Three-dimensional spin-lock magnetic resonance imaging of the shoulder joint at 3 T: initial experience

Vieira, Renata; Pakin, S. Kubilay; Cavalcanti, Conrado Furtado de Albuquerque; Schweitzer, Mark E.; Regatte, Ravinder R.

doi:10.1007/s00256-007-0368-5

Cited by 6 publications

(7 citation statements)

References 17 publications

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“…A composite spin‐lock pulse showing the tolerance to shimming and RF errors was designed to allow spin locking with relatively weak RF (low spin‐lock frequency) and therefore low specific energy absorption rate (SAR) . A “self‐compensated” spin‐locking pulse with the phase of the second half of the spin‐lock pulse being shifted 180° from the first half was proposed to reduce the artifacts due to the B 1 inhomogeneity. Application of spin‐locking pulses in a system with species at a range of chemical shifts or in a system with significant B 0 inhomogeneity can result in more complex rotations arising from off‐resonance spin‐locking.…”

Section: History Of T1ρ Pulse Sequence Developmentmentioning

confidence: 99%

T_1ρ MRI of human musculoskeletal system

Wang

Regatte

2014

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) offers the direct visualization of human musculoskeletal (MSK) system, especially all diarthrodial tissues including cartilage, bone, menisci, ligaments, tendon, hip, synovium etc. Conventional MR imaging techniques based on T1- and T2-weighted, proton density (PD) contrast are inconclusive in quantifying early biochemically degenerative changes in MSK system in general and articular cartilage in particular. In recent years, quantitative MR parameter mapping techniques have been used to quantify the biochemical changes in articular cartilage with a special emphasis on evaluating joint injury, cartilage degeneration, and soft tissue repair. In this article, we will focus on cartilage biochemical composition, basic principles of T1ρ MR imaging, implementation of T1ρ pulse sequences, biochemical validation, and summarize the potential applications of T1ρ MR imaging technique in MSK diseases including osteoarthritis (OA), anterior cruciate ligament (ACL) injury, and knee joint repair. Finally, we will also review the potential advantages, challenges, and future prospects of T1ρ MR imaging for widespread clinical translation.

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Section: History Of T1ρ Pulse Sequence Developmentmentioning

confidence: 99%

T_1ρ MRI of human musculoskeletal system

Wang

Regatte

2014

Magnetic Resonance Imaging

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“…T1rho (or T1ρ- T1 relaxation time in the rotating frame)-weighted MR imaging has recently been proposed as a promising alternative biomarker to existing conventional morphological MRI methods (14–16). Related techniques have been used to investigate the slow motion interactions between macromolecular protons and bulk water.…”

Section: Introductionmentioning

confidence: 99%

“…Related techniques have been used to investigate the slow motion interactions between macromolecular protons and bulk water. Previous studies have shown that T1rho mapping is sensitive to biochemical changes in proteoglycan (PG) loss in hyaline cartilage (14, 15, 17, 18) and menisci (19, 20) with early OA. T1rho mapping technique may be a pre-structural indicator of OA (16, 19, 20).…”

Section: Introductionmentioning

confidence: 99%

Relationship between knee alignment and T1ρ values of articular cartilage and menisci in patients with knee osteoarthritis

Wang

Vieira

Rybak

et al. 2013

European Journal of Radiology

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Objective To assess the relationship between knee alignment and subregional T1rho values of the femorotibial cartilage and menisci in patients with mild (Kellgren-Lawrence grade 1) to moderate (KL3) osteoarthritis (OA) at 3T. Materials and methods 26 subjects with a clinical diagnosis of KL1-3 OA were included and subdivided into three subgroups: varus, valgus, and neutral. All subjects were evaluated on a 3T MR scanner. Mann-Whitney and Wilcoxon signed rank tests were performed to determine any statistically significant differences in subregional T1rho values of femorotibial cartilage and menisci among the three subgroups of KL1-3 OA patients. Results Medial femoral anterior cartilage subregion in varus group had significantly higher (p < 0.05) T1rho values than all cartilage subregions in valgus group. Medial tibial central cartilage subregion had significantly higher T1rho values (p < 0.05) than lateral tibial central cartilage subregion in varus group. The posterior horn of the medial meniscus in neutral group had significantly higher T1rho values (p < 0.0029) than all meniscus subregions in valgus group. Conclusion There exists some degree of association between knee alignment and subregional T1rho values of femorotibial cartilage and menisci in patients with clinical OA.

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“…Although others have imaged glenohumeral cartilage using T2 mapping 9 , our study, along with that of La Rocca Vieira et al 7 , is among the first to image glenohumeral cartilage with T1ρ MRI. Furthermore, to our knowledge, our study is the first to use biochemical MRI sequences to evaluate glenohumeral cartilage damage after anterior shoulder dislocation.…”

Section: Discussionmentioning

confidence: 73%

“…While there was little difference in T1ρ values across zones in glenoid cartilage, inferior humeral head cartilage tended to have higher T1ρ values than superior zones in healthy controls. Previously, La Rocca Vieira et al performed T1ρ MRI mapping in four healthy controls to determine baseline T1ρ values for glenoid and humeral head cartilage 7 . They found baseline T1ρ values of 32.4 – 36.9ms for glenoid cartilage and 37.9 – 48.5ms in humeral head cartilage.…”

Section: Discussionmentioning

confidence: 99%

T1ρ Magnetic Resonance Imaging to Assess Cartilage Damage After Primary Shoulder Dislocation

et al. 2016

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Background Patients who suffer anterior shoulder dislocations are at higher risk of developing glenohumeral arthropathy, but little is known about the initial cartilage damage after a primary shoulder dislocation. T1ρ is a magnetic resonance imaging (MRI) technique that allows quantification of cartilage proteoglycan content and can detect physiologic changes in articular cartilage. Purpose To establish baseline T1ρ MRI values for glenoid and humeral head cartilage, determine if T1ρ MRI can detect glenohumeral cartilage damage following traumatic primary shoulder dislocation, and assess for patterns in cartilage damage in anterior shoulder dislocation. Study Design Prospective cohort study Methods Nine male patients (mean age 32.0 years, range 20-59) who sustained first-time anterior shoulder dislocations underwent 3T T1ρ MRI. Five healthy controls (mean age 27.4 years, range 24-30) without prior dislocation or glenohumeral arthritis also underwent 3T T1ρ MRI. The T1ρ relaxation constant was determined for the entire glenoid and humeral head for dislocation patients and healthy controls. The glenoid and humeral head were divided into nine zones, and T1ρ values were determined for each zone in dislocated and control shoulders to identify patterns in cartilage damage in dislocated shoulders. Results Average overall T1ρ values for humeral head cartilage in dislocated shoulders were significantly greater than controls (41.7ms ± 3.9 versus 38.4ms ± 0.6, respectively; p = 0.03). However, average overall T1ρ values for glenoid cartilage were not significantly different in dislocated shoulders compared to controls (44.0ms ± 3.3 versus 44.6ms ± 2.4, respectively; p = 0.40), suggesting worse damage to humeral head cartilage. T1ρ values in the posterior-middle humeral head were higher in dislocation patients compared to controls (41.5ms ± 3.8 versus 38.2ms ± 2.2, respectively; p = 0.021) and trended toward significance in the posterior-superior and middle-superior zones (35.2ms ± 4.9 versus 31.3ms ± 1.0 and 33.7ms ± 5.0 versus 30.5ms ± 1.3, respectively; p = 0.056). These three humeral head zones are where Hill-Sachs lesions predominate. T1ρ values in the anterior-inferior glenoid zone trended toward significance in dislocated patients compared to controls (47.4ms ± 5.0 versus 43.5ms ± 3.5, respectively; p = 0.073). Conclusion Humeral head cartilage sustained greater damage than glenoid cartilage in primary dislocation. T1ρ values were higher in glenohumeral zones associated with Bankart and Hill-Sachs lesions. Widespread initial cartilage damage may predispose patients to glenohumeral arthropathy.

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Three-dimensional spin-lock magnetic resonance imaging of the shoulder joint at 3 T: initial experience

Abstract: We demonstrated that 3D-T(1rho) MRI of the shoulder can be performed on a 3 T clinical scanner within specific absorption rate (SAR) limits, and we present baseline values for healthy patients which may be useful for quantitative comparison with diseased shoulders.

Cited by 6 publications

References 17 publications

T_1ρ MRI of human musculoskeletal system

T_1ρ MRI of human musculoskeletal system

Relationship between knee alignment and T1ρ values of articular cartilage and menisci in patients with knee osteoarthritis

T1ρ Magnetic Resonance Imaging to Assess Cartilage Damage After Primary Shoulder Dislocation

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Three-dimensional spin-lock magnetic resonance imaging of the shoulder joint at 3 T: initial experience

Abstract: We demonstrated that 3D-T(1rho) MRI of the shoulder can be performed on a 3 T clinical scanner within specific absorption rate (SAR) limits, and we present baseline values for healthy patients which may be useful for quantitative comparison with diseased shoulders.

Cited by 6 publications

References 17 publications

T1ρ MRI of human musculoskeletal system

T1ρ MRI of human musculoskeletal system

Relationship between knee alignment and T1ρ values of articular cartilage and menisci in patients with knee osteoarthritis

T1ρ Magnetic Resonance Imaging to Assess Cartilage Damage After Primary Shoulder Dislocation

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T_1ρ MRI of human musculoskeletal system

T_1ρ MRI of human musculoskeletal system