrial functional parameters and aortic stiffness in healthy subjects – Results from the MAGYAR-Healthy Study

Assessment of subclinical left atrial myocardial dysfunction in essential hypertension patients with normal left ventricle function by two‐dimensional strain and volume‐derived variables

Modulation of signal transduction through the cellular prion protein is linked to its incorporation in lipid rafts

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