Three-dimensional summation of rectal doses in brachytherapy combined with external beam radiotherapy for prostate cancer

Kikuchi, Kazuko; Nakamura, Ryuji; Tanji, Susumu; Yamaguchi, Satoshi; Kakuhara, H.; Yabuuchi, Tomonori; Inatsu, Wakako; Oikawa, Hirobumi; Ariga, Hiroyoshi

doi:10.1016/j.radonc.2013.03.003

Cited by 14 publications

(17 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have estimated the accumulated rectum dose for combined EBRT/HDR prostate cancer treatment without applying deformable registration [3,7]. However, Kikuchi et al [12] acknowledged that deformable image registration should be part of a more accurate method of accumulating the rectum dose. This current study improved upon these studies by applying deformable image registration and then correlating accumulated rectum dose with various gastrointestinal toxicities.…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, a rigid registration is used to align the reference coordinate systems and then deformable image registration (DIR) is applied to adjust for deformations and shrinkage [9,10]. Additionally, the doses for different fraction schedules should be converted to the equieffective dose given in a reference X Gy per fraction (EQDX α/β Gy) as this adjusts for the biologically nonequivalent fractionation schedules [5,11,12].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prostate external beam radiotherapy combined with high-dose-rate brachytherapy: dose-volume parameters from deformably-registered plans correlate with late gastrointestinal complications

et al. 2016

View full text Add to dashboard Cite

Background: Derivation of dose-volume correlated with toxicity for multi-modal treatments can be difficult due to the perceived need for voxel-by-voxel dose accumulation. With data available for a single-institution cohort with long follow-up, an investigation was undertaken into rectal dose-volume effects for gastrointestinal toxicities after deformably-registering each phase of a combined external beam radiotherapy (EBRT)/high-dose-rate (HDR) brachytherapy prostate treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prostate external beam radiotherapy combined with high-dose-rate brachytherapy: dose-volume parameters from deformably-registered plans correlate with late gastrointestinal complications

et al. 2016

View full text Add to dashboard Cite

show abstract

“…2 The biological non-equivalence of the fractionation schedules can be managed by converting the doses or DVHs to equieffective doses given in 2 Gy fractions. 3,4 Accumulated dose parameters can then be obtained by simply adding the EBRT prescription dose to the HDR-BT DVH parameters or full addition of EBRT and HDR-BT DVH parameters. 2,5 However, crude addition of doses or parameters may not be accurate where there is anatomical deformation and shrinkage.…”

Section: Introductionmentioning

confidence: 99%

“…10 The difference between the methods has been reported for cervical cancer treatments 2,7,[11][12][13][14] and endometrial cancer treatments. 15 However, such studies are lacking in the context of combined EBRT/HDR-BT prostate cancer treatments where rectum dose accumulation 4,9 has not yet progressed to include deformable image registration.…”

Section: Introductionmentioning

confidence: 99%

Accumulation of rectum dose‐volume metrics for prostate external beam radiotherapy combined with brachytherapy: Evaluating deformably registered dose distribution addition using parameter‐based addition

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The requirement for planning systems to allow the user to combine, radiobiologically, the dose distributions from the EBRT and brachytherapy for multimodality treatments is an important area for research and development, which could potentially lead to a better understanding of the clinical effectiveness of a treatment. There have been several publications reporting on the potential clinical usefulness of radiobiological summation of EBRT with brachytherapy, [124][125][126] and this is certainly an area for further research. In IGBT of the cervix, for example, the total dose received by the tumour and OARs from the EBRT and brachytherapy treatments is required so that dose and treatment outcome comparisons can be effectively made between different institutions.…”

Section: 103mentioning

confidence: 99%

Recent developments and best practice in brachytherapy treatment planning

Lee

2014

BJR

View full text Add to dashboard Cite

Brachytherapy has evolved over many decades, but more recently, there have been significant changes in the way that brachytherapy is used for different treatment sites. This has been due to the development of new, technologically advanced computer planning systems and treatment delivery techniques. Modern, three-dimensional (3D) imaging modalities have been incorporated into treatment planning methods, allowing full 3D dose distributions to be computed. Treatment techniques involving online planning have emerged, allowing dose distributions to be calculated and updated in real time based on the actual clinical situation. In the case of early stage breast cancer treatment, for example, electronic brachytherapy treatment techniques are being used in which the radiation dose is delivered during the same procedure as the surgery. There have also been significant advances in treatment applicator design, which allow the use of modern 3D imaging techniques for planning, and manufacturers have begun to implement new dose calculation algorithms that will correct for applicator shielding and tissue inhomogeneities. This article aims to review the recent developments and best practice in brachytherapy techniques and treatments. It will look at how imaging developments have been incorporated into current brachytherapy treatment and how these developments have played an integral role in the modern brachytherapy era. The planning requirements for different treatments sites are reviewed as well as the future developments of brachytherapy in radiobiology and treatment planning dose calculation. CHANGES AND DEVELOPMENTS IN TREATMENT PLANNING TECHNIQUESWithin the past few decades, there have been some major changes to the way brachytherapy treatments are both planned and delivered, and the introduction of modern, three dimensional (3D) imaging techniques have contributed significantly. In the 1930s, before the advent of planning computers, treatment planning was carried out by simply following a set of rules according to a dosimetry system such as the Manchester system. [1][2][3] This system was originally developed for use with radium sources and provided information, in tabular form, for the dose specification and distribution of sources and was used for many years. An increase in radiation safety awareness in the 1970s and 1980s led to a decline in the use of radium in favour of the relatively newer and safer radioisotopes such as caesium-137 and iridium-192. Over the same period, technological advances in afterloading techniques and the wider implementation of computerized planning using planar radiographic imaging were being implemented in an attempt to verify the applicator or catheter positions and calculate patient-specific dose. Alongside these advances, the need to compare patients' treatments with those from other treatment centres was being recognized as an important scientific standardization of treatment. The International Commission on Radiation Units and Measurements (ICRU) reports 38 and 58, 4,5 details t...

show abstract

Three-dimensional summation of rectal doses in brachytherapy combined with external beam radiotherapy for prostate cancer

Cited by 14 publications

References 22 publications

Prostate external beam radiotherapy combined with high-dose-rate brachytherapy: dose-volume parameters from deformably-registered plans correlate with late gastrointestinal complications

Prostate external beam radiotherapy combined with high-dose-rate brachytherapy: dose-volume parameters from deformably-registered plans correlate with late gastrointestinal complications

Accumulation of rectum dose‐volume metrics for prostate external beam radiotherapy combined with brachytherapy: Evaluating deformably registered dose distribution addition using parameter‐based addition

Recent developments and best practice in brachytherapy treatment planning

Contact Info

Product

Resources

About